Methods of diagnosing and treating conduct disorder

ABSTRACT

Methods for diagnosing and treating conduct disorder are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims priority to the following four United States Provisional patent applications, each filed on Sep. 8, 2015: Ser. Nos. 62/215,628; 62/215,633; 62/215,636; and 62/215,673, each of which is incorporated herein by reference in its entirety.

FIELD OF THE INVENTION

This application relates to the treatment of conduct disorder with nonselective activators of metabotropic glutamate receptors (mGluRs) and of diagnosis and treatment of conduct disorder in subjects having genetic alterations, such as copy number variations (CNVs), in one or more mGluR network genes.

BACKGROUND AND SUMMARY

Conduct disorder encompasses a group of behavioral and emotional problems in children that lead them to have great difficulty in following rules and behaving in a socially acceptable manner. Conduct disorder is characterized by repetitive patterns of behaviors that violate the rights of others or that break societal rules. Children and adolescents with conduct disorder display behaviors such as aggression to people and animals; destruction of property; deceitfulness, lying or stealing; and/or seriously violating age-appropriate rules. Factors that may contribute to the development of conduct disorder include brain damage, child abuse, genetic vulnerability, school failure, and traumatic life experiences (see American Academy of Child & Adolescent Psychiatry: Conduct Disorders (2013) and Ercan E S, et al. Child Adolesc Psychiatry Ment Health. 5(1):10 (2011)).

The estimated lifetime prevalence of conduct disorder in the US is 9.5%, with more males than females affected (see Nock M K, et al. Psychol. Med. 36(5):699-710 (2006)). Symptoms of conduct disorder, such as aggression and antisocial behaviors, are the primary presenting problems that lead to psychiatric referral in children and adolescents in the US. Many children and adolescents with conduct disorder also have coexisting conditions such as mood disorders, anxiety, post-traumatic stress disorder (PTSD), substance abuse, attention deficit hyperactivity disorder (ADHD), or learning disorders. Children and adolescents with conduct disorder who do not receive treatment are likely to exhibit antisocial behavior in adulthood and to have continuing difficulty as adults with relationships and in the workplace. Conduct disorder during childhood or adolescence is associated with increased risk of associated mental disorders, legal troubles, and premature mortality.

Currently, conduct disorder is diagnosed using one or more rating scales, such as the Conduct Disorder Rating Scale (CDRS) as described in Waschbusch DA Assessment 14(1):65-74(2007)), which has been validated in patients from 5 years to 12 years of age and has been shown to be appropriate for clinical studies of conduct disorder. Alternatively, the Aberrant Behavior Checklist (ABC) (see Sansone S M J Autism Dev Disord 42(7): 1377-1392 (2012)) may be used to assess conduct disorder, as the ABC has been widely used, has shown sensitivity in clinical trials of agents to treat problematic behaviors, and can be used in patients with intellectual disability.

Behavior and psychotherapy are usually necessary to help patients with conduct disorder to express and control anger (see American Academy of Child & Adolescent Psychiatry: Conduct Disorders (2013)). Medication may also help patients with conduct disorder control symptoms of depression, impulse control, and ADHD. In both children and adolescents, antipsychotics may be used to attempt to control aggressive symptoms of conduct disorder, although their efficacy is unproven (Toteja N, Int J Neuropychopharmacol 17(7):1095-105 (2014)). The use of antipsychotics in children and adolescents with conduct disorder can reduce aggression; however, their use also raises concerns of side effects such as changes in prolactin levels (see James A C Adv Psychiatr Treat 16:63-75 (2010) and Ercan 2011). Currently, there are limited pharmacotherapy options for children and adolescents with conduct disorder, and these treatments are only considered when behavioral treatments and family interventions do not provide benefit.

SUMMARY

The inventors have studied the genotypes of over 800 patients diagnosed with conduct disorder and have found that these patients possess genetic alterations in one or more metabotropic glutamate receptor (mGluR) network genes at a significantly higher frequency than in healthy controls. The frequency of genetic alterations in mGluR network genes was also substantially higher in this conduct disorder population than in control populations that do not have other neuropsychological disorders.

Thus, provided herein are methods of treating conduct disorder in a subject, comprising administering an effective amount of a nonselective activator of metabotropic glutamate receptors (mGluRs) to a subject, thereby treating conduct disorder. In some embodiments the subject has at least one genetic alteration in a mGluR network gene, such as a copy number variation (CNV) or single nucleotide variation (SNV). Also provided herein are methods of treating conduct disorder, comprising administering an effective amount of a nonselective activator of metabotropic glutamate receptors (mGluRs) to a subject that has at least one genetic alteration in an mGluR network gene, such as a CNV, thereby treating conduct disorder. In some embodiments, where the subject has a CNV in a mGluR network gene, the CNV is a duplication or deletion.

Also provided are methods of treating conduct disorder in a subject comprising obtaining results from a genetic screen that determines whether a subject has a genetic alteration in an mGluR network gene, and, if the results show that the subject has at least one genetic alteration in an mGluR network gene, treating the subject by administering an effective amount of a nonselective activator of mGluRs.

In some embodiments, a method for treating conduct disorder is provided comprising administering an effective amount of a nonselective activator of metabotropic glutamate receptors (mGluRs) to a subject, wherein the subject has at least one symptom of conduct disorder, thereby treating conduct disorder. In some embodiments, a method for treating conduct disorder is provided comprising administering an effective amount of a nonselective activator of metabotropic glutamate receptors (mGluRs) to a subject, wherein the subject has at least one symptom of conduct disorder and at least one genetic alteration in an mGluR network gene, thereby treating conduct disorder. The skilled artisan can identify symptoms of conduct disorder, for example, by referring to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) (2013). Symptoms include persistent, repetitive patterns of behavior that violate either the basic rights of others or major societal norms.

In some embodiments of the above methods, the nonselective activator of mGluRs is fasoracetam, such as fasoracetam monohydrate (NS-105 or NFC-1). In some embodiments the fasoracetam is administered at a dose of 50 mg, 100 mg, 150 mg, 200 mg, 250 mg, 300 mg, 350 mg, or 400 mg, wherein the dose is administered once, twice, or three times daily. In some embodiments, fasoracetam is administered at a dose of 50-400 mg, 100-400 mg, or 200-400 mg, and administered once, twice, or three times daily. In some embodiments, the fasoracetam is administered at a dose of 200-400 mg, such as 200 mg, 300 mg, or 400 mg, and administered twice daily.

In some embodiments the method comprises considering results of a screen to determine whether the subject has a genetic alteration such as a CNV in an mGluR network gene. In some embodiments of the above methods, the subject has a CNV in at least 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mGluR network genes. In some embodiments a CNV in an mGluR network gene is determined by obtaining a nucleic acid-comprising sample from the subject and subjecting the sample to a screen that assesses CNVs in at least 5, 6, 7, 8, 9, 10, 15, 20, 30, 40, 50, 60, 70, or all of Tier 1 mGluR network genes. In some embodiments a CNV in a mGluR network gene is determined by obtaining a nucleic acid-comprising sample from the subject and subjecting the sample to a screen that assesses CNVs in at least 50, at least 100, at least 150, at least 175, or all of Tier 2 mGluR network genes. In some embodiments a CNV in a mGluR network gene is determined by obtaining a nucleic acid sample from the subject and subjecting the sample to a screen that assesses CNVs in at least 50, at least 100, at least 200, at least 300, at least 400, at least 500, or all of Tier 3 mGluR network genes. In some embodiments the screen does not assess CNVs in one or more of GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, or GRM8. In certain embodiments the subject does not have a CNV in one or more of GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, or GRM8.

In some embodiments of the above methods, the subject has antisocial personality disorder. In some embodiments the subject is a pediatric or adolescent subject, such as between the ages of 5 and 17, 5 and 8, 8 and 17, 8 and 12, 12 and 18, 13 and 18, or 12 and 17. In other embodiments the subject is an adult.

In some embodiments of the above methods, the nonselective activator of mGluRs is administered in combination with another pharmaceutical, such as an antipsychotic agent, or non-pharmaceutical therapy. The non-pharmaceutical therapy may comprise brain stimulation, such as vagus nerve stimulation, repetitive transcranial magnetic stimulation, magnetic seizure therapy, or deep brain stimulation.

In some embodiments, symptoms of inattentiveness, hyperactivity, and/or impulsiveness are reduced in the subject. In some embodiments, symptoms of aggressiveness or antisocial behavior are reduced. In some embodiments, the methods reduce other behavioral symptoms such as mood disorders or sleep disorders. In some embodiments, the methods also comprise assessing symptoms such as aggressiveness or antisocial behavior as well as inattentiveness, hyperactivity, and/or impulsiveness during or after administration, for example, to determine if one or more of those symptoms have been reduced in the subject. In some methods, such assessment may be performed based on the Conner's comprehensive behavior rating scale. In some embodiments, the methods further comprise obtaining a clinical global impression of severity or improvement for the subject during or after administration. In some embodiments, the methods may improve clinical global improvement scores in the subject. Such symptoms may be reduced, for example, after 1 week of treatment with the activator, such as after 2 weeks, 3 weeks, or 4 weeks of treatment.

Also provided herein are methods for diagnosing conduct disorder in a subject comprising isolating a nucleic-acid comprising sample from a subject, analyzing the sample for the presence or absence of a genetic alteration in at least one mGluR network genes, and diagnosing conduct disorder if the subject has at least one genetic alteration in a mGluR network gene. Also provided are methods for diagnosing conduct disorder in a subject comprising isolating a nucleic-acid comprising sample from a subject, isolating nucleic acid from the sample, analyzing the nucleic acid for the presence or absence of a genetic alteration in at least one mGluR network genes, and diagnosing conduct disorder if the subject has at least one genetic alteration in a mGluR network gene. Provided as well are methods for identifying a subject as having conduct disorder comprising obtaining a sample from a patient, optionally isolating nucleic acid from the sample, optionally amplifying the nucleic acid, and analyzing the nucleic acid in the sample for the presence or absence of a genetic alteration, such as a CNV, in at least one mGluR network gene, wherein the subject is identified as having conduct disorder if at least one genetic alteration, such as a CNV, in an mGluR network gene is detected. Also provided are methods for diagnosing conduct disorder in a subject, comprising analyzing genetic information about one or more mGluR network genes, comparing the subject's information to a control subject that does not have conduct disorder, and diagnosing conduct disorder if the genetic information suggests that the subject has at least one genetic alteration in a mGluR network gene.

Provided herein also are methods of confirming a diagnosis of conduct disorder in a subject comprising: obtaining a nucleic acid-comprising sample from a subject diagnosed with conduct disorder by a method that does not comprise detecting or analyzing genetic alterations in mGluR network genes; optionally amplifying the nucleic acid in the sample; and determining whether the subject has at least one genetic alteration, such as a CNV, in an mGluR network gene, and confirming a diagnosis of conduct disorder if the subject has at least one genetic alteration in an mGluR network gene.

In any of the above methods, the analysis for the presence or absence of at least one genetic alteration in an mGluR network gene may comprise the use of microarrays, whole genome sequencing, exome sequencing, targeted sequencing, FISH, comparative genomic hybridization, genome mapping, or other methods using next-generation sequencing, Sanger sequencing, PCR, or TaqMan technologies.

In some embodiments, the subject has CNVs in one, two, or more mGluR network genes. In some embodiments, the methods comprise detecting CNVs in mGluR network genes by subjecting the sample to a screen that assesses CNVs in at least 2, 3, 4, 5, 6, 7, 8, 9, or 10 mGluR network genes. In some embodiments, CNVs in mGluR network genes are determined by subjecting the sample to a screen that assesses CNVs in at least 5, 6, 7, 8, 9, 10, 15, 20, 30, 40, 50, 60, 70, or all of Tier 1 mGluR network genes. In some embodiments, CNVs in mGluR network genes are determined by subjecting the sample to a screen that assesses CNVs in at least 50, at least 100, at least 150, at least 175, or all of Tier 2 mGluR network genes. In some embodiments, CNVs in mGluR network genes are determined by subjecting the sample to a screen that assesses CNVs in at least 50, at least 100, at least 200, at least 300, at least 400, at least 500, or all of Tier 3 mGluR network genes.

In some embodiments of the above methods, the subject has antisocial personality disorder. In some embodiments, the subject is a pediatric or adolescent subject, such as a subject between the ages of 5 and 17, 5 and 8, 8 and 17, 8 and 12, 12 and 18, 13 and 18, or 12 and 17. In other embodiments, the subject is an adult subject.

In some embodiments, the screening method for determining the presence or absence of at least one mGluR network gene genetic alteration comprises the use of microarrays, whole genome sequencing, exome sequencing, targeted sequencing, FISH, comparative genomic hybridization, genome mapping, or other methods using next-generation sequencing, Sanger sequencing, PCR, or TaqMan technologies.

In some embodiments, the subject is not assessed for genetic alterations or CNVs in one or more of GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, and GRM8. In some embodiments, the subject does not have CNVs in one or more of GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, and GRM8. In some embodiments, the subject does not have CNVs in any of GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, and GRM8.

In any of the methods and embodiments described in the preceding paragraphs of this Summary, the subject may have conduct disorder as well as one or more comorbid conditions such as attention-deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), autism, a mood disorder, Tourette syndrome, anxiety disorder, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression. In other cases, the subject does not have one or more of ADHD, ODD, autism, a mood disorder, Tourette syndrome, anxiety disorder, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression. In yet other cases, the subject does not have any of ADHD, ODD, autism, a mood disorder, Tourette syndrome, anxiety disorder, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression. In some embodiments, the subject does not have any of OCD, phobia, or depression.

In some embodiments, the subject has co-morbid symptoms of anxiety and in some cases, the method reduces anxiety symptoms. In some embodiments, the subject has OCD and in some cases, the method reduces OCD symptoms. In some cases, the subject has co-morbid symptoms of dermatillomania, such as excessive skin picking, and the method reduces those symptoms. In some embodiments, the subject has one or more co-morbid developmental disorders, and in some cases, the method reduces the severity of symptoms related to the developmental disorders.

In any of the methods herein, the subject may have ADHD as well as conduct disorder. In any of the methods herein, the subject may have one or more of the following phenotypic changes after at least 1 week, such as at least 2 weeks, at least 3 weeks, or at least 4 weeks of treatment with the activator: (a) the subject has difficulty controlling anger and the anger control symptoms are improved; (b) the subject has disruptive behaviors and the disruptive behaviors are reduced; (c) the subject's CGI-I is reduced by at least 1 or by at least 2; the subject's CGI-I score after one, two, three, or four weeks of treatment is 1 or 2; (d) the subject's CGI-S score after one, two, three, or four weeks of treatment is 1; the subject's ADHD Rating Scale score is reduced by at least 25%, such as at least 30%, at least 35%, or at least 40%; (e) the subject has symptoms of inattentiveness and the inattentiveness symptoms are reduced; the subject has symptoms of hyperactivity and the hyperactivity symptoms are reduced; (f) the subject has symptoms of impulsiveness and the impulsiveness symptoms are reduced; (g) the subject has symptoms of ODD such as anger and irritability, argumentation and defiance, and/or vindictiveness and the ODD symptoms are reduced; (h) the subject has symptoms of anxiety and the anxiety symptoms are reduced; (i) the subject has symptoms of Tourette's syndrome, and the Tourette's syndrome symptoms are reduced; (j) the subject has symptoms of autism, and the autism symptoms are reduced; and (k) the subject has symptoms of movement disorder and the movement disorder symptoms are reduced.

In one embodiment, a method for diagnosing an mGluR-associated disorder is provided, wherein a subject is diagnosed with an mGluR-associated disorder if at least one genetic alteration in an mGluR network gene is detected.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows the number of samples from patients with conduct disorder, depression, obsessive-compulsive disorder (OCD), and phobias included in a genotyping study designed to assess genetic alterations in mGluR network genes. Only those patient samples that were fully genotyped are included in the data analysis.

FIGS. 2-1 to 2-4 show the mGluR network genes included in the Tier 1 gene set. These genes have 2 degrees of protein-protein interaction with mGluR genes (GRM1-8) based on the Cytoscape Human Interactome, which is software for integrating biomolecular interaction networks with high-throughput data (as described in Shannon P (2003) Genome Research 13:2498-2504). The Tier 1 gene set includes 76 genes. The exact location for each gene in Tier 1 is listed in both the Human Genome version 18 (hg18) and Human Genome version 19 (hg19). In addition, the exact gene location plus 500 kilobase (i.e., the range from 500 kilobase before and 500 kilobase after the gene of interest) is listed for hg19. The start single nucleotide polymorphism (StartSNP) (i.e., the SNP located 500 kilobases before the gene of interest) and the EndSNP (i.e., the SNP located 500 kilobases after the gene of interest) are also listed. Genes of the mGluRs themselves are noted as “GRM.” The expanded regions (i.e., 500 kg up and down stream) frequently harbor regulatory elements and if impacted by a CNV, can have the same impact on the gene expression and function as a CNV residing in the gene sequence itself.

FIGS. 3-1 to 3-10 show the mGluR network genes included in the Tier 2 gene set. These genes have 2 degrees of protein-protein interaction with mGluR genes (GRM1-8) based on the Cytoscape Human Interactome but exclude genes from Tier 1. The Tier 2 gene set includes 197 genes. The exact location for each gene in Tier 2 is listed in both the Human Genome version 18 (hg18) and Human Genome version 19 (hg19). In addition, the exact gene location plus 500 kilobase (i.e., the range from 500 kilobase before and 500 kilobase after the gene of interest) is listed for hg19. The start single nucleotide polymorphism (StartSNP) (i.e., the SNP located 500 kilobases before the gene of interest) and the EndSNP (i.e., the SNP located 500 kilobases after the gene of interest) in hg19 are also listed.

FIGS. 4-1 to 4-29 show genes within the Tier 3 gene set. Genes with reciprocal gene querying with 2 degrees of protein-protein interaction with mGluR genes based on Cytoscape Human Interactome are included. Genes contained within Tiers 1 and 2 are excluded from Tier 3. The Tier 3 gene set includes 599 genes. The exact location for each gene in Tier 3 is listed in both the Human Genome version 18 (hg18) and Human Genome version 19 (hg19). In addition, the exact gene location plus 500 kilobase (i.e., the range from 500 kilobase before and 500 kilobase after the gene of interest) is listed for hg19. The StartSNP (i.e., the SNP located 500 kilobases before the gene of interest) and the EndSNP (i.e., the SNP located 500 kilobases after the gene of interest) in hg19 are also listed.

FIG. 5 shows the number of copy number variation (CNV) calls containing a Tier gene (mGluR network gene) within the samples from the 861 conduct disorder patients who were fully genotyped; the 95 depression patients who were fully genotyped; the 150 OCD patients that were fully genotyped; and the 55 phobia patients that were fully genotyped. Note that some patients had more than one CNV call that contained an mGluR network gene.

FIG. 6 shows the percentage of fully-genotyped patients with conduct disorder, depression, OCD, or phobia who had a CNV within Tier 1, Tiers 1+2, or Tiers 1+2+3 mGluR network gene sets.

DESCRIPTION OF PARTICULAR EMBODIMENTS Definitions

In addition to definitions included in this sub-section, further definitions of terms are interspersed throughout the text.

In this invention, “a” or “an” means “at least one” or “one or more,” etc., unless clearly indicated otherwise by context. The term “or” means “and/or” unless stated otherwise. In the case of a multiple-dependent claim, however, use of the term “or” refers back to more than one preceding claim in the alternative only.

A “mGluR” or metabotropic glutamate receptor refers to one of eight glutamate receptors expressed in neural tissue named mGluR1, mGluR2, mGluR3, mGluR4, mGluR5, mGluR6, mGluR7, and mGluR8. Their genes are abbreviated GRM1 to GRM8. The mGluR proteins are G-protein-coupled receptors. They are typically placed into three sub-groups, Group I receptors including mGluR1 and mGluR5 are classed as slow excitatory receptors. Group II includes mGluR2 and mGluR3. Group III includes mGluR4, mGluR6, mGluR7, and mGluR8. Groups II and III are classed as slow inhibitory receptors. The mGluRs are distinguished from the ionotropic GluRs or iGluRs, which are ion channel-associated glutamate receptors and are classed as fast excitatory receptors.

A “mGluR network gene,” for purposes of this invention, comprises not only the mGluR genes GRM1, GRM7, and GRM8, but also each of the other genes listed herein in FIGS. 2-4 as well as the regions of DNA that regulate the genes listed in FIGS. 2-4. In addition, “mGluR network proteins” are the proteins encoded by the mGluR network genes.

The mGluR network genes are grouped into three subsets: Tier 1, Tier 2, and Tier 3. (See FIGS. 2-4.) Tier 1 mGluR network genes, shown in FIG. 2, comprise 76 genes, including some GRM genes themselves as well as a number of other genes. The Tier 2 mGluR network genes, shown in FIG. 3, comprise 197 genes, and exclude the Tier 1 genes.

Tiers 1 and 2 together are included in the “primary mGluR network.” The “primary network” of mGluR genes also includes the genes 4-Sep, LOC642393, and LOC653098, for a total of 276 genes. There are presently technical difficulties in assessing the 4-Sep, LOC642393, and LOC653098 genes. Thus, they are not included in the genes of Tiers 1 and 2, although they are included in the primary network of genes of the present invention. The genes of Tier 1 and Tier 2 differ in that alterations in Tier 1 genes had been documented in previous genotyping studies of subjects suffering from mental disorders.

Tier 3 mGluR network genes, shown in FIG. 4, comprise 599 genes that are in the distal part of the mGluR network based on the merged human interactome provided by the Cytoscape Software (Shannon P et al. (2003) Genome Research 13:2498-2504), and exclude the Tier 1 and Tier 2 genes. The Tier 3 genes are thus part of the “distal mGluR network.” In addition to the Tier 3 genes, the genes LOC285147, LOC147004, and LOC93444 are included in the “distal mGluR network,” although they were not assessed in the present study and are not included in Tier 3 due to technical difficulties in assessing genetic alterations in these genes.

A “genetic alteration” as used herein means any alteration in the DNA of a gene, or in the DNA regulating a gene, for example, that may result in a gene product that is functionally changed as compared to a gene product produced from a non-altered DNA. A functional change may be differing expression levels (up-regulation or down-regulation) or loss or change in one or more biological activities, for example. A genetic alteration includes without limitation, copy number variations (CNVs), single nucleotide variations (SNVs) (also called single nucleotide polymorphisms (SNPs), frame shift mutations, or any other base pair substitutions, insertions, and deletions or duplications.

A “copy number variation” or “CNV” is a duplication or deletion of a DNA segment encompassing a gene, genes, segment of a gene, or DNA region regulating a gene, as compared to a reference genome. In some embodiments, a CNV is determined based on variation from a normal diploid state. In some embodiments, a CNV represents a copy number change involving a DNA fragment that is 1 kilobase (kb) or larger. CNVs described herein do not include those variants that arise from the insertion/deletion of transposable elements (e.g., 6-kb KpnI repeats). The term CNV therefore encompasses terms such as large-scale copy number variants (LCVs; Iafrate et al. 2004), copy number polymorphisms (CNPs; Sebat et al. 2004), and intermediate-sized variants (ISVs; Tu

un et al. 2005), but not retrotransposon insertions.

A “CNV deletion” or “deletion CNV” or similar terms refer to a CNV in which a gene, DNA segment regulating a gene, or gene segment is deleted. A “CNV duplication” or “duplication CNV” or similar terms refer to a CNV in which a gene, DNA segment regulating a gene, or gene segment is present in at least two, and possibly more than two, copies in comparison with the single copy found in a normal reference genome.

A “sample” refers to a sample from a subject that may be tested, for example, for presence of a CNV in one or more mGluR network proteins, as described herein. The sample may comprise cells, and it may comprise body fluids, such as blood, serum, plasma, cerebral spinal fluid, urine, saliva, tears, pleural fluid, and the like.

“Conduct disorder” is defined in the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) (2013) as a persistent, repetitive pattern of behavior that violates either the basic rights of others or major societal norms. Typically, conduct disorder is diagnosed in patients prior to adulthood (i.e., younger than 18 years of age). A diagnosis of conduct disorder may be based on significant impairment in social, academic, or occupational functioning. Currently, conduct disorder is diagnosed using one or more rating scales, such as, the CDRS (Waschbusch 2007) or the ABC (Sansone 2012). Patients with conduct disorder may also have inattention, hyperactivity, anxiety, mood, and sleep disturbances.

“Antisocial personality disorder” is defined by the DSM-5 (2013) as a pervasive pattern of disregard for and violation of the rights of others in individuals who are at least 18 years of age and who exhibited onset of symptoms before 15 years of age. Therefore, antisocial personality disorder may be later diagnosed in adulthood in an individual who displayed symptoms consistent with those of conduct disorder during childhood or adolescence. A patient with antisocial personality disorder may have been previously diagnosed with conduct disorder during childhood or adolescence. In this application, a patient with conduct disorder includes subject who are older than 18 years of age and who were previously diagnosed with conduct disorder. In this application, a patient with conduct disorder also includes patients older than 18 years of age who were not diagnosed with conduct disorder as a child or adolescent, but who displayed symptoms consistent with conduct disorder as a child or adolescent. Therefore, antisocial personality disorder is included in the definition of conduct disorder within this application.

The terms “subject” and “patient” are used interchangeably to refer to a human. The terms “pediatric subject” or “pediatric patient” are used interchangeably to refer to a human less than 18 years of age. An “adult patient” refers to a human 18 years of age or older. An “adolescent patient” or “adolescent subject” is a subject typically about 12 to 18, such as 12 to 17 or 13 to 18, years old.

Methods of Diagnosing Conduct Disorder

In some embodiments, the invention comprises a method of diagnosing conduct disorder in a subject comprising analyzing the genetic information of the subject to determine whether the subject has a genetic variation in at least one mGluR network gene, and diagnosing the subject as having conduct disorder if a genetic variation is found. In some embodiments, the subject has conduct disorder but does not have any of ADHD, oppositional defiant disorder (ODD), autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression. In some embodiments, the subject has conduct disorder and also one or more of ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, and depression.

“Developmental disorders” herein include, for example, those classified under the International Classification of Diseases 9th Ed. (World Health Organization) under codes 299.80, 299.90, 315.2, 315.39, 315.4, 315.5, 315.8, and 315.9, and may affect behaviors such as learning, coordination, and speech. “Dermatillomania” is also called skin picking disorder or excoriation, and is a disorder involving excessive picking at one's own skin to the extent of causing damage, and includes picking at normal skin as well as at real or imagined skin defects such as moles, freckles, or acne.

In other embodiments, the invention encompasses confirming a diagnosis of conduct disorder in a subject. As used herein, “confirming a diagnosis of conduct disorder” means diagnosing a subject who has already been diagnosed with conduct disorder. In this one embodiment, the method of confirming a diagnosis of conduct disorder comprises analyzing the genetic information of a subject that has been diagnosed as having conduct disorder by a method that does not comprise analyzing mGluR network genes, to determine whether the subject has a genetic variation in at least one mGluR network gene, and confirming the diagnosis of conduct disorder if a genetic variation in at least one mGluR network gene is found. In some embodiments, the subject has conduct disorder but does not have any of ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression. In some embodiments, the subject has conduct disorder and also one or more of ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, and depression.

In other embodiments, the invention comprises confirming a diagnosis of conduct disorder in a subject who does not have ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression, comprising analyzing the genetic information of a subject that has been diagnosed as having conduct disorder by a method that does not comprise analyzing mGluR network genes, to determine whether the subject has a genetic variation in at least one mGluR network gene, and confirming the diagnosis of conduct disorder if a genetic variation in at least one mGluR network gene is found.

In one embodiment, conduct disorder is diagnosed and/or confirmed if at least one CNV, SNV, frameshift mutation, or any other base pair substitution, insertion, deletion or duplication in an mGluR network gene is detected. In other embodiments, conduct disorder is diagnosed and/or confirmed if at least one CNV, SNV, frameshift mutation, or any other base pair substitution, insertion, deletion or duplication in a Tier 1 mGluR network gene is detected. In another embodiment, conduct disorder is diagnosed and/or confirmed if at least one CNV, SNV, frameshift mutation, or any other base pair substitution, insertion, duplication or deletion in a Tier 2 mGluR network gene is detected. In still other embodiments, conduct disorder is diagnosed and/or confirmed if at least one CNV, SNV, frameshift mutation, or any other base pair substitution, insertion, duplication or deletion in a Tier 3 mGluR network gene is detected.

A diagnosis or confirmation of diagnosis of conduct disorder may be based or confirmed on finding a genetic alteration in a Tier 1, Tier 2, and/or Tier 3 mGluR network gene. The genetic alteration may be a CNV. The CNV may be a duplication or deletion of a region of DNA that contains some or all of the DNA encoding and controlling/regulating an mGluR network gene. In another embodiment, the diagnosis or confirmation of diagnosis of conduct disorder is made in a patient who does not have ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression. In some embodiments, the diagnosis or confirmation of diagnosis of conduct disorder is made in a patient who has ADHD, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, and/or depression.

In some embodiments, the diagnosis or confirmation of diagnosis of conduct disorder is based on a finding that the copy number of an mGluR network gene deviates from the normal diploid state. In some embodiments, the diagnosis or confirmation of diagnosis of conduct disorder is based on a copy number of zero or one, which indicates a CNV deletion. In some embodiments, the diagnosis or confirmation of diagnosis of conduct disorder is based on a copy number of three or greater, which indicates a CNV duplication. In some embodiments, the diagnosis or confirmation of diagnosis of an anxiety disorder is made in a patient who does not have ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression by the presence of a copy number of zero or one, or by a copy number of three or greater, or by any deviation from the diploid state.

In other embodiments, the diagnosis or confirmation of diagnosis of conduct disorder is made in a patient who has ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression by the presence of a copy number of zero or one, by a copy number of three or greater, or by any deviation from the diploid state. In another embodiment, the diagnosis or confirmation of diagnosis of conduct disorder is made in a patient who does not have ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression by the presence of a copy number of zero or one, by a copy number of three or greater, or by any deviation from the diploid state.

In some embodiments, a more severe form of conduct disorder is diagnosed if at least two CNVs in mGluR network genes are detected. In one embodiment, a more severe form of conduct disorder in a patient who does not have ADHD, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression is diagnosed if at least two CNVs in mGluR network genes are detected.

In one embodiment, a method of diagnosing and/or confirming conduct disorder comprises obtaining a nucleic acid-containing sample from a subject;

-   -   optionally amplifying the nucleic acid;     -   optionally labeling the nucleic acid sample;     -   applying the nucleic acid to a solid support that comprises one         or more nucleic acids of mGluR network genes, wherein the         nucleic acids optionally comprise SNPs of mGluR network genes;     -   removing any unbound nucleic acid sample; and     -   detecting any nucleic acid that has bound to the nucleic acid on         the solid support, wherein the subject is diagnosed or confirmed         as having conduct disorder if bound nucleic acids are detected.         In one embodiment the method further comprises comparing any         bound nucleic acids to a standard or control and diagnosing or         confirming conduct disorder if the analysis finds that the test         sample is different from the control or standard. In another         embodiment of this method, the patient with conduct disorder         does not have any of ADHD, ODD, autism, a mood disorder, anxiety         disorder, Tourette's syndrome, phobia, obsessive compulsive         disorder (OCD), difficulty controlling anger, disruptive         behavior symptoms, dermatillomania, a movement disorder, a         developmental disorder, or depression. In some embodiments, the         patient with conduct disorder has one or more of ADHD, ODD,         autism, a mood disorder, anxiety disorder, Tourette's syndrome,         phobia, obsessive compulsive disorder (OCD), difficulty         controlling anger, disruptive behavior symptoms,         dermatillomania, a movement disorder, a developmental disorder,         or depression.

In each diagnostic, confirming, and treatment method of the invention, the subject may have a conduct disorder but not have ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression. In other diagnostic, confirming, and treatment methods of the invention, the subject has conduct disorder and one or more additional disorders such as ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression.

Methods of Treating Conduct Disorder

Encompassed herein are methods of treating conduct disorder in a subject, comprising administering an effective amount of a nonselective mGluR activator. The term “treatment,” as used herein, includes any administration or application of a therapeutic for a disease or disorder in a subject, and includes inhibiting the disease, arresting its development, relieving the symptoms of the disease, or preventing occurrence or reoccurrence of the disease or symptoms of the disease. In some embodiments, conduct disorder is said to be treated if there is an improvement in antisocial behavior, a reduction in episodes of violation of others rights, or a reduction in conflicts with the law.

The mGluR proteins are typically placed into three sub-groups, group I receptors including mGluR1 and mGluR5 are classed as slow excitatory receptors. Group II includes mGluR2 and mGluR3. Group III includes mGluR4, mGluR6, mGluR7, and mGluR8. Groups II and III are classed as slow inhibitory receptors. The mGluRs are distinguished from the ionotropic GluRs or iGluRs, which are ion channel-associated glutamate receptors and are classed as fast excitatory receptors.

A “nonselective activator of mGluRs” refers to a molecule that activates mGluRs from more than one of the group I, II, and III categories. Thus, a nonselective activator of mGluRs may provide for a general stimulation of the mGluR networks. This is in contrast to specific mGluR activators that may only significantly activate a single mGluR, such as mGluR5, for example. Nonselective mGluR activators include, for example, nonselective mGluR agonists.

In some embodiments, the nonselective mGluR activator is fasoracetam. Fasoracetam is a nootropic (i.e., cognitive-enhancing) drug that can stimulate both group I and group II/III mGluRs in in vitro studies. (See Hirouchi M, et al. (2000) European Journal of Pharmacology 387:9-17.) Fasoracetam may stimulate adenylate cyclase activity through activation of group I mGluRs, while it may also inhibit adenylate cyclase activity by stimulating group II and III mGluRs. (Oka M, et at (1997) Brain Research 754:121-130.) Fasoracetam has been observed to be highly bioavailable (79%-97%) with a half-life of 5-6.5 hours in prior human studies (see Malykh A G, et al. (2010) Drugs 70(3):287-312). Fasoracetam is a member of the racetam family of chemicals that share a five-carbon oxopyrrolidone ring. The structure of fasoracetam is:

The term “fasoracetam” as used herein encompasses pharmaceutically acceptable hydrates and any solid state, amorphous, or crystalline forms of the fasoracetam molecule. For example, the term fasoracetam herein includes forms such as NFC-1: fasoracetam monohydrate. In addition to NFC-1, fasoracetam is also known as C-NS-105, NS105, and LAM-105.

NFC-1 has been previously studied in Phase I-III clinical trials in dementia-related cognitive impairment but did not show sufficient efficacy in dementia in Phase III trials. These trials demonstrated that NFC-1 was generally safe and well tolerated for those indications. Phase III data indicated that NFC-1 showed beneficial effects on psychiatric symptoms in cerebral infarct patients and adult dementia patients with cerebrovascular diseases.

In each of the method of treatment embodiments, a metabotropic glutamate receptor positive allosteric modulator, a metabotropic glutamate receptor negative allosteric modulator, or a tachykinin-3/neurokinin-3 receptor (TACR-3/NK3R) antagonist may be administered alone or in combination with a nonselective activator of mGluRs, for example, to subjects having an alteration in a mGluR network gene. In some embodiments, the treatment agent comprises ADX63365, ADX50938, ADX71149, AMN082, a 1-(hetero)aryl-3-amino-pyrrolidine derivative, LY341495, ADX48621, GSK1144814, or SB223412.

Also encompassed herein are methods of treating conduct disorder, comprising administering a nonselective mGluR activator such as fasoracetam to a subject that has a genetic alteration in at least one mGluR network gene. In some embodiments, this subject has anxiety disorder but does not have ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression, while in other embodiments, the subject has conduct disorder as well as at least one of ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression.

In some embodiments, the treatment methods comprise identifying or diagnosing a subject as having a genetic alteration in at least one mGluR network gene, and administering a nonselective mGluR activator such as fasoracetam to the identified or diagnosed subject. In some of the embodiments, the subject has conduct disorder, but does not have ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression. In other embodiments, the subject has conduct disorder, as well as one or more neuropsychological disorders such as ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, and depression.

In each method of treating embodiment of the invention, nonselective mGluR activator may improve symptoms of inattention, hyperactivity, anxiety, mood, and sleep disturbances that may be seen in patients with conduct disorder. It may also reduce symptoms of aggression and/or antisocial behavior.

Some embodiments include a method of treating conduct disorder comprising identifying or diagnosing a subject as having a genetic alteration in at least one mGluR network gene, and administering an effective amount of a nonselective activator of mGluRs such as fasoracetam to the identified or diagnosed subject. In some of the embodiments, the subject has conduct disorder, but does not have any of ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression. In other embodiments, the subject has conduct disorder, as well as one or more neuropsychological disorders such as ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, and depression.

In each method of treating embodiment of the invention, the subject may have conduct disorder, but not one or more neuropsychological disorders such as ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, and depression.

In one embodiment, an effective amount of a nonselective activator of mGluRs such as fasoracetam is administered to a subject that has conduct disorder and has been confirmed as having at least one genetic alteration in an mGluR network gene. The genetic alteration may be in a Tier 1 mGluR network gene. The genetic alteration may be in a Tier 2 mGluR network gene. The genetic alteration may be in a Tier 3 mGluR network gene. The genetic alteration may be more than one genetic alteration, and the more than one alteration may be in one of Tiers 1, 2, or 3, or in any combination of Tiers.

Some embodiments include a method of treating conduct disorder comprising obtaining genetic information about a subject's mGluR network genes, and administering an effective amount of a nonselective activator of mGluRs such as fasoracetam if the subject has at least one genetic alteration, such as a CNV, in an mGluR network gene. Other embodiments encompass a method of treating conduct disorder comprising obtaining genetic information about a subject's mGluR network genes, and administering a nonselective activator of mGluRs such as fasoracetam if the subject has least one genetic alteration, such as a CNV, in a Tier 1 mGluR network gene. Other embodiments include a method of treating conduct disorder comprising obtaining genetic information about a subject's mGluR network genes, and administering a nonselective activator of mGluRs such as fasoracetam if the subject has at least one genetic alteration, such as a CNV, in a Tier 2 mGluR network gene. Still other embodiments encompass a method of treating conduct disorder comprising obtaining genetic information about a subject's mGluR network genes, and administering a nonselective activator of mGluRs such as fasoracetam if the subject has at least one genetic alteration, such as a CNV, in a Tier 3 mGluR network gene. Subjects having more than one CNV in any one Tier, or in a combination of any of the three Tiers, may be treated by administering a nonselective activator of mGluRs such as fasoracetam. In some embodiments, subjects having conduct disorder, but not having ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, or depression, may be treated. In other method of treatment embodiments of the invention, the subject has one or more neuropsychological disorders such as ADHD, ODD, autism, a mood disorder, anxiety disorder, Tourette's syndrome, phobia, obsessive compulsive disorder (OCD), difficulty controlling anger, disruptive behavior symptoms, dermatillomania, a movement disorder, a developmental disorder, and depression in addition to conduct disorder.

Methods for Determining the Presence or Absence of Genetic Alterations

Any biological sample may be used to determine the presence or absence of mGluR network gene alterations, including, but not limited to, blood, urine, serum, gastric lavage, CNS fluid, any type of cell (such as brain cells, white blood cells, mononuclear cells) or body tissue. Any biological sample whereby DNA can be extracted may be used to determine the presence or absence of mGluR network gene alterations. Samples may be freshly collected, or samples may have been previously collected for any use/purpose and stored until the time of testing for genetic alterations. DNA that was previously purified for a different purpose may also be used.

Various methods for determining genetic alterations are known, including the following:

1. Single Nucleotide Variant (SNV)/Single Nucleotide Polymorphism (SNP) Genotyping

Determining whether a patient has a genetic alteration, such as a CNV, in an mGluR network gene may be done by SNP/SNV Genotyping. A “single nucleotide variant (SNV),” also called a “single nucleotide polymorphism (SNP)” herein, refers to a change in which a single base in the DNA differs from the usual base at that position. Millions of SNVs have been cataloged in the human genome. Some SNVs are normal variations in the genome, while others are associated with disease. While specific SNVs may be associated with disease states or susceptibility, high-density SNV genotyping can also be undertaken, whereby sequencing information on SNVs is used to determine the unique genetic makeup of an individual.

In SNV genotyping, SNVs can be determined by hybridizing complementary DNA probes to the SNV site. A wide range of platforms can be used with SNV genotyping tools to accommodate varying sample throughputs, multiplexing capabilities, and chemistries. In high-density SNV arrays, hundreds of thousands of probes are arrayed on a small chip, such that many SNVs can be interrogated simultaneously when target DNA is processed on the chip. By determining the amount of hybridization of target DNA in a sample to a probe (or redundant probes) on the array, specific SNV alleles can be determined. Use of arrays for SNV genotyping allows the large-scale interrogation of SNVs.

When analyzing CNVs, after SNVs have been analyzed, a computer program can be used to manipulate the SNV data to arrive at CNV data. PennCNV or a similar program, can then be used to detect signal patterns across the genome and identify consecutive genetic markers with copy number changes. (See Wang K, et al. June 2008) Cold Spring Harb Protoc). PennCNV allows for kilobase-resolution detection of CNVs. (See Wang K, et al. (November 2007) Genome Res. 17(11):1665-74).

In CNV analysis, the SNV genotyping data is compared with the behavior of normal diploid DNA. The software uses SNV genotyping data to determine the signal intensity data and SNV allelic ratio distribution and to then use these data to determine when there is deviation from the normal diploid condition of DNA that indicates a CNV. This is done in part by using the log R Ratio (LRR), which is a normalized measure of the total signal intensity for the two alleles of the SNV (Wang 2008). If the software detects regions of contiguous SNVs with intensity (LRR) trending below 0, this indicates a CNV deletion. If the software instead detects regions of contiguous SNVs with intensity (LRR) trending above 0, this indicates a CNV duplication. If no change in LRR is observed compared to the behavior of diploid DNA, the sequence is in the normal diploid state with no CNV present. The software also uses B allele frequency (BAF), a normalized measure of the allelic intensity ratio of two alleles that changes when alleles are lost or gained as with a CNV deletion or duplication. For example, a CNV deletion is indicated by both a decrease in LRR values and a lack of heterozygotes in BAF values. In contrast, a CNV duplication is indicated by both an increase in LRR values and a splitting of the heterozygous genotype BAF clusters into two distinct clusters. The software automates the calculation of LRR and BAF to detect CNV deletions and duplications for whole-genome SNV data. The simultaneous analysis of intensity and genotype data accurately defines the normal diploid state and determines CNVs.

Array platforms such as those from Illumina, Affymetrix, and Agilent may be used in SNV Genotyping. Custom arrays may also be designed and used based on the data described herein.

2. Comparative Genomic Hybridization

Comparative genomic hybridization (CGH) is another method that may be used to evaluate genetic alterations such as CNVs. CGH is a molecular cytogenetic method for analyzing genetic alterations such as CNVs in comparison to a reference sample using competitive fluorescence in situ hybridization (FISH). DNA is isolated from a patient and a reference source and independently labeled with fluorescent molecules (i.e., fluorophores) after denaturation of the DNA. Hybridization of the fluorophores to the resultant samples are compared along the length of each chromosome to identify chromosomal differences between the two sources. A mismatch of colors indicates a gain or loss of material in the test sample in a specific region, while a match of the colors indicates no difference in genetic alterations such as copy number between the test and reference samples at a particular region.

3. Whole Genome Sequencing, Whole Exome Sequencing, and Targeted Sequencing

Whole genome sequencing, whole exome sequencing, or targeted sequencing may also be used to analyze genetic alterations such as CNVs. Whole genome sequencing (also known as full genome sequencing, complete genome sequencing, or entire genome sequencing) involves sequencing of the full genome of a species, including genes that do or do not code for proteins. Whole exome sequencing, in contrast, is sequencing of only the protein-coding genes in the genome (approximately 1% of the genome). Targeted sequencing involves sequencing of only selected parts of the genome.

A wide range of techniques would be known to those skilled in the art to perform whole genome, whole exome, or targeted sequencing with DNA purified from a subject. Similar techniques could be used for different types of sequencing. Techniques used for whole genome sequencing include nanopore technology, fluorophore technology, DNA nanoball technology, and pyrosequencing (i.e., sequencing by synthesis). In particular, next-generation sequencing (NGS) involves sequencing of millions of small fragments of DNA in parallel followed by use of bioinformatics analyses to piece together sequencing data from the fragments.

As whole exome sequencing does not need to sequence as large an amount of DNA as whole genome sequencing, a wider range of techniques are may be used. Methods for whole exome sequencing include polymerase chain reaction methods, NGS methods, molecular inversion probes, hybrid capture using microarrays, in-solution capture, and classical Sanger sequencing. Targeted sequencing allows for providing sequence data for specific genes rather than whole genomes and can use any of the techniques used for other types of sequencing, including specialized microarrays containing materials for sequencing genes of interest.

4. Other Methods for Determining Genetic Alterations

Proprietary methodologies, such as those from BioNano or OpGen, using genome mapping technology can also be used to evaluate genetic alterations such as CNVs.

Standard molecular biology methodologies such as quantitative polymerase chain reaction (PCR), droplet PCR, and TaqMan probes (i.e., hydrolysis probes designed to increase the specificity of quantitative PCR) can be used to assess genetic alterations such as CNVs. Fluorescent in situ hybridization (FISH) probes may also be used to evaluate genetic alterations such as CNVs. The analysis of genetic alterations such as CNVs present in patients with anxiety disorders is not limited by the precise methods whereby the genetic alterations such as CNVs are determined.

Methods for Diagnosing Conduct Disorder Based on CNV Data

In some embodiments, the genetic alteration is an SNV or CNV. The SNV(s) or CNV(s) associated with conduct disorder are found in an mGluR network gene, such as a gene listed in Tier 1, Tier 2, or Tier 3 as shown in FIGS. 2-4 or a set or panel of such genes.

In some embodiments, gene sets of mGluR network genes are used for analyzing samples from patients with or suspected of having conduct disorder. In some embodiments, the presence of CNV duplications or deletions within these gene sets or panels is determined. In some embodiments, CNVs in the Tier 1 genes shown in FIG. 2 are determined. In some embodiments a panel of at least 10, at least 20, at least 30, at least 40, at least 50, at least 60, at least 70, or all 76 of the Tier 1 genes is evaluated for the presence of CNVs. Within any such panel of genes, individual, specific Tier 1 genes may be excluded from the analysis set. Any or all of GRM1-8 may be excluded from the panel, for example.

In some embodiments, the Tier 2 genes as shown in FIG. 3 are analyzed for the presence of genetic alterations such as CNVs. Tier 2 genes are those that are tightly associated with mGluRs, but which are not contained within Tier 1. In some embodiments, the Tier 2 genes are evaluated together with Tier 1 genes. In some embodiments, at least 100 Tier 2 genes are evaluated, while in some embodiments, at least 150, or 197 of the Tier 2 genes are evaluated. Individual, specific Tier 2 genes may be excluded from the gene set for evaluation in some embodiments.

In some embodiments, the 599 Tier 3 genes shown in FIG. 4 are evaluated for genetic alterations such as CNVs. In some embodiments, the Tier 3 genes are evaluated together with Tier 1 and/or Tier 2 genes. In some embodiments, at least 100 Tier 3 genes are evaluated, while in some embodiments, at least 150, 200, 250, 300, 350, 400, 450, or 599 of the Tier 3 genes are evaluated. Individual, specific Tier 3 genes may be excluded from the gene set for evaluation in some embodiments.

Methods of Administration and Combination Therapy

In some embodiments, the agent that modulates mGluR signaling is fasoracetam or fasoracetam monohydrate (also known as C-NS-105, NFC1, NS105, or LAM-105).

Dosing

In some embodiments, fasoracetam may be administered as fasoracetam monohydrate (NFC-1). In some embodiments, fasoracetam may be administered by mouth (i.e., per os). In some embodiments, fasoracetam may be administered as capsules. In some embodiments, fasoracetam capsules may contain 50, 60, 70, 80, 90, 100, 110, 120, 125, 130, 135, 140, 145, 150, 155, 160, 165, 170, 175, 180, 185, 190, 195, or 200 mg of fasoracetam monohydrate. In some embodiments, fasoracetam may be dosed once daily or twice daily. In some embodiments, the daily dose of fasoracetam may be 50 mg once-daily, 100 mg once-daily, 200 mg once-daily, 400 mg once-daily, 50 mg twice-daily, 100 mg twice-daily, 200 mg twice-daily, or 400 mg twice-daily. In some embodiments, fasoracetam dosing may be adjusted using a series of dose escalations. In some embodiments, pharmacokinetic data on drug level or clinical response is used to determine changes in dosing. In some embodiments, dose escalation of fasoracetam is not used. In some embodiments, subjects are treated at a dose of fasoracetam expected to be clinically efficacious without a dose-escalation protocol.

Combination Therapies

In some embodiments, fasoracetam is used in combination with other agents for the treatment of conduct disorder. The other agent used in combination with fasoracetam may be an antipsychotic agent (such as haloperidol, chlorpromazine, amisulpride, aripiprazole, asenapine, blonaserin, clozapine, iloperidone, lurasidone, melperone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, sulpiride, ziprasidone, or zotepine).

In some embodiments, fasoracetam may be used in combination with a non-pharmacologic treatment, such as psychotherapy or brain stimulation therapies. In some embodiments, fasoracetam is used in combination with brain stimulation, which may be vagus nerve stimulation, repetitive transcranial magnetic stimulation, magnetic seizure therapy, deep brain stimulation, or any other therapies involving modulation of brain function by electricity, magnets, or implants.

Articles of Manufacture

In some embodiments, the invention comprises articles of manufacture that may be used in the methods and treatments described herein. In one embodiment, the manufacture is a solid support or microarray for use in detecting genetic alterations in some or all of the mGluR network genes listed in FIGS. 1-3 (i.e., Tiers 1-3). (See also Tables 1-3 herein providing start and stop locations for different mGluR network-related SNPs. This information may be useful in constructing a microarray.) In some embodiments, genes contained in multiple Tiers are assessed within the same solid support or microarray. In some embodiments, certain mGluR network genes are excluded. In some embodiments, the GRM genes are excluded.

Thus, for example, in some embodiments in which mGluR network genes are assayed to determine if there is a genetic alteration in one or more of the genes, such as a CNV, a solid support or microarray, such as on a chip, is used that contains appropriate probes for determining the presence of genetic alterations in 10, 20, 30, 40, 50, 60, 70 or all of the Tier 1 genes. In some embodiments, the probes are labelled. In some embodiments, the probes are labelled with non-natural components. In some embodiments, the solid support or microarray may also include appropriate probes for determining the presence of genetic alterations in at least 10, 20, 30, 50, 100, 150, or all of the Tier 2 genes. In some embodiments, it may further include appropriate probes for determining the presence of genetic alterations in at least 10, 20, 50, 100, 200, 300, 400, 500 or all of the Tier 3 genes. For example, such a solid support, microarray, or chip may be used to determine the presence of genetic alterations such as CNVs or SNVs in the Tier 1, Tier 1+2, or Tier 1+2+3 mGluR gene networks as part of a method of treating an ADHD or 22q deletion and/or duplication patient.

In some embodiments, the manufacture is a set of probes for mGluR network genes of interest from Tiers 1, 2, and/or 3. In some embodiments the probes are labelled. Similarly, sets of probes may be manufactured for determining the presence of genetic alterations in 10, 20, 30, 40, 50, 60, 70 or all of the Tier 1 genes. In some embodiments, probes may be manufactured for determining the presence of genetic alterations in at least 10, 20, 30, 50, 100, 150, or all of the Tier 2 genes. In some embodiments, probes may further include those for determining the presence of genetic alterations in at least 10, 20, 50, 100, 200, 300, 400, 500 or all of the Tier 3 genes. These various probe sets may be used in methods of determining the presence of genetic alterations, such as CNVs and SNVs in the Tier 1, Tier 1+2, or Tier 1+2+3 mGluR gene networks as part of a method of treating an ADHD or 22q deletion and/or duplication patient.

EXAMPLES Example 1. Enrichment of CNV Calls Containing mGluR Network Genes in Samples from Patients with Conduct Disorder

A study of potential enrichment of mGluR network genes was undertaken in patients who had conduct disorder, phobias, depression, or obsessive-compulsive disorder. Given the critical role of mGluRs and their signaling networks, changes in copy number of mGluR network genes may provide new approaches for diagnostics or treatments for psychiatric disorders.

Previously, a large-scale genome association study for copy-number variations enriched in patients with ADHD was performed as described in Elia et al., Nature Genetics, 44(1): 78-84 (2012)). Elia's study included about 2,493 patients with ADHD and about 9,222 controls, all of whom were of European ancestry and were between the ages of 6 to 18 years of age. This study noted that the rate of CNVs that contained an mGluR network gene was 1.2% in the control group, and that this rate increased to 11.3% in ADHD patients.

Samples for the present study were selected based on ICP-9 codes for diagnoses of children and adolescents from electronic health records that were treated at the Children's Hospital of Philadelphia (CHOP). All subjects had been evaluated by a pediatric psychiatrist who had entered a diagnosis of conduct disorder, depression, obsessive-compulsive disorder (OCD), or phobia. FIG. 1 shows the number of patient samples analyzed in each of the conduct disorder, depression, OCD, and phobia groups. Certain patients for each group were fully genotyped as shown in FIG. 1. Data from fully genotyped patients were used for analysis.

Single nucleotide variant (SNV)/single nucleotide polymorphism (SNP) genotype data were used to determine CNVs. SNV genotyping provides a genetic fingerprint of an individual using a large number of SNV markers to provide high-density SNV genotyping data (see Wang K, et al. November 2007) Genome Res. 17(11)):1665-74). HumanHap550 Genotyping BeadChip™ (Illumina) or Human610-Quad v1.0 BeadChip™ (Illumina) were used in this study. For both chips, the same 520 SNVs were analyzed; therefore, data from these two chips are interchangeable. Standard manufacturer protocols were used for all genotyping assays. Illumina readers were used for all experiments.

SNV genotyping data from each fully genotyped patient sample were analyzed with the PennCNV software to determine the signal intensity data and SNV allelic ratio distribution. These data were then used to determine CNVs via simultaneous analysis of intensity and genotype data (as previously described in Wang 2008). Using this analysis, data indicating a region of loss of contiguous SNVs lead to a call of a CNV deletion. Data indicating a region of gain of contiguous SNVs lead to a call of a CNV duplication. A single individual may have multiple CNV deletions/duplications or may not have any CNVs.

As discussed previously, three tiers of mGluR network genes were developed. FIGS. 2-4 show the genes that are included in the three gene sets—Tier 1 (76 genes) in FIG. 2, Tier 2 (197 genes) in FIG. 3, and Tier 3 (599 genes) in FIG. 4. Note that these gene sets were non-inclusive, so a single gene was only contained in a single Tier.

FIG. 5 shows data on the number of CNV calls in each mGluR gene Tier for the different patient groups. CNVs are either a duplication or deletion. The data indicate that a larger number of CNV calls were seen for each gene set of mGluR network genes in the samples from patients with conduct disorder as compared to patients with depression, OCD, and phobia.

The percentage of patients who had a CNV call (either duplication or deletion) in each gene set of mGluR network genes is shown in FIG. 6. These data indicate that a substantially higher percentage of patients with conduct disorder had a CNV call within each of the mGluR network gene sets compared with patients with healthy controls or subjects with depression, phobia, or OCD. The control frequency of patients with CNVs in mGluR network genes has previously been estimated in a large study of over 9,000 controls of European ancestry to be 1.2% (see Elia). Based on data in the present study, the frequency of patients with CNVs for OCD, phobia, or depression was less than 1.6% for Tier 1 mutation positive patients, while the frequency of patients with CNVs in patients with conduct disorder was 11.3% for Tier 1 mutation positive subjects, 16.59%, for Tier 1 and 2 mutation positive subjects, and 34.94% for Tiers 1, 2, and 3 mutation positive subjects. See FIG. 6.

As indicated in FIGS. 5-6, there was a significant enrichment of mGluR network gene alterations in the patients with conduct disorder. Therefore, diagnostics and treatments focused on modulation of mGluR gene networks may be of particular use in patients with conduct disorder.

Example 2. Analysis of mGluR Network Genes Contained within CNVs from Samples of Patients with Conduct Disorder

We next analyzed genotyping data from the 861 fully genotyped patients with conduct disorder to identify the genes associated with the CNVs. The mGluR network genes that are contained within CNVs from this group of patients are presented as examples of genes within the mGluR network that are contained within CNVs either as duplications or deletions.

Table 1 shows data of representative CNVs from patients with conduct disorder wherein a Tier 1 mGluR network gene was located within, or in the vicinity of, a CNV in the patient's sample. CNVs can lead to structural changes that affect the transcription of genes located outside of, but in the vicinity of, the CNV. As such, mGluR network genes within one of the Tiers that were located within 500,000 base pairs of a CNV were also included in the analysis. When an mGluR network gene is contained within the listed CNV, this is noted with a “distance from gene” value of 0. When an mGluR network gene is contained in close proximity to a CNV but not within it, this is presented with a “distance from gene” value of greater than 0.

Table 1 lists the chromosome wherein the CNV was located, with its start and stop location in relation to the Human Genome version 19 (hg19). The number of SNPs located within the CNV is noted as “Num SNP,” and the length of the CNV is noted in base pairs. The StartSNP and EndSNP of the CNV are also provided.

The “State, CN” column indicates the copy number resulting from the CNV. As normal human DNA (i.e. with no CNV) should be diploid and would have a “State, CN” of 2. CNVs with a “State, CN” of 0 or 1 indicate a copy number deletion. In contrast, CNVs with a “State, CN” of three or greater indicate a copy number duplication.

The confidence value indicates the relative confidence that the call of the CNV is correct. All CNVs included in this analysis had a positive confidence value, indicating a high likelihood that the CNV call is correct. A value of 15 or greater was seen for most CNVs and is considered extremely high confidence in the CNV call based on qPCR and Taqman genotyping validation.

In Table 1, the “mGluR gene” column lists the specific mGluR network gene within Tier 1 contained within the listed CNV. Table 1 is sorted to show all of the CNVs that included a given Tier 1 mGluR network gene. Some Tier 1 genes may be represented in multiple CNVs from different patients in the study, leading to multiple rows for those particular mGluR network genes. Some Tier 1 genes may not have been represented in a CNV from this particular patient population.

Table 2 shows data from specific CNVs that contained a Tier 1 or Tier 2 mGluR network gene. The organization of Table 2 follows that of Table 1. The “mGluR gene” column lists the specific mGluR network gene within Tier 1 or Tier 2 contained within the listed CNV. Table 2 is sorted to show all of the CNVs that included a given Tier 1 or Tier 2 mGluR network gene. Some Tier 1 or Tier 2 genes may be represented in multiple CNVs from different patients in the study, leading to multiple rows for those particular genes. Some Tier 1 or Tier 2 genes may not have been represented in a CNV from this particular patient population.

Table 3 shows data from specific CNVs that contained a Tier 1, 2, or 3 mGluR network gene. The organization of Table 3 follows that of Tables 1 and 2. The “mGluR gene” column lists the specific mGluR network gene within Tier 1, Tier 2, or Tier 3 contained within the listed CNV. Table 3 is sorted to show all the CNVs that included a given Tier 1, 2, or 3 mGluR network gene. Some Tier 1, 2, or 3 genes may be represented in multiple CNVs from different patients in the study, leading to multiple rows for those particular mGluR network genes. Some Tier 1, 2, or 3 genes may not have been represented in a CNV from this particular patient population.

Together, the data in Tables 1-3 indicate that a wide variety of mGluR network genes contained within each Tier are present in CNVs from patients with conduct disorder. If a larger patient cohort with conduct disorder phenotype was genotyped, all the genes in Tier-1, Tier-2, and Tier-3 would show enrichment for CNVs in patients with conduct disorder.

TABLE 1 Distance Chr: Start-Stop(hg19) NumSNP Length State, CN StartSNP EndSNP Confidence From Gene mGluR Gene chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 ACAT1 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 ACAT1 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 ACAT1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 ACCN1 chr2: 54984424-67416189 2413 12431766 3 rs980644 rs12473913 14.927 0 ACTR2 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 ACTR2 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 ACTR2 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 ACTR2 chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 ACTR2 chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 ADCY1 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 ADCY1 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 ADCY1 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 ADCY1 chr7: 44112529-45698253 270 1585725 1 rs7778745 rs2960288 51.042 0 ADCY1 chr11: 65226187-67799926 252 2573740 1 rs1626021 rs2075626 54.033 0 ADRBK1 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 ADRBK1 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 ADRBK1 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 ADRBK1 chr11: 66842469-67046501 18 204033 1 rs11227678 rs12274774 20.038 0 ADRBK1 chr16: 28301487-31147548 157 2846062 1 rs9939450 rs2855475 36.755 0 ALDOA chr16: 29130999-33612830 601 4481832 3 rs12922496 rs2067108 21.218 0 ALDOA chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 ALDOA chr16: 28642242-33612830 684 4970589 4 rs34954049 rs2067108 4.025 0 ALDOA chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 APP chr21: 25452702-29545417 1017 4092716 3 rs2019006 rs2831606 41.533 0 APP chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 APP chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 APP chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 APP chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 APP chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 APP chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 APP chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 APP chr21: 14569317-28194874 3308 13625558 3 rs1772304 rs7278460 1086.833 0 APP chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 APP chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 APP chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 APP chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 APP chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 ARL15 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 ARL15 chr5: 52884614-53418318 145 533705 1 rs524289 rs9292039 31.471 0 ARL15 chr17: 42223914-42423665 22 199752 1 rs12603404 rs3785817 49.315 0 ATXN7L3 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 ATXN7L3 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 ATXN7L3 chr14: 92414380-101757695 2557 9343316 3 rs3814835 rs4906092 19.826 0 BDKRB2 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 BDKRB2 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 BDKRB2 chr8: 53363937-64107847 2115 10743911 3 rs284818 rs2043525 25.971 0 CA8 chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 CA8 chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 CA8 chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 CA8 chr8: 60654261-60775727 18 121467 1 rs1949102 rs7822560 11.681 325696 CA8 chr9: 138873600-140938183 302 2064584 1 cnvi0002612 rs3750506 26.611 0 CACNA1B chr1: 164144117-180071987 3186 15927871 3 rs12037444 rs6425606 30.846 0 CACYBP chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 CACYBP chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 CACYBP chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 CACYBP chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 CACYBP chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 CALM1 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 CALM1 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 CALM1 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 CHRM3 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 CHRM3 chr1: 239472077-239774670 62 302594 3 rs12041476 rs6685121 100.034 0 CHRM3 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 CHRM3 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 CIC chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 CIC chr19: 40344648-46426076 806 6081429 1 rs12609590 rs8101540 27.283 0 CIC chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 CIC chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 CIC chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 CIC chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 CIC chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 CNP chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 CNP chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 CNTN4 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 CNTN4 chr3: 1745013-1933220 90 188208 1 rs2314772 rs6795047 270.212 207330 CNTN4 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 CRHR1 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 CRHR1 chr17: 43657921-44354796 88 696876 3 rs9898857 rs2732700 28.613 0 CRHR1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 CTNNA2 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 CTNNA2 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 CTNNA2 chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 CTNNA2 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 DISC1 chr1: 231711489-231813134 22 101646 3 rs1765782 rs6541281 33.828 0 DISC1 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 DISC1 chr1: 231669827-231819050 26 149224 1 rs1655290 rs1417584 16.629 0 DISC1 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 DISC1 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 DPP6 chr7: 153694399-153811655 11 117257 3 rs10235799 rs3115192 12.729 0 DPP6 chr7: 153231745-153788895 99 557151 3 rs3111283 rs2109329 250.628 0 DPP6 chr7: 153487944-153707385 46 219442 3 rs2098112 rs17134265 131.848 0 DPP6 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 DYNLL1 chr12: 112610714-133708729 5366 21098016 3 rs11066188 rs11147249 695.45 0 DYNLL1 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 FPR1 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 FPR1 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 FPR1 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 FPR1 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 FPR1 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 GAPDH chr19: 3053574-18061509 2612 15007936 3 rs7938 rs7250332 73.169 0 GNA15 chr19: 1961474-14570703 2131 12609230 1 rs2041120 rs12974686 29.276 0 GNA15 chr19: 384644-4514135 854 4129492 1 rs12151104 rs4807598 56.902 0 GNA15 chr19: 1572369-3354956 351 1782588 1 rs10415156 rs4807451 45.225 0 GNA15 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 GNAI2 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 GNAI2 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 GNAI2 chr3: 46713865-52833805 488 6119941 1 rs3935248 rs3617 54.926 0 GNAI2 chr16: 56362725-57226956 220 864232 3 rs2241952 rs6499871 11.443 0 GNAO1 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 GNAO1 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 GNAQ chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 GNAQ chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 GNAQ chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 GNAQ chr9: 77857783-82347458 1181 4489676 1 rs12000663 rs4387054 36.701 0 GNAQ chr9: 80201301-80528757 54 327457 1 rs1162211 rs7033572 30.324 0 GNAQ chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 GRIK1 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 GRIK1 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 GRIK1 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 GRIK1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 GRIK1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 GRIK1 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 GRIK1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 GRIK1 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 GRIK1 chr21: 27808458-44731138 4502 16922681 1 rs150760 rs504022 45.745 0 GRIK1 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 GRIK1 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 GRIK1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 GRIK1 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 GRIK1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 GRIK3 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 GRIK3 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 GRM1 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 GRM1 chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 GRM1 chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 GRM1 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 GRM1 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 GRM1 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 GRM1 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 GRM1 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 GRM1 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 GRM1 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 GRM1 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 GRM1 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 GRM1 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 GRM1 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 GRM1 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 GRM1 chr7: 73178435-89984409 2908 16805975 4 rs11764572 rs42664 0.17 0 GRM3 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 GRM3 chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 GRM3 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 GRM3 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 GRM3 chr7: 86022840-86137490 20 114651 1 rs3903590 rs6980352 14.813 135740 GRM3 chr11: 88533414-91714466 456 3181053 4 rs10501688 rs7940613 8.733 0 GRM5 chr11: 88533414-91714466 456 3181053 4 rs10501688 rs7940613 8.733 0 GRM5 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 GRM5 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 GRM5 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 GRM5 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 GRM5 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 GRM5 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 GRM5 chr11: 88325804-88962090 140 636287 1 rs1504088 rs11018542 30.5 0 GRM5 chr11: 88325804-88962090 140 636287 1 rs1504088 rs11018542 30.5 0 GRM5 chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 GRM7 chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 GRM7 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 GRM7 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 GRM7 chr7: 126354618-131010943 857 4656326 3 rs1018878 rs3823483 28.648 0 GRM8 chr7: 126354618-131010943 857 4656326 3 rs1018878 rs3823483 28.648 0 GRM8 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 GRM8 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 GRM8 chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 GRM8 chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 GRM8 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 GRM8 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 GRM8 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 GRM8 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 GRM8 chr7: 117831743-152070158 6055 34238416 3 rs3808178 rs6966258 7.28 0 GRM8 chr7: 117831743-152070158 6055 34238416 3 rs3808178 rs6966258 7.28 0 GRM8 chr7: 125999649-126219766 52 220118 1 rs714237 rs2299470 25.109 0 GRM8 chr7: 125999649-126219766 52 220118 1 rs714237 rs2299470 25.109 0 GRM8 chr7: 125676925-125927493 48 250569 1 rs1419535 rs17600450 37.913 151159 GRM8 chr7: 125676925-125927493 48 250569 1 rs1419535 rs17600450 37.913 151159 GRM8 chr7: 125676925-125780682 24 103758 1 rs1419535 rs10267757 26.358 297970 GRM8 chr7: 125676925-125780682 24 103758 1 rs1419535 rs10267757 26.358 297970 GRM8 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 GSN chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 GSN chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 GSN chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 GSN chr5: 73958245-81276023 1632 7317779 3 rs4703640 rs4703863 22.731 0 HOMER1 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 HOMER1 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 HOMER1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 HOMER1 chr5: 76450190-79622472 726 3172283 1 rs6864250 rs2405378 35.823 0 HOMER1 chr5: 78542290-79057477 95 515188 1 rs10474578 rs259126 38.26 0 HOMER1 chr13: 19496434-50144613 7295 30648180 3 rs1838114 rs11148151 43.395 0 HTR2A chr13: 34752890-109100024 15589 74347135 1 rs2321822 rs7332707 33.721 0 HTR2A chr13: 41369790-112329394 15030 70959605 3 rs1536807 rs9588495 26.915 0 HTR2A chr13: 46975365-56115403 1925 9140039 1 rs7333428 rs9537164 28.591 0 HTR2A chr4: 108454525-114225831 1057 5771307 3 rs1877863 rs29311 22.746 0 LARP7 chr4: 113393443-113736980 48 343538 1 rs1486860 rs6853702 18.447 0 LARP7 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 LARP7 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 LARP7 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 LARP7 chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 LARP7 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 LARP7 chr4: 113385223-113578609 25 193387 1 cnvi0012240 rs1129065 19.233 0 LARP7 chr22: 19413706-51123505 7927 31709800 3 rs9618567 rs9616816 6.837 0 MAPK1 chr22: 19765182-43845708 5546 24080527 1 rs4819843 rs135044 57.345 0 MAPK1 chr22: 17394989-22573637 1104 5178649 3 rs1860945 rs12159423 32.25 0 MAPK1 chr22: 18877787-23040362 1092 4162576 3 rs2543958 rs5996349 1181.316 0 MAPK1 chr22: 21939675-22971768 397 1032094 1 rs5754217 rs9620151 562.05 0 MAPK1 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 MTHFD1 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 MTHFD1 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 MTHFD1 chr14: 64926097-65063315 19 137219 1 rs2281603 rs10134770 14.377 0 MTHFD1 chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 MX1 chr21: 41509457-47941916 1911 6432460 3 rs741802 rs2096507 27.753 0 MX1 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 MX1 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 MX1 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 MX1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 MX1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 MX1 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 MX1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 MX1 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 MX1 chr21: 27808458-44731138 4502 16922681 1 rs150760 rs504022 45.745 0 MX1 chr21: 37312170-45589727 2506 8277558 1 rs1573303 rs4818886 41.534 0 MX1 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 MX1 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 MX1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 MX1 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 MX1 chr1: 69926258-81391541 1911 11465284 4 rs1926269 rs17105699 11.774 0 NEGR1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 NEGR1 chr1: 71362814-72683226 306 1320413 1 rs35184114 rs1675356 35.617 0 NEGR1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 NEGR1 chr1: 72540901-72766085 35 225185 1 rs12033161 rs9424981 18.022 0 NEGR1 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 NLN chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 NLN chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 NLN chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 NMI chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 NMI chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 NMI chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 NMI chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 PCBP3 chr21: 41509457-47941916 1911 6432460 3 rs741802 rs2096507 27.753 0 PCBP3 chr21: 46466674-47652185 275 1185512 1 rs4819020 rs2839160 84.642 0 PCBP3 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 PCBP3 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 PCBP3 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 PCBP3 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 PCBP3 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 PCBP3 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 PCBP3 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 PCBP3 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 PCBP3 chr21: 44744540-47642272 785 2897733 1 rs10084596 rs2280957 41.824 0 PCBP3 chr21: 47091361-47265786 27 174426 1 rs2838973 rs1009577 13.147 0 PCBP3 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 PCBP3 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 PCBP3 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 PCBP3 chr21: 46381900-48098560 448 1716661 1 rs8132265 cnvi0019195 712.68 0 PCBP3 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 PCBP3 chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 PDE1C chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 PDE1C chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 PDE1C chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 PPP2R1A chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 PPP2R1A chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 PPP2R1A chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 PPP2R1A chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 PPP2R1A chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 PRPSAP1 chr17: 74204592-79532654 1324 5328063 1 rs4505373 rs3934711 38.57 0 PRPSAP1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 PRPSAP1 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 PRPSAP1 chr17: 67081830-78829375 2912 11747546 1 rs2302134 rs12943041 31.498 0 PRPSAP1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 PSMD11 chr11: 198510-5875867 1467 5677358 3 rs3802985 rs2045046 49.035 0 PSMD13 chr11: 219089-1139111 206 920023 1 rs511744 rs11245979 38.286 0 PSMD13 chr12: 120396295-120709064 35 312770 1 rs4767865 rs3999561 29.821 0 PXN chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 PXN chr12: 112610714-133708729 5366 21098016 3 rs11066188 rs11147249 695.45 0 PXN chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 QRICH2 chr17: 74204592-79532654 1324 5328063 1 rs4505373 rs3934711 38.57 0 QRICH2 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 QRICH2 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 QRICH2 chr17: 67081830-78829375 2912 11747546 1 rs2302134 rs12943041 31.498 0 QRICH2 chr22: 19413706-51123505 7927 31709800 3 rs9618567 rs9616816 6.837 0 RANBP1 chr22: 19765182-43845708 5546 24080527 1 rs4819843 rs135044 57.345 0 RANBP1 chr22: 18877787-21462353 510 2584567 1 rs2543958 rs140392 1090.228 0 RANBP1 chr22: 17394989-22573637 1104 5178649 3 rs1860945 rs12159423 32.25 0 RANBP1 chr22: 18877787-23040362 1092 4162576 3 rs2543958 rs5996349 1181.316 0 RANBP1 chr22: 18877787-21462353 512 2584567 1 rs2543958 rs140392 360.702 0 RANBP1 chr22: 19025381-20228542 296 1203162 1 rs6623 rs701428 38.244 0 RANBP1 chr22: 19735854-20155192 142 419339 1 rs6518580 rs373747 36.567 0 RANBP1 chr22: 18877787-21461274 612 2583488 3 rs2543958 rs140391 1388.235 0 RANBP1 chr22: 19613784-21462353 380 1848570 3 rs5993743 rs140392 153.49 0 RANBP1 chr13: 60985192-114224496 12638 53239305 1 rs1341840 rs4907646 40.079 0 RAP2A chr13: 34752890-109100024 15589 74347135 1 rs2321822 rs7332707 33.721 0 RAP2A chr13: 41369790-112329394 15030 70959605 3 rs1536807 rs9588495 26.915 0 RAP2A chr13: 63692683-113075599 10941 49382917 1 rs9592243 rs9550080 27.124 0 RAP2A chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 RCC1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 RCC1 chr4: 415311-15136380 3262 14721070 3 rs7695712 rs2702525 10.287 0 RGS12 chr4: 1224811-7063524 1270 5838714 1 rs4974574 rs6836129 27.935 0 RGS12 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 RGS12 chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 RIF1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 RIF1 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 RIF1 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 RIF1 chr2: 152251363-152423605 27 172243 1 rs10173597 rs3732311 11.735 0 RIF1 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 RUVBL2 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 RUVBL2 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 RUVBL2 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 RUVBL2 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 RUVBL2 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 RUVBL2 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 RYR1 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 RYR1 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 RYR1 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 RYR1 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 RYR1 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 RYR1 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 RYR2 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 RYR2 chr1: 237310139-239159611 464 1849473 1 rs2490371 rs1915278 47.032 0 RYR2 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 RYR2 chr1: 237584925-237904870 86 319946 1 rs4593814 rs10925504 31.95 0 RYR2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 SDC3 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 SDC3 chr1: 164144117-180071987 3186 15927871 3 rs12037444 rs6425606 30.846 0 SELE chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 SELE chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 SELE chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 SELE chr6: 428722-31742590 1987 31313869 3 rs1473602 rs707928 44.729 0 SERPINB9 chr6: 2681610-31453618 81 28772009 1 rs1131896 rs9267212 428.052 0 SERPINB9 chr6: 1171596-29892436 39 28720841 1 rs3128994 rs9259806 33.185 0 SERPINB9 chr6: 1165092-29899147 56 28734056 0 rs3128864 rs2394704 57.657 0 SERPINB9 chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 40.382 0 SERPINB9 chr6: 2681610-31453113 80 28771504 3 rs1131896 rs2904600 359.691 0 SERPINB9 chr6: 1171596-29899147 47 28727552 0 rs3128994 rs2394704 61.991 0 SERPINB9 chr6: 2681610-31453618 81 28772009 3 rs1131896 rs9267212 390.234 0 SERPINB9 chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 34.598 0 SERPINB9 chr6: 1171596-29892436 39 28720841 1 rs3128994 rs9259806 31.699 0 SERPINB9 chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 SETD4 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 SETD4 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 SETD4 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 SETD4 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 SETD4 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 SETD4 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 SETD4 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 SETD4 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 SETD4 chr21: 27808458-44731138 4502 16922681 1 rs150760 rs504022 45.745 0 SETD4 chr21: 37312170-45589727 2506 8277558 1 rs1573303 rs4818886 41.534 0 SETD4 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 SETD4 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 SETD4 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 SETD4 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 SETD4 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 SGTB chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 SGTB chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 SGTB chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 SHANK1 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 SHANK1 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 SHANK1 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 SHANK1 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 SHANK1 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 SLC7A10 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 SLC7A10 chr19: 33647379-33821248 45 173870 1 rs11881580 rs7253865 46.991 0 SLC7A10 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 SLC7A10 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 SLC7A10 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 SLC7A10 chr15: 40561890-65059651 4763 24497762 1 rs6492939 rs1008917 60.034 0 SORD chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 SORD chr12: 11740163-33217793 5315 21477631 3 rs10491981 rs12424662 69.717 0 STRAP chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 STRAP chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 TK1 chr17: 74204592-79532654 1324 5328063 1 rs4505373 rs3934711 38.57 0 TK1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 TK1 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 TK1 chr17: 67081830-78829375 2912 11747546 1 rs2302134 rs12943041 31.498 0 TK1 chr3: 160836006-176261513 2782 15425508 4 rs1599389 rs1377820 17.004 0 TNIK chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 TNIK chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 TNIK chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 TNIK chr3: 161695760-196993693 7208 35297934 1 rs4575917 rs406284 54.788 0 TNIK chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 TNIK chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 USP24 chr1: 55523984-55656088 17 132105 1 rs584626 rs13353012 14.983 0 USP24 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 USP24 chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 VHL chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 VHL chr3: 9972493-10372840 66 400348 1 rs279545 rs26310 30.958 0 VHL

TABLE 2 Distance Chr: Start-Stop(hg19) NumSNP Length State, CN StartSNP EndSNP Confidence From Gene mGluR Gene chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 ACAT1 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 ACAT1 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 ACAT1 chr6: 146892943-169478886 6121 22585944 3 rs12199886 rs13219463 43.565 0 ACAT2 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 ACAT2 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 ACAT2 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 ACAT2 chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 ACAT2 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 ACCN1 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 ACCN2 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 ACCN2 chr2: 89910-272926 44 183017 3 rs300789 rs12714402 129.774 0 ACP1 chr2: 54984424-67416189 2413 12431766 3 rs980644 rs12473913 14.927 0 ACTR2 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 ACTR2 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 ACTR2 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 ACTR2 chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 ACTR2 chr20: 34817545-44483225 1946 9665681 1 rs17093449 rs6130947 4536.622 0 ADA chr20: 39998520-43592248 934 3593729 1 rs6072353 rs2868218 29.278 0 ADA chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 ADCY1 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 ADCY1 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 ADCY1 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 ADCY1 chr7: 44112529-45698253 270 1585725 1 rs7778745 rs2960288 51.042 0 ADCY1 chr4: 415311-15136380 3262 14721070 3 rs7695712 rs2702525 10.287 0 ADD1 chr4: 1224811-7063524 1270 5838714 1 rs4974574 rs6836129 27.935 0 ADD1 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 ADD1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 ADD2 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 ADD2 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 ADD2 chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 ADD2 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 ADORA1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 ADORA1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 ADORA1 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 ADORA1 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 ADORA1 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 ADORA1 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 ADRA1B chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 ADRA1B chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 ADRA1B chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 ADRA1B chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 ADRA2A chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 ADRA2A chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 ADRA2A chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 ADRA2A chr10: 99160152-130771382 6972 31611231 3 rs1048442 rs12258650 21.306 0 ADRA2A chr4: 415311-15136380 3262 14721070 3 rs7695712 rs2702525 10.287 0 ADRA2C chr4: 1224811-7063524 1270 5838714 1 rs4974574 rs6836129 27.935 0 ADRA2C chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 ADRA2C chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 ADRB2 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 ADRB2 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 ADRB2 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 ADRB2 chr11: 65226187-67799926 252 2573740 1 rs1626021 rs2075626 54.033 0 ADRBK1 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 ADRBK1 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 ADRBK1 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 ADRBK1 chr11: 66842469-67046501 18 204033 1 rs11227678 rs12274774 20.038 0 ADRBK1 chr16: 28301487-31147548 157 2846062 1 rs9939450 rs2855475 36.755 0 ALDOA chr16: 29130999-33612830 601 4481832 3 rs12922496 rs2067108 21.218 0 ALDOA chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 ALDOA chr16: 28642242-33612830 684 4970589 4 rs34954049 rs2067108 4.025 0 ALDOA chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 ANXA2 chr15: 40561890-65059651 4763 24497762 1 rs6492939 rs1008917 60.034 0 ANXA2 chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 ANXA2 chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 ANXA2 chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 ANXA2 chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 APP chr21: 25452702-29545417 1017 4092716 3 rs2019006 rs2831606 41.533 0 APP chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 APP chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 APP chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 APP chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 APP chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 APP chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 APP chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 APP chr21: 14569317-28194874 3308 13625558 3 rs1772304 rs7278460 1086.833 0 APP chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 APP chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 APP chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 APP chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 APP chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 APTX chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 APTX chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 APTX chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 AQP1 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 AQP1 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 AQP1 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 ARHGAP24 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 ARHGAP24 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 ARHGAP24 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 ARHGAP24 chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 ARHGAP24 chr4: 31619950-97811299 11610 66191350 1 rs6811437 rs12644209 44.41 0 ARHGAP24 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 ARL15 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 ARL15 chr5: 52884614-53418318 145 533705 1 rs524289 rs9292039 31.471 0 ARL15 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 ARRB1 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 ARRB1 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 ARRB1 chr17: 42223914-42423665 22 199752 1 rs12603404 rs3785817 49.315 0 ATXN7L3 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 ATXN7L3 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 ATXN7L3 chr14: 92414380-101757695 2557 9343316 3 rs3814835 rs4906092 19.826 0 BDKRB1 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 BDKRB1 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 BDKRB1 chr14: 92414380-101757695 2557 9343316 3 rs3814835 rs4906092 19.826 0 BDKRB2 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 BDKRB2 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 BDKRB2 chr19: 266034-2771641 432 2505608 4 rs2312724 rs741103 15.34 0 BTBD2 chr19: 1961474-14570703 2131 12609230 1 rs2041120 rs12974686 29.276 0 BTBD2 chr19: 384644-4514135 854 4129492 1 rs12151104 rs4807598 56.902 0 BTBD2 chr19: 1572369-3354956 351 1782588 1 rs10415156 rs4807451 45.225 0 BTBD2 chr19: 1505874-2123516 98 617643 1 rs197198 rs2072304 26.337 0 BTBD2 chr19: 1920342-2050823 26 130482 3 rs4807169 rs3746101 85.52 0 BTBD2 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 BTG2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 BTG2 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 BTG2 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 BTG2 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 BTG2 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 BTG2 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 C1orf116 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 C1orf116 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 C1orf116 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 C1orf116 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 C1orf116 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 C1orf116 chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 C7orf25 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 C7orf25 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 C7orf25 chr8: 53363937-64107847 2115 10743911 3 rs284818 rs2043525 25.971 0 CA8 chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 CA8 chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 CA8 chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 CA8 chr8: 60654261-60775727 18 121467 1 rs1949102 rs7822560 11.681 325696 CA8 chr9: 138873600-140938183 302 2064584 1 cnvi0002612 rs3750506 26.611 0 CACNA1B chr1: 164144117-180071987 3186 15927871 3 rs12037444 rs6425606 30.846 0 CACYBP chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 CACYBP chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 CACYBP chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 CACYBP chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 CACYBP chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 CALB2 chr16: 69829875-88530172 5884 18700298 1 rs4985547 rs4782368 30.145 0 CALB2 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 CALM1 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 CALM1 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 CALM1 chr2: 42287306-50902931 2298 8615626 3 rs988958 rs2194390 44.151 0 CALM2 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 CALM2 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 CALM2 chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 CALM2 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 CALM3 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 CALM3 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 CALM3 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 CALM3 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 CALM3 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 CALM3 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 CALM3 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 CALM3 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 CALM3 chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 CAMK1 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 CAMK1 chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 CAMK2B chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 CAMK2B chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 CAMK2B chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 CAMK2B chr7: 44112529-45698253 270 1585725 1 rs7778745 rs2960288 51.042 0 CAMK2B chr5: 106749690-117695003 2459 10945314 3 rs6868410 rs6882527 55.105 0 CAMK4 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 CAMK4 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 CAMK4 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 CAMK4 chr5: 108284342-111242002 627 2957661 1 rs3797817 rs17133870 44.164 0 CAMK4 chr5: 68234769-70811821 12971 2577053 4 rs6449986 rs279322 2.672 0 CCNB1 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 CCNB1 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 CCNB1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 CCNB1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 CDC42 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 CDC42 chr15: 40561890-65059651 4763 24497762 1 rs6492939 rs1008917 60.034 0 CHP chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 CHP chr15: 40528155-42166500 240 1638346 1 rs1017843 rs12593397 85.352 0 CHP chr15: 41457623-41562393 23 104771 1 rs496142 rs16971734 10.768 0 CHP chr7: 136375979-137102498 151 726520 4 rs10954541 rs1647189 5.931 0 CHRM2 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 CHRM2 chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 CHRM2 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 CHRM2 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 CHRM2 chr7: 117831743-152070158 6055 34238416 3 rs3808178 rs6966258 7.28 0 CHRM2 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 CHRM3 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 CHRM3 chr1: 239472077-239774670 62 302594 3 rs12041476 rs6685121 100.034 0 CHRM3 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 CHRM3 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 CIC chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 CIC chr19: 40344648-46426076 806 6081429 1 rs12609590 rs8101540 27.283 0 CIC chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 CIC chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 CIC chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 CIC chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 CIC chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 CNP chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 CNP chr6: 88318883-101197953 2546 12879071 3 rs2307389 rs1336244 20.983 0 CNR1 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 CNR1 chr6: 69745723-124631456 10981 54885734 1 rs2225803 rs932600 38.287 0 CNR1 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 CNR1 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 CNR1 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 CNR1 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 CNR1 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 CNR1 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 CNR1 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 CNR1 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 COPB2 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 COPB2 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 COPB2 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 COPB2 chr3: 94377411-140094984 8050 45717574 3 rs9844990 rs7618673 46.041 0 COPB2 chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 COPB2 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 CRHR1 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 CRHR1 chr17: 43657921-44354796 88 696876 3 rs9898857 rs2732700 28.613 0 CRHR1 chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 CYCS chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 CYCS chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 CYCS chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 DCN chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 DCN chr12: 84152210-113464649 5560 29312440 1 rs10862748 rs16942470 28.181 0 DCN chr12: 91427784-91630155 39 202372 1 rs2897929 rs1522430 13.426 0 DCN chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 DHCR7 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 DHCR7 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 DHCR7 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 DISC1 chr1: 231711489-231813134 22 101646 3 rs1765782 rs6541281 33.828 0 DISC1 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 DISC1 chr1: 231669827-231819050 26 149224 1 rs1655290 rs1417584 16.629 0 DISC1 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 DISC1 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 DLST chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 DLST chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 DLST chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 DRD2 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 DRD2 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 DRD2 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 DRD3 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 DRD3 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 DRD3 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 DRD3 chr3: 94377411-140094984 8050 45717574 3 rs9844990 rs7618673 46.041 0 DRD3 chr3: 95055435-114675646 3559 19620212 1 rs2871719 rs16823416 41.186 0 DRD3 chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 DRD3 chr20: 6111569-21985498 4344 15873930 3 rs6038366 rs6047798 43.161 0 DSTN chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 DYNLL1 chr12: 112610714-133708729 5366 21098016 3 rs11066188 rs11147249 695.45 0 DYNLL1 chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 ECHS1 chr10: 133970588-135225666 210 1255079 1 rs870552 rs10857712 64.995 0 ECHS1 chr10: 134741143-135357239 169 616097 1 rs12242379 rs1536826 34.134 0 ECHS1 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 EGFR chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 EGFR chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 EGFR chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 ERBB2 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 ERBB2 chr5: 73958245-81276023 1632 7317779 3 rs4703640 rs4703863 22.731 0 F2R chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 F2R chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 F2R chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 F2R chr5: 73958245-81276023 1632 7317779 3 rs4703640 rs4703863 22.731 0 F2RL2 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 F2RL2 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 F2RL2 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 F2RL2 chr19: 3053574-18061509 2612 15007936 3 rs7938 rs7250332 73.169 0 F2RL3 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 F2RL3 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 F2RL3 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 F2RL3 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 F3 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 F3 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 F3 chr14: 38111870-49524522 1996 11412653 4 rs177852 rs2273387 32.638 0 FKBP3 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 FKBP3 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 FKBP3 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 FPR1 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 FPR1 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 FPR1 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 FPR1 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 FPR1 chr15: 72136872-102040672 6413 29903801 3 rs4777466 rs7179692 18.158 0 FURIN chr15: 91379999-91525197 28 145199 1 rs7171099 rs2301826 30.169 0 FURIN chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 FURIN chr15: 73186518-94501564 4223 21315047 1 rs1947219 rs4344687 34.841 0 FURIN chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 FYN chr6: 69745723-124631456 10981 54885734 1 rs2225803 rs932600 38.287 0 FYN chr6: 93575149-115508938 4238 21933790 1 rs4707762 cnvi0021859 41.857 0 FYN chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 FYN chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 FYN chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 FYN chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 FYN chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 FYN chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 FYN chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 FYN chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 GAPDH chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 GLP1R chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 GLP1R chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 GLP1R chr19: 3053574-18061509 2612 15007936 3 rs7938 rs7250332 73.169 0 GNA15 chr19: 1961474-14570703 2131 12609230 1 rs2041120 rs12974686 29.276 0 GNA15 chr19: 384644-4514135 854 4129492 1 rs12151104 rs4807598 56.902 0 GNA15 chr19: 1572369-3354956 351 1782588 1 rs10415156 rs4807451 45.225 0 GNA15 chr7: 73178435-89984409 2908 16805975 4 rs11764572 rs42664 0.17 0 GNAI1 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 GNAI1 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 GNAI1 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 GNAI1 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 GNAI2 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 GNAI2 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 GNAI2 chr3: 46713865-52833805 488 6119941 1 rs3935248 rs3617 54.926 0 GNAI2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 GNAI3 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 GNAI3 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 GNAI3 chr16: 56362725-57226956 220 864232 3 rs2241952 rs6499871 11.443 0 GNAO1 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 GNAO1 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 GNAQ chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 GNAQ chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 GNAQ chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 GNAQ chr9: 77857783-82347458 1181 4489676 1 rs12000663 rs4387054 36.701 0 GNAQ chr9: 80201301-80528757 54 327457 1 rs1162211 rs7033572 30.324 0 GNAQ chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 GOT1 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 GOT1 chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 GOT1 chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 GOT1 chr10: 99160152-130771382 6972 31611231 3 rs1048442 rs12258650 21.306 0 GOT1 chr17: 4739161-4891956 27 152796 3 rs9900036 rs426475 13.756 0 GP1BA chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 GPR26 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 GPR26 chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 GPR26 chr10: 99160152-130771382 6972 31611231 3 rs1048442 rs12258650 21.306 0 GPR26 chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 GRB2 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 GRB2 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 GRB2 chr17: 67081830-78829375 2912 11747546 1 rs2302134 rs12943041 31.498 0 GRB2 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 GRB7 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 GRB7 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 GRIA1 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 GRIA1 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 GRIA1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 GRIA1 chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 GRIK1 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 GRIK1 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 GRIK1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 GRIK1 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 GRIK1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 GRIK1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 GRIK1 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 GRIK1 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 GRIK1 chr21: 27808458-44731138 4502 16922681 1 rs150760 rs504022 45.745 0 GRIK1 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 GRIK1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 GRIK1 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 GRIK1 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 GRIK1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 GRIK3 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 GRIK3 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 GRM1 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 GRM1 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 GRM1 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 GRM1 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 GRM1 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 GRM1 chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 GRM1 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 GRM1 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 GRM2 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 GRM2 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 GRM2 chr3: 46713865-52833805 488 6119941 1 rs3935248 rs3617 54.926 0 GRM2 chr7: 73178435-89984409 2908 16805975 4 rs11764572 rs42664 0.17 0 GRM3 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 GRM3 chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 GRM3 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 GRM3 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 GRM3 chr7: 86022840-86137490 20 114651 1 rs3903590 rs6980352 14.813 135740 GRM3 chr6: 29877864-35562640 12719 5684777 3 rs28592582 rs3798346 61.622 0 GRM4 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 GRM4 chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 GRM4 chr11: 88533414-91714466 456 3181053 4 rs10501688 rs7940613 8.733 0 GRM5 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 GRM5 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 GRM5 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 GRM5 chr11: 88325804-88962090 140 636287 1 rs1504088 rs11018542 30.5 0 GRM5 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 GRM6 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 GRM6 chr5: 176010125-180058963 954 4048839 1 rs936912 rs2290983 30.904 0 GRM6 chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 GRM7 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 GRM7 chr7: 126354618-131010943 857 4656326 3 rs1018878 rs3823483 28.648 0 GRM8 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 GRM8 chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 GRM8 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 GRM8 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 GRM8 chr7: 117831743-152070158 6055 34238416 3 rs3808178 rs6966258 7.28 0 GRM8 chr7: 125676925-125927493 48 250569 1 rs1419535 rs17600450 37.913 151159 GRM8 chr7: 125999649-126219766 52 220118 1 rs714237 rs2299470 25.109 0 GRM8 chr7: 125676925-125780682 24 103758 1 rs1419535 rs10267757 26.358 297970 GRM8 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 GSN chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 GSN chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 GSN chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 GSN chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 HBXIP chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 HBXIP chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 HBXIP chr5: 73958245-81276023 1632 7317779 3 rs4703640 rs4703863 22.731 0 HOMER1 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 HOMER1 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 HOMER1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 HOMER1 chr5: 76450190-79622472 726 3172283 1 rs6864250 rs2405378 35.823 0 HOMER1 chr5: 78542290-79057477 95 515188 1 rs10474578 rs259126 38.26 0 HOMER1 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 HOMER3 chr19: 18892728-19054720 20 161993 1 rs10038 rs4808883 49.554 0 HOMER3 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 HOMER3 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 HOMER3 chr6: 41773322-45545975 754 3772654 3 rs2153878 rs7764616 22.895 0 HSP90AB1 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 HSP90AB1 chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 HSP90AB1 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 HSP90AB1 chr13: 19496434-50144613 7295 30648180 3 rs1838114 rs11148151 43.395 0 HTR2A chr13: 34752890-109100024 15589 74347135 1 rs2321822 rs7332707 33.721 0 HTR2A chr13: 41369790-112329394 15030 70959605 3 rs1536807 rs9588495 26.915 0 HTR2A chr13: 46975365-56115403 1925 9140039 1 rs7333428 rs9537164 28.591 0 HTR2A chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 IMPDH2 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 IMPDH2 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 IMPDH2 chr3: 46713865-52833805 488 6119941 1 rs3935248 rs3617 54.926 0 IMPDH2 chr5: 73958245-81276023 1632 7317779 3 rs4703640 rs4703863 22.731 0 IQGAP2 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 IQGAP2 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 IQGAP2 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 IQGAP2 chr10: 28216167-33956346 1404 5740180 3 rs6481494 rs2891376 43.482 0 ITGB1 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 ITGB1 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 ITGB7 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 ITGB7 chr12: 53517820-53621711 14 103892 3 rs2280697 rs10082776 3.878 0 ITGB7 chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 ITPR1 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 ITPR1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 KIAA0090 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 KIAA0090 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 KIAA1683 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 KIAA1683 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 KIAA1683 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 LAMA4 chr6: 69745723-124631456 10981 54885734 1 rs2225803 rs932600 38.287 0 LAMA4 chr6: 93575149-115508938 4238 21933790 1 rs4707762 cnvi0021859 41.857 0 LAMA4 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 LAMA4 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 LAMA4 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 LAMA4 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 LAMA4 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 LAMA4 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 LAMA4 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 LAMA4 chr4: 182173261-187358040 1508 5184780 3 rs11930209 rs4862695 63.646 0 LRP2BP chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 LRP2BP chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 LRP2BP chr4: 125165157-188223037 11572 63057881 3 rs6854804 rs9993067 11.06 0 LRP2BP chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 LRRC59 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 LRRC59 chr6: 29877864-35562640 12719 5684777 3 rs28592582 rs3798346 61.622 0 LTA chr6: 428722-31742590 1987 31313869 3 rs1473602 rs707928 44.729 0 LTA chr6: 31289284-32512164 1746 1222881 3 rs9265170 rs28495356 24.02 0 LTA chr6: 31289284-32499014 9991 1209731 3 rs9265170 cnvi0006585 23.466 0 LTA chr6: 31281438-32354073 8034 1072636 1 cnvi0006173 rs7759813 34.729 0 LTA chr6: 31281438-31880637 8674 599200 1 cnvi0006173 rs28435656 31.216 0 LTA chr6: 31281438-31878433 8677 596996 1 cnvi0006173 rs519417 56.15 0 LTA chr6: 31281438-31795082 8770 513645 1 cnvi0006173 rs5026931 58.163 0 LTA chr6: 26430981-31878433 8001 5447453 1 rs2893848 rs519417 55.651 0 LTA chr6: 31204008-32355605 1755 1151598 1 rs7745906 rs9268472 61.163 0 LTA chr4: 415311-15136380 3262 14721070 3 rs7695712 rs2702525 10.287 0 LYAR chr4: 1224811-7063524 1270 5838714 1 rs4974574 rs6836129 27.935 0 LYAR chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 LYAR chr8: 53363937-64107847 2115 10743911 3 rs284818 rs2043525 25.971 0 LYN chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 LYN chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 LYN chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 LYN chr8: 56589428-56906068 65 316641 3 rs7460004 rs10282821 88.674 0 LYN chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 MAP4 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 MAP4 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 MAP4 chr3: 46713865-52833805 488 6119941 1 rs3935248 rs3617 54.926 0 MAP4 chr22: 19413706-51123505 7927 31709800 3 rs9618567 rs9616816 6.837 0 MAPK1 chr22: 19765182-43845708 5546 24080527 1 rs4819843 rs135044 57.345 0 MAPK1 chr22: 17394989-22573637 1104 5178649 3 rs1860945 rs12159423 32.25 0 MAPK1 chr22: 18877787-23040362 1092 4162576 3 rs2543958 rs5996349 1181.316 0 MAPK1 chr22: 21939675-22971768 397 1032094 1 rs5754217 rs9620151 562.05 0 MAPK1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 MAPT chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 MAPT chr17: 43657921-44354796 88 696876 3 rs9898857 rs2732700 28.613 0 MAPT chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 MARK4 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 MARK4 chr19: 40344648-46426076 806 6081429 1 rs12609590 rs8101540 27.283 0 MARK4 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 MARK4 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 MARK4 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 MARK4 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 MARK4 chr18: 55225777-67600991 3130 12375215 3 rs1736442 rs11151547 39.543 0 MC4R chr18: 46577218-63087976 3720 16510759 1 rs357893 rs487555 37.146 0 MC4R chr18: 58316345-58573151 29 256807 1 rs9964060 rs7233420 16.278 276344 MC4R chr6: 41773322-45545975 754 3772654 3 rs2153878 rs7764616 22.895 0 MRPL14 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 MRPL14 chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 MRPL14 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 MRPL14 chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 MRPS16 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 MRPS16 chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 MRPS16 chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 MRPS16 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 MTHFD1 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 MTHFD1 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 MTHFD1 chr14: 64926097-65063315 19 137219 1 rs2281603 rs10134770 14.377 0 MTHFD1 chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 MTNR1A chr4: 125165157-188223037 11572 63057881 3 rs6854804 rs9993067 11.06 0 MTNR1A chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 MTNR1B chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 MTNR1B chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 MTNR1B chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 MX1 chr21: 41509457-47941916 1911 6432460 3 rs741802 rs2096507 27.753 0 MX1 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 MX1 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 MX1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 MX1 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 MX1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 MX1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 MX1 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 MX1 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 MX1 chr21: 27808458-44731138 4502 16922681 1 rs150760 rs504022 45.745 0 MX1 chr21: 37312170-45589727 2506 8277558 1 rs1573303 rs4818886 41.534 0 MX1 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 MX1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 MX1 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 MX1 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 MX1 chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 MYC chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 MYC chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 MYC chr8: 84037048-138506934 11020 54469887 1 rs13265895 rs1849692 72.228 0 MYC chr6: 68563328-76635743 1594 8072416 3 rs1399225 rs9343330 47.996 0 MYO6 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 MYO6 chr6: 69745723-124631456 10981 54885734 1 rs2225803 rs932600 38.287 0 MYO6 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 MYO6 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 MYO6 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 MYO6 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 MYO6 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 MYO6 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 NANS chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 NANS chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 NANS chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 NANS chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 NCK1 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 NCK1 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 NCK1 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 NCK1 chr3: 94377411-140094984 8050 45717574 3 rs9844990 rs7618673 46.041 0 NCK1 chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 NCK1 chr14: 32903616-37374768 1191 4471153 3 rs2383302 rs17105665 31.38 0 NFKBIA chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 NFKBIA chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 NMI chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 NMI chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 NMI chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 NMI chr4: 149196991-157601193 1461 8404203 3 rs6812904 rs10030015 30.798 0 NPY2R chr4: 156087185-156213709 21 126525 1 rs10030872 rs983146 15.037 0 NPY2R chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 NPY2R chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 NPY2R chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 NPY2R chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 NPY2R chr4: 125165157-188223037 11572 63057881 3 rs6854804 rs9993067 11.06 0 NPY2R chr4: 126959315-183880263 10103 56920949 3 rs9985873 rs2714510 50.565 0 NPY2R chr4: 148566463-156666845 1395 8100383 1 rs17475359 rs6814688 54.297 0 NPY2R chr4: 155739051-165849854 1997 10110804 1 rs7691720 rs10005938 26.215 0 NPY2R chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 NUDC chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 NUDC chr1: 27161670-27475785 31 314116 3 rs11247599 rs11247613 40.308 0 NUDC chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 OPRD1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 OPRD1 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 PAFAH1B3 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 PAFAH1B3 chr19: 40344648-46426076 806 6081429 1 rs12609590 rs8101540 27.283 0 PAFAH1B3 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 PAFAH1B3 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 PAFAH1B3 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 PAFAH1B3 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 PAFAH1B3 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 PCBP1 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 PCBP1 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 PCBP1 chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 PCBP1 chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 PCBP3 chr21: 41509457-47941916 1911 6432460 3 rs741802 rs2096507 27.753 0 PCBP3 chr21: 46466674-47652185 275 1185512 1 rs4819020 rs2839160 84.642 0 PCBP3 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 PCBP3 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 PCBP3 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 PCBP3 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 PCBP3 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 PCBP3 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 PCBP3 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 PCBP3 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 PCBP3 chr21: 44744540-47642272 785 2897733 1 rs10084596 rs2280957 41.824 0 PCBP3 chr21: 47091361-47265786 27 174426 1 rs2838973 rs1009577 13.147 0 PCBP3 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 PCBP3 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 PCBP3 chr21: 46381900-48098560 448 1716661 1 rs8132265 cnvi0019195 712.68 0 PCBP3 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 PCBP3 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 PCBP3 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 PCDHA4 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 PCDHA4 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 PCDHA4 chr6: 146892943-169478886 6121 22585944 3 rs12199886 rs13219463 43.565 0 PCMT1 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 PCMT1 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 PCMT1 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 PCMT1 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 PCMT1 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 PCMT1 chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 PCMT1 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 PDCD5 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 PDCD5 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 PDCD5 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 PDCD5 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 PDCD5 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 PDE1B chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 PDE1B chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 PDE1C chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 PDE1C chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 PDE1C chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 PDE6G chr17: 79150654-81047708 15608 1897055 1 rs12103867 rs35680231 31.668 0 PDE6G chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 PGM1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 PGM1 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 PHKB chr16: 28301487-31147548 157 2846062 1 rs9939450 rs2855475 36.755 0 PHKG2 chr16: 29130999-33612830 601 4481832 3 rs12922496 rs2067108 21.218 0 PHKG2 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 PHKG2 chr16: 28642242-33612830 684 4970589 4 rs34954049 rs2067108 4.025 0 PHKG2 chr22: 19413706-51123505 7927 31709800 3 rs9618567 rs9616816 6.837 0 PICK1 chr22: 19765182-43845708 5546 24080527 1 rs4819843 rs135044 57.345 0 PICK1 chr3: 178310836-179125585 142 814750 3 rs7636991 rs13074663 6.695 0 PIK3CA chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 PIK3CA chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 PIK3CA chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 PIK3CA chr3: 161695760-196993693 7208 35297934 1 rs4575917 rs406284 54.788 0 PIK3CA chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 PIK3R1 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 PIK3R1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 PIK3R1 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 PLA2G7 chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 PLA2G7 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 PLA2G7 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 PLA2G7 chr20: 6111569-21985498 4344 15873930 3 rs6038366 rs6047798 43.161 0 PLCB1 chr11: 60589137-64068310 499 3479174 1 rs656736 rs2286614 53.467 0 PLCB3 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 PLCB3 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 PLCB3 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 PLCB3 chr11: 63907079-64027888 19 120810 1 rs7112960 rs915987 17.869 0 PLCB3 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 PLCG2 chr16: 69829875-88530172 5884 18700298 1 rs4985547 rs4782368 30.145 0 PLCG2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 PPIH chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 PPIH chr1: 42204406-46534543 635 4330138 1 rs710231 rs785512 33.167 0 PPIH chr1: 42601214-43343707 101 742494 1 rs7516178 rs11210746 136.315 0 PPIH chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 PPP2R1A chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 PPP2R1A chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 PPP2R1A chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 PPP2R1A chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 PPP2R1A chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 PRDX1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 PRDX1 chr1: 42204406-46534543 635 4330138 1 rs710231 rs785512 33.167 0 PRDX1 chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 PRKCA chr17: 63761021-67215712 732 3454692 1 cnvi0008594 rs12941264 55.59 0 PRKCA chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 PRKCA chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 PRKCA chr17: 59314257-66170047 1135 6855791 1 rs758467 rs4558468 71.379 0 PRKCA chr17: 61016209-66240093 890 5223885 1 rs1588368 rs11658645 37.309 0 PRKCA chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 PRLHR chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 PRLHR chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 PRLHR chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 PRLHR chr10: 99160152-130771382 6972 31611231 3 rs1048442 rs12258650 21.306 0 PRLHR chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 PRMT1 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 PRMT1 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 PRMT1 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 PRMT1 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 PRMT1 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 PRMT1 chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 PRPSAP1 chr17: 74204592-79532654 1324 5328063 1 rs4505373 rs3934711 38.57 0 PRPSAP1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 PRPSAP1 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 PRPSAP1 chr17: 67081830-78829375 2912 11747546 1 rs2302134 rs12943041 31.498 0 PRPSAP1 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 PSAT1 chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 PSAT1 chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 PSAT1 chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 PSAT1 chr9: 77857783-82347458 1181 4489676 1 rs12000663 rs4387054 36.701 0 PSAT1 chr9: 81057409-81234650 49 177242 3 rs4498630 rs11137772 24.969 112400 PSAT1 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 PSEN1 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 PSEN1 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 PSEN1 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 PSMC1 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 PSMC1 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 PSMC1 chr2: 211013993-242051777 6871 31037785 3 rs4673499 rs2074824 40.702 0 PSMD1 chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 PSMD1 chr2: 231913056-232047561 18 134506 1 rs3731783 rs7585622 16.163 0 PSMD1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 PSMD1 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 PSMD1 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 PSMD1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 PSMD11 chr11: 198510-5875867 1467 5677358 3 rs3802985 rs2045046 49.035 0 PSMD13 chr11: 219089-1139111 206 920023 1 rs511744 rs11245979 38.286 0 PSMD13 chr3: 60053331-70925955 2977 10872625 3 rs2630173 rs9856621 30.024 0 PSMD6 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 PSMD6 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 PSMD6 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 PSMD6 chr14: 22513116-32242747 1997 9729632 1 rs4982546 rs17098165 31.673 0 PSME1 chr12: 120396295-120709064 35 312770 1 rs4767865 rs3999561 29.821 0 PXN chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 PXN chr12: 112610714-133708729 5366 21098016 3 rs11066188 rs11147249 695.45 0 PXN chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 PYGL chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 PYGL chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 PYGM chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 PYGM chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 PYGM chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 QRICH2 chr17: 74204592-79532654 1324 5328063 1 rs4505373 rs3934711 38.57 0 QRICH2 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 QRICH2 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 QRICH2 chr17: 67081830-78829375 2912 11747546 1 rs2302134 rs12943041 31.498 0 QRICH2 chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 RALA chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 RALA chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 RALA chr22: 19413706-51123505 7927 31709800 3 rs9618567 rs9616816 6.837 0 RANBP1 chr22: 19765182-43845708 5546 24080527 1 rs4819843 rs135044 57.345 0 RANBP1 chr22: 18877787-21462353 510 2584567 1 rs2543958 rs140392 1090.228 0 RANBP1 chr22: 17394989-22573637 1104 5178649 3 rs1860945 rs12159423 32.25 0 RANBP1 chr22: 18877787-23040362 1092 4162576 3 rs2543958 rs5996349 1181.316 0 RANBP1 chr22: 18877787-21462353 512 2584567 1 rs2543958 rs140392 360.702 0 RANBP1 chr22: 19025381-20228542 296 1203162 1 rs6623 rs701428 38.244 0 RANBP1 chr22: 19735854-20155192 142 419339 1 rs6518580 rs373747 36.567 0 RANBP1 chr22: 19613784-21462353 380 1848570 3 rs5993743 rs140392 153.49 0 RANBP1 chr22: 18877787-21461274 612 2583488 3 rs2543958 rs140391 1388.235 0 RANBP1 chr13: 60985192-114224496 12638 53239305 1 rs1341840 rs4907646 40.079 0 RAP2A chr13: 34752890-109100024 15589 74347135 1 rs2321822 rs7332707 33.721 0 RAP2A chr13: 41369790-112329394 15030 70959605 3 rs1536807 rs9588495 26.915 0 RAP2A chr13: 63692683-113075599 10941 49382917 1 rs9592243 rs9550080 27.124 0 RAP2A chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 RCC1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 RCC1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 RCC2 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 RCC2 chr4: 415311-15136380 3262 14721070 3 rs7695712 rs2702525 10.287 0 RGS12 chr4: 1224811-7063524 1270 5838714 1 rs4974574 rs6836129 27.935 0 RGS12 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 RGS12 chr1: 186642429-197195650 1628 10553222 4 rs2206593 rs4915406 24.676 0 RGS2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 RGS2 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 RGS2 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 RGS2 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 RGS2 chr1: 188735336-196495566 1363 7760231 1 rs10754227 rs6693594 68.665 0 RGS2 chr1: 188802542-196412070 1346 7609529 1 rs10158341 rs12075206 61.486 0 RGS2 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 RGS2 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 RHOA chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 RHOA chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 RHOA chr3: 46713865-52833805 488 6119941 1 rs3935248 rs3617 54.926 0 RHOA chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 RIF1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 RIF1 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 RIF1 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 RIF1 chr2: 152251363-152423605 27 172243 1 rs10173597 rs3732311 11.735 0 RIF1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 RPA2 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 RPA2 chr11: 198510-5875867 1467 5677358 3 rs3802985 rs2045046 49.035 0 RPLP2 chr11: 766479-870446 11 103968 1 rs7937869 rs6682 15.548 0 RPLP2 chr11: 589246-2866248 476 2277003 1 rs7116322 rs2237899 43.461 0 RPLP2 chr11: 549119-1323564 100 774446 1 rs4963136 rs5743899 50.097 0 RPLP2 chr11: 392079-3226221 734 2834143 1 rs6598025 rs10833462 79.883 0 RPLP2 chr11: 356090-2201163 310 1845074 1 rs12049834 rs6578993 40.709 0 RPLP2 chr11: 219089-1139111 206 920023 1 rs511744 rs11245979 38.286 0 RPLP2 chr20: 34817545-44483225 1946 9665681 1 rs17093449 rs6130947 4536.622 0 RPN2 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 RPS14 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 RPS14 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 RPS14 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 RPS14 chr11: 198510-5875867 1467 5677358 3 rs3802985 rs2045046 49.035 0 RRM1 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 RUVBL2 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 RUVBL2 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 RUVBL2 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 RUVBL2 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 RUVBL2 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 RUVBL2 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 RYR1 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 RYR1 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 RYR1 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 RYR1 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 RYR1 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 RYR1 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 RYR2 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 RYR2 chr1: 237310139-239159611 464 1849473 1 rs2490371 rs1915278 47.032 0 RYR2 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 RYR2 chr1: 237584925-237904870 86 319946 1 rs4593814 rs10925504 31.95 0 RYR2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 S100A6 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 S100A6 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 S100A6 chr13: 19496434-50144613 7295 30648180 3 rs1838114 rs11148151 43.395 0 SACS chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 SARS chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 SARS chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 SARS chr2: 119935802-128867841 1515 8932040 3 rs935361 rs6747421 14.116 0 SCTR chr2: 116260745-130688292 2685 14427548 3 rs1868327 rs10928943 1170.496 0 SCTR chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 SCTR chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 SCTR chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 SCTR chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 SCTR chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 SDC3 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 SDC3 chr1: 164144117-180071987 3186 15927871 3 rs12037444 rs6425606 30.846 0 SELE chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 SELE chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 SELE chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 SELE chr6: 428722-31742590 1987 31313869 3 rs1473602 rs707928 44.729 0 SERPINB9 chr6: 2681610-31453618 81 28772009 1 rs1131896 rs9267212 428.052 0 SERPINB9 chr6: 1165092-29899147 56 28734056 0 rs3128864 rs2394704 57.657 0 SERPINB9 chr6: 1171596-29892436 39 28720841 1 rs3128994 rs9259806 33.185 0 SERPINB9 chr6: 2681610-31453113 80 28771504 3 rs1131896 rs2904600 359.691 0 SERPINB9 chr6: 1171596-29899147 47 28727552 0 rs3128994 rs2394704 61.991 0 SERPINB9 chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 40.382 0 SERPINB9 chr6: 2681610-31453618 81 28772009 3 rs1131896 rs9267212 390.234 0 SERPINB9 chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 34.598 0 SERPINB9 chr6: 1171596-29892436 39 28720841 1 rs3128994 rs9259806 31.699 0 SERPINB9 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 SET chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 SET chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 SET chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 SET chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 SETD4 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 SETD4 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 SETD4 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 SETD4 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 SETD4 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 SETD4 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 SETD4 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 SETD4 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 SETD4 chr21: 27808458-44731138 4502 16922681 1 rs150760 rs504022 45.745 0 SETD4 chr21: 37312170-45589727 2506 8277558 1 rs1573303 rs4818886 41.534 0 SETD4 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 SETD4 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 SETD4 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 SETD4 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 SETD4 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 SF3B14 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 SHANK1 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 SHANK1 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 SHANK1 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 SHANK1 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 SHANK1 chr17: 7031638-7592780 100 561143 3 rs2062737 rs2287497 12.667 0 SHBG chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 SIAH1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 SLC2A1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 SLC2A1 chr1: 42204406-46534543 635 4330138 1 rs710231 rs785512 33.167 0 SLC2A1 chr1: 43380982-44438396 167 1057415 1 rs841837 rs783308 180.439 0 SLC2A1 chr5: 1132216-9177932 2386 8045717 3 rs4594899 rs3777281 13.79 0 SLC6A3 chr5: 177264-1850563 577 1673300 1 rs6889904 rs10512644 26.987 0 SLC6A3 chr4: 88117272-90765280 562 2648009 3 rs6531956 rs1372522 17.723 0 SNCA chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 SNCA chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 SNCA chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 SNCA chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 SNCA chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 SNCA chr4: 31619950-97811299 11610 66191350 1 rs6811437 rs12644209 44.41 0 SNCA chr20: 6111569-21985498 4344 15873930 3 rs6038366 rs6047798 43.161 0 SNRPB2 chr18: 63017137-71284888 2142 8267752 1 rs12966197 rs1107827 34.629 0 SOCS6 chr18: 63733025-69401985 1543 5668961 1 rs2715290 rs993816 45.936 0 SOCS6 chr18: 67544717-69365932 428 1821216 3 rs1788244 rs1394981 461.753 0 SOCS6 chr18: 62041997-76047493 3846 14005497 1 rs1421538 rs8085865 33.212 0 SOCS6 chr17: 35814383-36784639 134 970257 1 rs853231 rs7220099 43.224 0 SOCS7 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 SOCS7 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 SOCS7 chr15: 40561890-65059651 4763 24497762 1 rs6492939 rs1008917 60.034 0 SORD chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 SORD chr20: 34817545-44483225 1946 9665681 1 rs17093449 rs6130947 4536.622 0 SRC chr12: 11740163-33217793 5315 21477631 3 rs10491981 rs12424662 69.717 0 STRAP chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 STRAP chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 STX12 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 STX12 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 SYK chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 SYK chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 SYK chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 SYK chr5: 73958245-81276023 1632 7317779 3 rs4703640 rs4703863 22.731 0 TBCA chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 TBCA chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 TBCA chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 TBCA chr5: 76450190-79622472 726 3172283 1 rs6864250 rs2405378 35.823 0 TBCA chr19: 3053574-18061509 2612 15007936 3 rs7938 rs7250332 73.169 0 TBXA2R chr19: 1961474-14570703 2131 12609230 1 rs2041120 rs12974686 29.276 0 TBXA2R chr19: 384644-4514135 854 4129492 1 rs12151104 rs4807598 56.902 0 TBXA2R chr6: 146892943-169478886 6121 22585944 3 rs12199886 rs13219463 43.565 0 TCP1 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 TCP1 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 TCP1 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 TCP1 chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 TCP1 chr6: 29877864-35562640 12719 5684777 3 rs28592582 rs3798346 61.622 0 TEAD3 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 TEAD3 chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 TEAD3 chr10: 52338100-60396065 1797 8057966 4 rs10508930 rs920259 44.979 0 TFAM chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 TFAM chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 TFAM chr20: 34817545-44483225 1946 9665681 1 rs17093449 rs6130947 4536.622 0 TGM2 chr15: 24991944-36734986 2650 11743043 3 rs11161135 rs2444757 14.503 0 TJP1 chr15: 20161372-30439396 1944 10278025 4 rs6599770 cnvi0020349 10.79 0 TJP1 chr15: 27740007-30366247 464 2626241 1 rs6497213 rs10152753 44.251 0 TJP1 chr15: 20058438-32544679 2394 12486242 3 rs12591240 cnvi0018163 296.82 0 TJP1 chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 TK1 chr17: 74204592-79532654 1324 5328063 1 rs4505373 rs3934711 38.57 0 TK1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 TK1 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 TK1 chr17: 67081830-78829375 2912 11747546 1 rs2302134 rs12943041 31.498 0 TK1 chr4: 36130920-40415109 1046 4284190 3 rs13142416 rs278933 15.979 0 TLR10 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 TLR10 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 TLR10 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 TLR10 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 TLR10 chr4: 31619950-97811299 11610 66191350 1 rs6811437 rs12644209 44.41 0 TLR10 chr3: 160836006-176261513 2782 15425508 4 rs1599389 rs1377820 17.004 0 TNIK chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 TNIK chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 TNIK chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 TNIK chr3: 161695760-196993693 7208 35297934 1 rs4575917 rs406284 54.788 0 TNIK chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 TNIK chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 TPI1 chr9: 137718113-139841512 539 2123400 4 rs4842173 rs884113 1.053 0 TRAF2 chr9: 138961722-140376668 138 1414947 1 rs11103306 rs10116708 35.913 0 TRAF2 chr9: 138873600-140938183 302 2064584 1 cnvi0002612 rs3750506 26.611 0 TRAF2 chr9: 139492789-140212642 109 719854 1 rs28485548 rs13295516 79.502 0 TRAF2 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 TRMT112 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 TRMT112 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 TRMT112 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 TUBA1A chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 TUBA1A chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 TUBA1B chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 TUBA1B chr6: 19044000-31286381 6774 12242382 1 rs6922929 rs9265057 31.6 0 TUBB chr6: 29877864-35562640 12719 5684777 3 rs28592582 rs3798346 61.622 0 TUBB chr6: 428722-31742590 1987 31313869 3 rs1473602 rs707928 44.729 0 TUBB chr6: 2681610-31453618 81 28772009 1 rs1131896 rs9267212 428.052 0 TUBB chr6: 2681610-31453113 80 28771504 3 rs1131896 rs2904600 359.691 0 TUBB chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 40.382 0 TUBB chr6: 3764851-31298743 7861 27533893 3 rs28880026 rs28752863 40.215 0 TUBB chr6: 3772684-31298743 7858 27526060 3 rs12661707 rs28752863 27.127 0 TUBB chr6: 11677538-31289284 4992 19611747 1 rs2022016 rs9265170 68.97 0 TUBB chr6: 19812444-31286381 6951 11473938 1 rs16882740 rs9265057 32.473 0 TUBB chr6: 29864203-31294687 11756 1430485 3 rs9259437 rs28752836 6.497 0 TUBB chr6: 26430981-31878433 8001 5447453 1 rs2893848 rs519417 55.651 0 TUBB chr6: 2681610-31453618 81 28772009 3 rs1131896 rs9267212 390.234 0 TUBB chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 34.598 0 TUBB chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 TUBG1 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 TUBG1 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 TXN chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 TXN chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 TXN chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 TXN chr18: 112535-3081210 758 2968676 1 rs9284390 rs7244954 2389.768 0 TYMS chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 UBQLN4 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 UBQLN4 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 UBQLN4 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 UCHL1 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 UCHL1 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 UCHL1 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 UCHL1 chr4: 31619950-97811299 11610 66191350 1 rs6811437 rs12644209 44.41 0 UCHL1 chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 VHL chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 VHL chr3: 9972493-10372840 66 400348 1 rs279545 rs26310 30.958 0 VHL chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 VIPR1 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 VIPR1 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 VIPR1 chr2: 3994639-20951332 3904 16956694 3 rs4850016 rs619562 20.912 0 YWHAQ chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 ZAP70 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 ZAP70 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 ZAP70 chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 ZAP70

TABLE 3 Distance From Chr: Start-Stop (hg19) NumSNP Length State, CN StartSNP EndSNP Confidence Gene mGluR Gene chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 ABI3 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 ABI3 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 ACAT1 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 ACAT1 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 ACAT1 chr6: 146892943-169478886 6121 22585944 3 rs12199886 rs13219463 43.565 0 ACAT2 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 ACAT2 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 ACAT2 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 ACAT2 chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 ACAT2 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 ACCN1 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 ACCN2 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 ACCN2 chr2: 89910-272926 44 183017 3 rs300789 rs12714402 129.774 0 ACP1 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 ACTA1 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 ACTA1 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 ACTA1 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 ACTA1 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 ACTN2 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 ACTN2 chr1: 236771404-236893599 39 122196 1 rs12408801 rs819639 19.928 0 ACTN2 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 ACTN2 chr2: 54984424-67416189 2413 12431766 3 rs980644 rs12473913 14.927 0 ACTR2 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 ACTR2 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 ACTR2 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 ACTR2 chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 ACTR2 chr20: 39998520-43592248 934 3593729 1 rs6072353 rs2868218 29.278 0 ADA chr20: 34817545-44483225 1946 9665681 1 rs17093449 rs6130947 4536.622 0 ADA chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 ADCY1 chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 ADCY1 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 ADCY1 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 ADCY1 chr7: 44112529-45698253 270 1585725 1 rs7778745 rs2960288 51.042 0 ADCY1 chr3: 116881714-132034199 2802 15152486 3 rs7649284 rs3844501 21.439 0 ADCY5 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 ADCY5 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 ADCY5 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 ADCY5 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 ADCY5 chr3: 94377411-140094984 8050 45717574 3 rs9844990 rs7618673 46.041 0 ADCY5 chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 ADCY5 chr8: 129840739-132546350 628 2705612 3 rs2395855 rs7010302 6.721 0 ADCY8 chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 ADCY8 chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 ADCY8 chr8: 130849731-132416893 371 1567163 1 rs298622 rs11774542 59.301 0 ADCY8 chr8: 84037048-138506934 11020 54469887 1 rs13265895 rs1849692 72.228 0 ADCY8 chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 ADCY8 chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 ADCYAP1R1 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 ADCYAP1R1 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 ADCYAP1R1 chr4: 1224811-7063524 1270 5838714 1 rs4974574 rs6836129 27.935 0 ADD1 chr4: 415311-15136380 3262 14721070 3 rs7695712 rs2702525 10.287 0 ADD1 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 ADD1 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 ADD2 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 ADD2 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 ADD2 chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 ADD2 chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 ADD3 chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 ADD3 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 ADD3 chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 ADD3 chr10: 99160152-130771382 6972 31611231 3 rs1048442 rs12258650 21.306 0 ADD3 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 ADORA1 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 ADORA1 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 ADORA1 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 ADORA1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 ADORA1 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 ADORA1 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 ADRA1B chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 ADRA1B chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 ADRA1B chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 ADRA1B chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 ADRA2A chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 ADRA2A chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 ADRA2A chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 ADRA2A chr10: 99160152-130771382 6972 31611231 3 rs1048442 rs12258650 21.306 0 ADRA2A chr4: 1224811-7063524 1270 5838714 1 rs4974574 rs6836129 27.935 0 ADRA2C chr4: 415311-15136380 3262 14721070 3 rs7695712 rs2702525 10.287 0 ADRA2C chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 ADRA2C chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 ADRB2 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 ADRB2 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 ADRB2 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 ADRB2 chr11: 65226187-67799926 252 2573740 1 rs1626021 rs2075626 54.033 0 ADRBK1 chr11: 66842469-67046501 18 204033 1 rs11227678 rs12274774 20.038 0 ADRBK1 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 ADRBK1 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 ADRBK1 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 ADRBK1 chr4: 415311-15136380 3262 14721070 3 rs7695712 rs2702525 10.287 0 AFAP1 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 AFAP1 chr3: 147200492-151900719 955 4700228 3 rs9876193 rs325713 20.467 0 AGTR1 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 AGTR1 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 AGTR1 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 AGTR1 chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 AGTR1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 AHCYL1 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 AHCYL1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 AHCYL1 chr6: 146892943-169478886 6121 22585944 3 rs12199886 rs13219463 43.565 0 AKAP12 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 AKAP12 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 AKAP12 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 AKAP12 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 AKAP12 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 AKAP12 chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 AKAP12 chr15: 72136872-102040672 6413 29903801 3 rs4777466 rs7179692 18.158 0 AKAP13 chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 AKAP13 chr15: 73186518-94501564 4223 21315047 1 rs1947219 rs4344687 34.841 0 AKAP13 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 AKAP5 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 AKAP5 chr14: 64935411-65222549 48 287139 3 rs2230491 rs7154518 18.8 0 AKAP5 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 AKAP5 chr14: 64926097-65063315 19 137219 1 rs2281603 rs10134770 14.377 0 AKAP5 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 AKAP9 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 AKAP9 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 AKAP9 chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 AKAP9 chr14: 104506888-105268228 119 761341 1 rs2273842 rs4983387 28.111 0 AKT1 chr14: 102003864-105246686 423 3242823 1 rs1190712 rs2494738 38.435 0 AKT1 chr14: 104581072-105779305 166 1198234 1 rs1557012 rs11847295 23.591 0 AKT1 chr14: 104004311-106009572 243 2005262 4 rs8014069 rs10134526 0.055 0 AKT1 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 AKT1 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 AKT1 chr16: 28301487-31147548 157 2846062 1 rs9939450 rs2855475 36.755 0 ALDOA chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 ALDOA chr16: 29130999-33612830 601 4481832 3 rs12922496 rs2067108 21.218 0 ALDOA chr16: 28642242-33612830 684 4970589 4 rs34954049 rs2067108 4.025 0 ALDOA chr4: 108454525-114225831 1057 5771307 3 rs1877863 rs29311 22.746 0 ANK2 chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 ANK2 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 ANK2 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 ANK2 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 ANK2 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 ANK2 chr19: 1961474-14570703 2131 12609230 1 rs2041120 rs12974686 29.276 0 ANKRD24 chr19: 3053574-18061509 2612 15007936 3 rs7938 rs7250332 73.169 0 ANKRD24 chr19: 384644-4514135 854 4129492 1 rs12151104 rs4807598 56.902 0 ANKRD24 chr15: 40561890-65059651 4763 24497762 1 rs6492939 rs1008917 60.034 0 ANXA2 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 ANXA2 chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 ANXA2 chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 ANXA2 chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 ANXA2 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 ANXA6 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 ANXA6 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 ANXA6 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 ANXA6 chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 ANXA7 chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 ANXA7 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 ANXA7 chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 ANXA7 chr11: 129866653-129987100 16 120448 0 rs7124927 rs12281267 17.645 0 APLP2 chr11: 114191016-134258416 5073 20067401 3 rs2847476 rs893951 4.233 0 APLP2 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 APLP2 chr11: 127340512-130283749 656 2943238 1 rs1358557 rs10894195 48.071 0 APLP2 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 APLP2 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 APP chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 APP chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 APP chr21: 25452702-29545417 1017 4092716 3 rs2019006 rs2831606 41.533 0 APP chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 APP chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 APP chr21: 14569317-28194874 3308 13625558 3 rs1772304 rs7278460 1086.833 0 APP chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 APP chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 APP chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 APP chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 APP chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 APP chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 APP chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 APP chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 APTX chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 APTX chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 APTX chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 AQP1 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 AQP1 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 AQP1 chr1: 228216997-228500627 33 283631 1 rs708122 rs2087121 53.416 0 ARF1 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 ARF1 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 ARF1 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 ARF1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 ARF1 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 ARF1 chr12: 49128261-49478812 46 350552 1 rs6580694 rs6580699 32.9 0 ARF3 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 ARF3 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 ARF3 chr11: 38685169-55210647 1957 16525479 3 rs1026834 rs11229683 17.562 0 ARHGAP1 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 ARHGAP1 chr11: 46297631-46699124 35 401494 1 rs10437653 rs8914 25.596 0 ARHGAP1 chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 ARHGAP24 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 ARHGAP24 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 ARHGAP24 chr4: 31619950-97811299 11610 66191350 1 rs6811437 rs12644209 44.41 0 ARHGAP24 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 ARHGAP24 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 ARHGAP24 chr19: 40344648-46426076 806 6081429 1 rs12609590 rs8101540 27.283 0 ARHGEF1 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 ARHGEF1 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 ARHGEF1 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 ARHGEF1 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 ARHGEF1 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 ARHGEF1 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 ARHGEF1 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 ARL15 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 ARL15 chr5: 52884614-53418318 145 533705 1 rs524289 rs9292039 31.471 0 ARL15 chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 ARL3 chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 ARL3 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 ARL3 chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 ARL3 chr10: 99160152-130771382 6972 31611231 3 rs1048442 rs12258650 21.306 0 ARL3 chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 ARL8B chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 ARL8B chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 ARRB1 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 ARRB1 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 ARRB1 chr11: 589246-2866248 476 2277003 1 rs7116322 rs2237899 43.461 0 ASCL2 chr11: 198510-5875867 1467 5677358 3 rs3802985 rs2045046 49.035 0 ASCL2 chr11: 392079-3226221 734 2834143 1 rs6598025 rs10833462 79.883 0 ASCL2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 ATF3 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 ATF3 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 ATF3 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 ATF3 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 ATF3 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 ATF3 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 ATN1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 ATP1B1 chr1: 164144117-180071987 3186 15927871 3 rs12037444 rs6425606 30.846 0 ATP1B1 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 ATP1B1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 ATP1B1 chr12: 89916811-91124916 172 1208106 3 rs2230283 rs1948839 7.928 0 ATP2B1 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 ATP2B1 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 ATP2B1 chr12: 84152210-113464649 5560 29312440 1 rs10862748 rs16942470 28.181 0 ATP2B1 chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 ATP2B2 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 ATP2B2 chr3: 9972493-10372840 66 400348 1 rs279545 rs26310 30.958 0 ATP2B2 chr6: 428722-31742590 1987 31313869 3 rs1473602 rs707928 44.729 0 ATXN1 chr6: 2681610-31453618 81 28772009 1 rs1131896 rs9267212 428.052 0 ATXN1 chr6: 3764851-31298743 7861 27533893 3 rs28880026 rs28752863 40.215 0 ATXN1 chr6: 3772684-31298743 7858 27526060 3 rs12661707 rs28752863 27.127 0 ATXN1 chr6: 2681610-31453113 80 28771504 3 rs1131896 rs2904600 359.691 0 ATXN1 chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 40.382 0 ATXN1 chr6: 1165092-29899147 56 28734056 0 rs3128864 rs2394704 57.657 0 ATXN1 chr6: 1171596-29892436 39 28720841 1 rs3128994 rs9259806 33.185 0 ATXN1 chr6: 11677538-31289284 4992 19611747 1 rs2022016 rs9265170 68.97 0 ATXN1 chr6: 1171596-29899147 47 28727552 0 rs3128994 rs2394704 61.991 0 ATXN1 chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 34.598 0 ATXN1 chr6: 2681610-31453618 81 28772009 3 rs1131896 rs9267212 390.234 0 ATXN1 chr6: 1171596-29892436 39 28720841 1 rs3128994 rs9259806 31.699 0 ATXN1 chr14: 92414380-101757695 2557 9343316 3 rs3814835 rs4906092 19.826 0 ATXN3 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 ATXN3 chr14: 92421275-92600798 34 179524 1 rs2498828 rs2295726 16.381 0 ATXN3 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 ATXN3 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 ATXN3 chr3: 60053331-70925955 2977 10872625 3 rs2630173 rs9856621 30.024 0 ATXN7 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 ATXN7 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 ATXN7 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 ATXN7 chr17: 42223914-42423665 22 199752 1 rs12603404 rs3785817 49.315 0 ATXN7L3 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 ATXN7L3 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 ATXN7L3 chr12: 62261443-72745898 2376 10484456 3 rs3759288 rs2044305 73.366 0 AVPR1A chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 AVPR1A chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 AVPR1A chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 B4GALT1 chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 B4GALT1 chr9: 33141752-33260632 23 118881 3 rs2770807 rs706121 25.92 0 B4GALT1 chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 B4GALT1 chr4: 102357934-102470700 10 112767 1 rs2471683 rs10022442 38.269 0 BANK1 chr4: 101274858-103233207 334 1958350 3 rs13130455 rs6822371 16.146 0 BANK1 chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 BANK1 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 BANK1 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 BANK1 chr4: 102252696-102504356 22 251661 3 rs1348161 rs2723048 4.732 0 BANK1 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 BANK1 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 BANK1 chr16: 74647795-75306402 118 658608 3 rs4887779 rs999675 7.499 0 BCAR1 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 BCAR1 chr16: 69829875-88530172 5884 18700298 1 rs4985547 rs4782368 30.145 0 BCAR1 chr18: 55225777-67600991 3130 12375215 3 rs1736442 rs11151547 39.543 0 BCL2 chr18: 46577218-63087976 3720 16510759 1 rs357893 rs487555 37.146 0 BCL2 chr14: 92414380-101757695 2557 9343316 3 rs3814835 rs4906092 19.826 0 BDKRB1 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 BDKRB1 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 BDKRB1 chr14: 92414380-101757695 2557 9343316 3 rs3814835 rs4906092 19.826 0 BDKRB2 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 BDKRB2 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 BDKRB2 chr10: 22570391-22671116 7 100726 1 rs7913154 rs1170548 16.777 0 BMI1 chr10: 22509765-22671116 16 161352 1 rs4539216 rs1170548 17.583 0 BMI1 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 BMI1 chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 BMPR2 chr2: 203165534-203927551 67 762018 4 rs6753156 rs7573079 4.268 0 BMPR2 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 BMPR2 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 BMPR2 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 BMPR2 chr2: 185221268-213136747 4656 27915480 1 rs17501385 rs2135161 31.832 0 BMPR2 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 BOC chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 BOC chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 BOC chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 BOC chr3: 94377411-140094984 8050 45717574 3 rs9844990 rs7618673 46.041 0 BOC chr3: 95055435-114675646 3559 19620212 1 rs2871719 rs16823416 41.186 0 BOC chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 BOC chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 BPGM chr7: 117831743-152070158 6055 34238416 3 rs3808178 rs6966258 7.28 0 BPGM chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 BPGM chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 BPGM chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 BPGM chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 BRCA1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 BRCA1 chr13: 19496434-50144613 7295 30648180 3 rs1838114 rs11148151 43.395 0 BRCA2 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 BRD7 chr8: 14962494-40636979 6254 25674486 3 rs1026349 rs4403392 35.815 0 BRF2 chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 BRF2 chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 BRF2 chr11: 65226187-67799926 252 2573740 1 rs1626021 rs2075626 54.033 0 BRMS1 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 BRMS1 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 BRMS1 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 BRMS1 chr19: 1961474-14570703 2131 12609230 1 rs2041120 rs12974686 29.276 0 BTBD2 chr19: 1505874-2123516 98 617643 1 rs197198 rs2072304 26.337 0 BTBD2 chr19: 266034-2771641 432 2505608 4 rs2312724 rs741103 15.34 0 BTBD2 chr19: 1572369-3354956 351 1782588 1 rs10415156 rs4807451 45.225 0 BTBD2 chr19: 384644-4514135 854 4129492 1 rs12151104 rs4807598 56.902 0 BTBD2 chr19: 1920342-2050823 26 130482 3 rs4807169 rs3746101 85.52 0 BTBD2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 BTG2 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 BTG2 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 BTG2 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 BTG2 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 BTG2 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 BTG2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 C1orf116 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 C1orf116 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 C1orf116 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 C1orf116 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 C1orf116 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 C1orf116 chr20: 50459530-62198348 3263 11738819 3 rs6063722 rs438363 11.693 0 C20orf20 chr20: 61158952-62230974 254 1072023 1 rs11906462 rs432717 39.681 0 C20orf20 chr20: 61008620-62751454 409 1742835 1 rs2427340 rs13039817 86.487 0 C20orf20 chr20: 34817545-44483225 1946 9665681 1 rs17093449 rs6130947 4536.622 0 C20orf24 chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 C4orf17 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 C4orf17 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 C4orf17 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 C4orf17 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 C4orf17 chr5: 175559839-175687091 11 127253 3 rs7443800 rs7726699 10.109 0 C5orf25 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 C5orf25 chr5: 175559839-175687091 11 127253 3 rs7443800 rs7726699 28.516 0 C5orf25 chr5: 175559839-175687091 11 127253 3 rs7443800 rs7726699 14.514 0 C5orf25 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 C5orf25 chr5: 176010125-180058963 954 4048839 1 rs936912 rs2290983 30.904 0 C5orf25 chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 C7orf25 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 C7orf25 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 C7orf25 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 C9orf25 chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 C9orf25 chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 C9orf25 chr8: 53363937-64107847 2115 10743911 3 rs284818 rs2043525 25.971 0 CA8 chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 CA8 chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 CA8 chr8: 60654261-60775727 18 121467 1 rs1949102 rs7822560 11.681 325696 CA8 chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 CA8 chr22: 19765182-43845708 5546 24080527 1 rs4819843 rs135044 57.345 0 CABIN1 chr22: 19413706-51123505 7927 31709800 3 rs9618567 rs9616816 6.837 0 CABIN1 chr22: 24241594-24622648 39 381055 1 rs17004049 rs2275984 23.991 0 CABIN1 chr22: 23925335-25958952 515 2033618 3 rs12627824 rs2205971 279.291 0 CABIN1 chr22: 22351365-25906803 1041 3555439 3 rs5756388 rs476240 238.835 0 CABIN1 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 CABP1 chr12: 112610714-133708729 5366 21098016 3 rs11066188 rs11147249 695.45 0 CABP1 chr9: 138873600-140938183 302 2064584 1 cnvi0002612 rs3750506 26.611 0 CACNA1B chr12: 1816613-2097716 81 281104 3 rs11061937 rs4141130 0.38 0 CACNA1C chr12: 2268143-2408194 27 140052 3 rs11062134 rs4298967 15.754 0 CACNA1C chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 CACYBP chr1: 164144117-180071987 3186 15927871 3 rs12037444 rs6425606 30.846 0 CACYBP chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 CACYBP chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 CACYBP chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 CACYBP chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 CALB2 chr16: 69829875-88530172 5884 18700298 1 rs4985547 rs4782368 30.145 0 CALB2 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 CALCR chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 CALCR chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 CALCR chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 CALCR chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 CALD1 chr7: 117831743-152070158 6055 34238416 3 rs3808178 rs6966258 7.28 0 CALD1 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 CALD1 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 CALD1 chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 CALD1 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 CALM1 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 CALM1 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 CALM1 chr2: 42287306-50902931 2298 8615626 3 rs988958 rs2194390 44.151 0 CALM2 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 CALM2 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 CALM2 chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 CALM2 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 CALM3 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 CALM3 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 CALM3 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 CALM3 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 CALM3 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 CALM3 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 CALM3 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 CALM3 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 CALM3 chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 CAMK1 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 CAMK1 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 CAMK2A chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 CAMK2A chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 CAMK2A chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 CAMK2A chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 CAMK2B chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 CAMK2B chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 CAMK2B chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 CAMK2B chr7: 44112529-45698253 270 1585725 1 rs7778745 rs2960288 51.042 0 CAMK2B chr10: 75478159-75601688 10 123530 1 rs2894040 rs2254266 20.578 0 CAMK2G chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 CAMK2G chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 CAMK2G chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 CAMK2G chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 CAMK2G chr5: 106749690-117695003 2459 10945314 3 rs6868410 rs6882527 55.105 0 CAMK4 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 CAMK4 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 CAMK4 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 CAMK4 chr5: 108284342-111242002 627 2957661 1 rs3797817 rs17133870 44.164 0 CAMK4 chr17: 3781764-3882309 34 100546 1 rs9914305 rs17763551 42.821 0 CAMKK1 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 CAMKK2 chr12: 112610714-133708729 5366 21098016 3 rs11066188 rs11147249 695.45 0 CAMKK2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 CAPN2 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 CAPN2 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 CAPN2 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 CAPN2 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 CAPN2 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 CAPN2 chr4: 182173261-187358040 1508 5184780 3 rs11930209 rs4862695 63.646 0 CASP3 chr4: 125165157-188223037 11572 63057881 3 rs6854804 rs9993067 11.06 0 CASP3 chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 CASP3 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 CASP3 chr4: 108454525-114225831 1057 5771307 3 rs1877863 rs29311 22.746 0 CASP6 chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 CASP6 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 CASP6 chr4: 110561106-110741290 35 180185 1 rs6533444 rs4610335 15.769 0 CASP6 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 CASP6 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 CASP6 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 CASP6 chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 CASP7 chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 CASP7 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 CASP7 chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 CASP7 chr10: 99160152-130771382 6972 31611231 3 rs1048442 rs12258650 21.306 0 CASP7 chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 CASP8 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 CASP8 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 CASP8 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 CASP8 chr2: 185221268-213136747 4656 27915480 1 rs17501385 rs2135161 31.832 0 CASP8 chr2: 201988238-202111380 11 123143 1 rs7583529 rs3769825 18.612 0 CASP8 chr3: 116881714-132034199 2802 15152486 3 rs7649284 rs3844501 21.439 0 CASR chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 CASR chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 CASR chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 CASR chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 CASR chr3: 94377411-140094984 8050 45717574 3 rs9844990 rs7618673 46.041 0 CASR chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 CASR chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 CAV1 chr7: 112666609-125975251 1866 13308643 4 rs6957202 rs496 3.945 0 CAV1 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 CAV1 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 CAV1 chr7: 115525876-115956129 68 430254 1 rs6948855 rs12667497 28.379 0 CAV1 chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 CAV1 chr11: 114191016-134258416 5073 20067401 3 rs2847476 rs893951 4.233 0 CBL chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 CBL chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 CBL chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 CBX1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 CBX1 chr19: 54743217-58326001 842 3582785 3 rs17239607 rs2303817 41.312 0 CCDC106 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 CCDC106 chr5: 68234769-70811821 12971 2577053 4 rs6449986 rs279322 2.672 0 CCNB1 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 CCNB1 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 CCNB1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 CCNB1 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 CCND1 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 CCND1 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 CCND1 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 CCNE1 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 CCNE1 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 CCNE1 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 CCNE1 chr3: 32995928-33321616 82 325689 4 rs2228428 rs7626634 4.598 0 CCR4 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 CCR4 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 CCR4 chr3: 32439785-33321616 160 881832 3 rs347134 rs7626634 15.636 0 CCR4 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 CCR5 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 CCR5 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 CCR5 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 CD163 chr12: 7623724-7777197 30 153474 1 rs11054072 rs12308688 23.272 0 CD163 chr11: 60589137-64068310 499 3479174 1 rs656736 rs2286614 53.467 0 CD5 chr11: 60760530-60880856 31 120327 3 rs11230553 rs678060 42.25 0 CD5 chr11: 59765908-62371773 484 2605866 3 rs569225 rs2516633 35.88 0 CD5 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 CD5 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 CD5 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 CD9 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 CDC42 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 CDC42 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 CDKN2C chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 CDKN2C chr5: 82234797-92547093 1521 10312297 4 rs37545 rs10041223 14.906 0 CETN3 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 CETN3 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 CETN3 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 CETN3 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 CFTR chr7: 112666609-125975251 1866 13308643 4 rs6957202 rs496 3.945 0 CFTR chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 CFTR chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 CFTR chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 CFTR chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 CHAT chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 CHAT chr15: 40561890-65059651 4763 24497762 1 rs6492939 rs1008917 60.034 0 CHP chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 CHP chr15: 41457623-41562393 23 104771 1 rs496142 rs16971734 10.768 0 CHP chr15: 40528155-42166500 240 1638346 1 rs1017843 rs12593397 85.352 0 CHP chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 CHRM2 chr7: 136375979-137102498 151 726520 4 rs10954541 rs1647189 5.931 0 CHRM2 chr7: 117831743-152070158 6055 34238416 3 rs3808178 rs6966258 7.28 0 CHRM2 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 CHRM2 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 CHRM2 chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 CHRM2 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 CHRM3 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 CHRM3 chr1: 239472077-239774670 62 302594 3 rs12041476 rs6685121 100.034 0 CHRM3 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 CHRM3 chr10: 101320120-104213502 403 2893383 1 rs10748784 rs11191291 27.935 0 CHUK chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 CHUK chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 CHUK chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 CHUK chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 CHUK chr10: 99160152-130771382 6972 31611231 3 rs1048442 rs12258650 21.306 0 CHUK chr19: 40344648-46426076 806 6081429 1 rs12609590 rs8101540 27.283 0 CIC chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 CIC chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 CIC chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 CIC chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 CIC chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 CIC chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 CIC chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 CISH chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 CISH chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 CISH chr3: 46713865-52833805 488 6119941 1 rs3935248 rs3617 54.926 0 CISH chr5: 73958245-81276023 1632 7317779 3 rs4703640 rs4703863 22.731 0 CKMT2 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 CKMT2 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 CKMT2 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 CKMT2 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 CLTB chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 CLTB chr8: 14962494-40636979 6254 25674486 3 rs1026349 rs4403392 35.815 0 CLU chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 CLU chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 CLU chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 CMIP chr16: 69829875-88530172 5884 18700298 1 rs4985547 rs4782368 30.145 0 CMIP chr19: 1961474-14570703 2131 12609230 1 rs2041120 rs12974686 29.276 0 CNN1 chr19: 3053574-18061509 2612 15007936 3 rs7938 rs7250332 73.169 0 CNN1 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 CNN1 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 CNP chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 CNP chr6: 88318883-101197953 2546 12879071 3 rs2307389 rs1336244 20.983 0 CNR1 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 CNR1 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 CNR1 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 CNR1 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 CNR1 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 CNR1 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 CNR1 chr6: 69745723-124631456 10981 54885734 1 rs2225803 rs932600 38.287 0 CNR1 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 CNR1 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 CNR1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 CNR2 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 CNR2 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 COIL chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 COIL chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 COPB2 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 COPB2 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 COPB2 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 COPB2 chr3: 94377411-140094984 8050 45717574 3 rs9844990 rs7618673 46.041 0 COPB2 chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 COPB2 chr11: 65226187-67799926 252 2573740 1 rs1626021 rs2075626 54.033 0 CORO1B chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 CORO1B chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 CORO1B chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 CORO1B chr11: 67186000-67288594 13 102595 1 rs1790733 rs2276118 16.171 0 CORO1B chr3: 116881714-132034199 2802 15152486 3 rs7649284 rs3844501 21.439 0 COX17 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 COX17 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 COX17 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 COX17 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 COX17 chr3: 118926656-121160369 362 2233714 1 rs4591498 rs4676677 42.841 0 COX17 chr3: 94377411-140094984 8050 45717574 3 rs9844990 rs7618673 46.041 0 COX17 chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 COX17 chr4: 158105424-181967709 4468 23862286 4 rs10517663 rs4583800 8.627 0 CPE chr4: 125165157-188223037 11572 63057881 3 rs6854804 rs9993067 11.06 0 CPE chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 CPE chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 CPE chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 CPE chr4: 126959315-183880263 10103 56920949 3 rs9985873 rs2714510 50.565 0 CPE chr4: 160961893-179971852 3803 19009960 1 rs17039117 rs10034007 35.81 0 CPE chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 CPE chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 CRADD chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 CRADD chr12: 84152210-113464649 5560 29312440 1 rs10862748 rs16942470 28.181 0 CRADD chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 CREM chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 CREM chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 CRHR1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 CRHR1 chr17: 43657921-44354796 88 696876 3 rs9898857 rs2732700 28.613 0 CRHR1 chr2: 42287306-50902931 2298 8615626 3 rs988958 rs2194390 44.151 0 CRIPT chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 CRIPT chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 CRIPT chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 CRIPT chr20: 296172-665551 107 369380 1 rs6049002 rs4815889 47.808 0 CSNK2A1 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 CSNK2A2 chr6: 428722-31742590 1987 31313869 3 rs1473602 rs707928 44.729 0 CSNK2B chr6: 31281438-31880637 8674 599200 1 cnvi0006173 rs28435656 31.216 0 CSNK2B chr6: 31281438-31795082 8770 513645 1 cnvi0006173 rs5026931 58.163 0 CSNK2B chr6: 31281438-31878433 8677 596996 1 cnvi0006173 rs519417 56.15 0 CSNK2B chr6: 29877864-35562640 12719 5684777 3 rs28592582 rs3798346 61.622 0 CSNK2B chr6: 31289284-32512164 1746 1222881 3 rs9265170 rs28495356 24.02 0 CSNK2B chr6: 31281438-32354073 8034 1072636 1 cnvi0006173 rs7759813 34.729 0 CSNK2B chr6: 31289284-32499014 9991 1209731 3 rs9265170 cnvi0006585 23.466 0 CSNK2B chr6: 26430981-31878433 8001 5447453 1 rs2893848 rs519417 55.651 0 CSNK2B chr6: 31204008-32355605 1755 1151598 1 rs7745906 rs9268472 61.163 0 CSNK2B chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 CTNNB1 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 CTNNB1 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 CTNNB1 chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 CYCS chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 CYCS chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 CYCS chr19: 1961474-14570703 2131 12609230 1 rs2041120 rs12974686 29.276 0 DAPK3 chr19: 3053574-18061509 2612 15007936 3 rs7938 rs7250332 73.169 0 DAPK3 chr19: 3958397-4098776 20 140380 1 rs7255123 rs350912 17.875 0 DAPK3 chr19: 384644-4514135 854 4129492 1 rs12151104 rs4807598 56.902 0 DAPK3 chr5: 176780545-176896412 12 115868 1 rs4131289 rs2029164 11.65 0 DBN1 chr5: 176859848-177047009 12 187162 1 rs2731664 rs7727897 15.921 0 DBN1 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 DBN1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 DBN1 chr5: 176010125-180058963 954 4048839 1 rs936912 rs2290983 30.904 0 DBN1 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 DCN chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 DCN chr12: 84152210-113464649 5560 29312440 1 rs10862748 rs16942470 28.181 0 DCN chr12: 91427784-91630155 39 202372 1 rs2897929 rs1522430 13.426 0 DCN chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 DDIT4 chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 DDIT4 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 DDIT4 chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 DDIT4 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 DDX5 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 DDX5 chr17: 61016209-66240093 890 5223885 1 rs1588368 rs11658645 37.309 0 DDX5 chr17: 59314257-66170047 1135 6855791 1 rs758467 rs4558468 71.379 0 DDX5 chr8: 2289839-11706229 4078 9416391 3 rs6558648 rs1736090 47.192 0 DEFB1 chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 DGKD chr2: 211013993-242051777 6871 31037785 3 rs4673499 rs2074824 40.702 0 DGKD chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 DGKD chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 DGKD chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 DGKD chr11: 46393757-46646030 22 252274 1 rs3740976 rs7122039 13.806 0 DGKZ chr11: 38685169-55210647 1957 16525479 3 rs1026834 rs11229683 17.562 0 DGKZ chr11: 46297631-46699124 35 401494 1 rs10437653 rs8914 25.596 0 DGKZ chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 DHCR7 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 DHCR7 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 DHCR7 chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 DIRAS2 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 DIRAS2 chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 DIRAS2 chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 DIRAS2 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 DISC1 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 DISC1 chr1: 231711489-231813134 22 101646 3 rs1765782 rs6541281 33.828 0 DISC1 chr1: 231669827-231819050 26 149224 1 rs1655290 rs1417584 16.629 0 DISC1 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 DISC1 chr3: 196710530-197344176 113 633647 3 rs4916596 rs9917735 5.501 0 DLG1 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 DLG1 chr3: 196833650-197037067 16 203418 1 rs12632536 rs7620061 17.735 0 DLG1 chr3: 196833650-197037067 16 203418 1 rs12632536 rs7620061 17.971 0 DLG1 chr3: 196793858-196985596 15 191739 1 rs6795358 rs9843659 13.601 0 DLG1 chr3: 196793858-196993693 16 199836 1 rs6795358 rs406284 12.558 0 DLG1 chr3: 161695760-196993693 7208 35297934 1 rs4575917 rs406284 54.788 0 DLG1 chr3: 195401242-197744198 418 2342957 3 rs2140357 rs13327370 398.627 0 DLG1 chr3: 196793858-196935657 12 141800 1 rs6795358 rs34729751 14.018 0 DLG1 chr3: 196838486-197019935 12 181450 1 rs1356612 rs1741949 16.796 0 DLG1 chr17: 7031638-7592780 100 561143 3 rs2062737 rs2287497 12.667 0 DLG4 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 DLST chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 DLST chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 DLST chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 DNM1 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 DNM1 chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 DNM1 chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 DNM1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 DNM3 chr1: 164144117-180071987 3186 15927871 3 rs12037444 rs6425606 30.846 0 DNM3 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 DNM3 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 DNM3 chr8: 14962494-40636979 6254 25674486 3 rs1026349 rs4403392 35.815 0 DPYSL2 chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 DPYSL2 chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 DPYSL2 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 DRD1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 DRD1 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 DRD2 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 DRD2 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 DRD2 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 DRD3 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 DRD3 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 DRD3 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 DRD3 chr3: 94377411-140094984 8050 45717574 3 rs9844990 rs7618673 46.041 0 DRD3 chr3: 95055435-114675646 3559 19620212 1 rs2871719 rs16823416 41.186 0 DRD3 chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 DRD3 chr6: 56700798-57160035 58 459238 1 rs7758867 rs6459184 64.215 0 DST chr6: 54337130-68125255 1525 13788126 4 rs243768 rs9363753 26.278 0 DST chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 DST chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 DST chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 DST chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 DST chr20: 6111569-21985498 4344 15873930 3 rs6038366 rs6047798 43.161 0 DSTN chr1: 1005806-2221222 93 1215417 1 rs3934834 rs2643885 45.212 0 DVL1 chr1: 1119858-1575247 53 455390 1 rs1320565 rs6700106 30.24 0 DVL1 chr1: 949468-3587505 498 2638038 1 rs1126625 rs3765696 23.726 0 DVL1 chr1: 1254841-3342804 386 2087964 1 rs10907179 rs870171 39.259 0 DVL1 chr1: 1162435-1277903 19 115469 3 rs3766186 rs34411680 14.65 0 DVL1 chr17: 7031638-7592780 100 561143 3 rs2062737 rs2287497 12.667 0 DVL2 chr3: 183834490-184075047 45 240558 1 rs9815292 rs2228291 52.071 0 DVL3 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 DVL3 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 DVL3 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 DVL3 chr3: 161695760-196993693 7208 35297934 1 rs4575917 rs406284 54.788 0 DVL3 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 DYNLL1 chr12: 112610714-133708729 5366 21098016 3 rs11066188 rs11147249 695.45 0 DYNLL1 chr10: 133970588-135225666 210 1255079 1 rs870552 rs10857712 64.995 0 ECHS1 chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 ECHS1 chr10: 134741143-135357239 169 616097 1 rs12242379 rs1536826 34.134 0 ECHS1 chr9: 138961722-140376668 138 1414947 1 rs11103306 rs10116708 35.913 0 EDF1 chr9: 137718113-139841512 539 2123400 4 rs4842173 rs884113 1.053 0 EDF1 chr9: 138873600-140938183 302 2064584 1 cnvi0002612 rs3750506 26.611 0 EDF1 chr9: 139492789-140212642 109 719854 1 rs28485548 rs13295516 79.502 0 EDF1 chr8: 144636272-145151910 72 515639 1 rs4874150 rs2070688 30.325 0 EEF1D chr8: 144663075-144929811 38 266737 0 rs1809148 rs11779128 18.944 0 EEF1D chr8: 142245646-145744618 599 3498973 4 rs11167039 rs3757966 0 0 EEF1D chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 EEF1D chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 EEF1D chr8: 142327998-145730330 725 3402333 1 rs878422 rs35770914 173.154 0 EEF1D chr19: 1961474-14570703 2131 12609230 1 rs2041120 rs12974686 29.276 0 EEF2 chr19: 3053574-18061509 2612 15007936 3 rs7938 rs7250332 73.169 0 EEF2 chr19: 3958397-4098776 20 140380 1 rs7255123 rs350912 17.875 0 EEF2 chr19: 384644-4514135 854 4129492 1 rs12151104 rs4807598 56.902 0 EEF2 chr13: 101787253-110828119 2677 9040867 3 rs592888 rs17517971 95.857 0 EFNB2 chr13: 63692683-113075599 10941 49382917 1 rs9592243 rs9550080 27.124 0 EFNB2 chr13: 34752890-109100024 15589 74347135 1 rs2321822 rs7332707 33.721 0 EFNB2 chr13: 100580353-112257226 3428 11676874 1 rs10851110 rs1341154 52.726 0 EFNB2 chr13: 41369790-112329394 15030 70959605 3 rs1536807 rs9588495 26.915 0 EFNB2 chr13: 60985192-114224496 12638 53239305 1 rs1341840 rs4907646 40.079 0 EFNB2 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 EGFR chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 EGFR chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 EGFR chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 EIF1B chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 EIF1B chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 EIF1B chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 EN02 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 EPB41 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 EPB41 chr20: 34817545-44483225 1946 9665681 1 rs17093449 rs6130947 4536.622 0 EPB41L1 chr6: 129368803-140027836 2420 10659034 3 rs11154461 rs9321752 88.822 0 EPB41L2 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 EPB41L2 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 EPB41L2 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 EPB41L2 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 EPB41L2 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 EPB41L2 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 EPB41L2 chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 EPB41L2 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 EPB41L2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 EPHB2 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 EPHB2 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 ERBB2 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 ERBB2 chr6: 146892943-169478886 6121 22585944 3 rs12199886 rs13219463 43.565 0 ESR1 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 ESR1 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 ESR1 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 ESR1 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 ESR1 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 ESR1 chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 ESR1 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 ESR2 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 ESR2 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 ESR2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 ESRRG chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 ESRRG chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 ESRRG chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 ESRRG chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 ESRRG chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 ESRRG chr19: 40344648-46426076 806 6081429 1 rs12609590 rs8101540 27.283 0 ETHE1 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 ETHE1 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 ETHE1 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 ETHE1 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 ETHE1 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 ETHE1 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 ETHE1 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 ETHE1 chr22: 19765182-43845708 5546 24080527 1 rs4819843 rs135044 57.345 0 EWSR1 chr22: 19413706-51123505 7927 31709800 3 rs9618567 rs9616816 6.837 0 EWSR1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 F11R chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 F11R chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 F11R chr5: 73958245-81276023 1632 7317779 3 rs4703640 rs4703863 22.731 0 F2R chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 F2R chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 F2R chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 F2R chr5: 73958245-81276023 1632 7317779 3 rs4703640 rs4703863 22.731 0 F2RL2 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 F2RL2 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 F2RL2 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 F2RL2 chr19: 3053574-18061509 2612 15007936 3 rs7938 rs7250332 73.169 0 F2RL3 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 F2RL3 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 F2RL3 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 F2RL3 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 F3 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 F3 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 F3 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 FADD chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 FADD chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 FADD chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 FAS chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 FAS chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 FAS chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 FAS chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 FBLIM1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 FBLIM1 chr5: 106749690-117695003 2459 10945314 3 rs6868410 rs6882527 55.105 0 FER chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 FER chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 FER chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 FER chr5: 108410880-108534661 25 123782 1 rs17161593 rs6594352 22.436 0 FER chr5: 108243615-108346952 15 103338 1 rs4604227 rs10515397 13.382 0 FER chr5: 108243615-108490168 45 246554 1 rs4604227 rs11952637 19.486 0 FER chr5: 108390471-108490168 24 99698 1 rs10062069 rs11952637 16.894 0 FER chr5: 108284342-111242002 627 2957661 1 rs3797817 rs17133870 44.164 0 FER chr11: 114191016-134258416 5073 20067401 3 rs2847476 rs893951 4.233 0 FEZ1 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 FEZ1 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 FEZ1 chr2: 34687910-41885773 1679 7197864 4 rs2887973 rs6748566 14.365 0 FEZ2 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 FEZ2 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 FFAR1 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 FFAR1 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 FFAR1 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 FFAR1 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 FFAR1 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 FFAR1 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 FFAR2 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 FFAR2 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 FFAR2 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 FFAR2 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 FFAR2 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 FFAR2 chr14: 38111870-49524522 1996 11412653 4 rs177852 rs2273387 32.638 0 FKBP3 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 FKBP3 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 FKBP3 chr12: 62261443-72745898 2376 10484456 3 rs3759288 rs2044305 73.366 0 FLJ41278 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 FLJ41278 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 FLJ41278 chr12: 63939740-69842643 1240 5902904 3 rs513203 rs6581895 22.639 0 FLJ41278 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 FLNB chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 FLNB chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 FLNB chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 FPR1 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 FPR1 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 FPR1 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 FPR1 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 FPR1 chr12: 62261443-72745898 2376 10484456 3 rs3759288 rs2044305 73.366 0 FRS2 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 FRS2 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 FRS2 chr12: 69925695-70075933 47 150239 1 rs518634 rs775474 15.726 0 FRS2 chr2: 42287306-50902931 2298 8615626 3 rs988958 rs2194390 44.151 0 FSHR chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 FSHR chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 FSHR chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 FSHR chr15: 91379999-91525197 28 145199 1 rs7171099 rs2301826 30.169 0 FURIN chr15: 72136872-102040672 6413 29903801 3 rs4777466 rs7179692 18.158 0 FURIN chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 FURIN chr15: 73186518-94501564 4223 21315047 1 rs1947219 rs4344687 34.841 0 FURIN chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 FXN chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 FXN chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 FXN chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 FXN chr9: 40718561-72048477 498 31329917 3 rs2572590 rs2991695 24.737 0 FXN chr3: 179810898-182183458 277 2372561 4 rs1608071 rs9842478 0 0 FXR1 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 FXR1 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 FXR1 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 FXR1 chr3: 161695760-196993693 7208 35297934 1 rs4575917 rs406284 54.788 0 FXR1 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 FYN chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 FYN chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 FYN chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 FYN chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 FYN chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 FYN chr6: 93575149-115508938 4238 21933790 1 rs4707762 cnvi0021859 41.857 0 FYN chr6: 69745723-124631456 10981 54885734 1 rs2225803 rs932600 38.287 0 FYN chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 FYN chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 FYN chr6: 88318883-101197953 2546 12879071 3 rs2307389 rs1336244 20.983 0 GABRR1 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 GABRR1 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 GABRR1 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 GABRR1 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 GABRR1 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 GABRR1 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 GABRR1 chr6: 69745723-124631456 10981 54885734 1 rs2225803 rs932600 38.287 0 GABRR1 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 GABRR1 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 GABRR1 chr6: 88318883-101197953 2546 12879071 3 rs2307389 rs1336244 20.983 0 GABRR2 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 GABRR2 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 GABRR2 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 GABRR2 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 GABRR2 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 GABRR2 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 GABRR2 chr6: 69745723-124631456 10981 54885734 1 rs2225803 rs932600 38.287 0 GABRR2 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 GABRR2 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 GABRR2 chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 GALR2 chr17: 67081830-78829375 2912 11747546 1 rs2302134 rs12943041 31.498 0 GALR2 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 GALR2 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 GALR2 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 GAP43 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 GAP43 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 GAP43 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 GAP43 chr3: 94377411-140094984 8050 45717574 3 rs9844990 rs7618673 46.041 0 GAP43 chr3: 115166604-115280312 20 113709 1 rs937543 rs6777738 44.305 61839 GAP43 chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 GAP43 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 GAPDH chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 GC chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 GC chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 GC chr4: 72136575-72703606 133 567032 1 rs1377287 rs11945677 46.854 0 GC chr4: 31619950-97811299 11610 66191350 1 rs6811437 rs12644209 44.41 0 GC chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 GC chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 GC chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 GFAP chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 GFAP chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 GFI1 chr1: 91735313-93953469 318 2218157 3 rs281968 rs2624437 24.127 0 GFI1 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 GFI1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 GFI1 chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 GFI1B chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 GFI1B chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 GFI1B chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 GFI1B chr9: 133274265-137174079 1058 3899815 1 rs4573325 rs11185709 48.157 0 GFI1B chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 GFPT1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 GFPT1 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 GFPT1 chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 GFPT1 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 GH1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 GH1 chr17: 61016209-66240093 890 5223885 1 rs1588368 rs11658645 37.309 0 GH1 chr17: 59314257-66170047 1135 6855791 1 rs758467 rs4558468 71.379 0 GH1 chr17: 27831995-29897264 162 2065270 1 rs490120 rs223132 39.076 0 GH1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 GH1 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 GIT2 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 GIT2 chr12: 84152210-113464649 5560 29312440 1 rs10862748 rs16942470 28.181 0 GIT2 chr6: 120284480-125648345 1162 5363866 4 rs726178 rs9388416 4.489 0 GJA1 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 GJA1 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 GJA1 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 GJA1 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 GJA1 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 GJA1 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 GJA1 chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 GJA1 chr6: 69745723-124631456 10981 54885734 1 rs2225803 rs932600 38.287 0 GJA1 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 GJA1 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 GJA1 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 GLP1R chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 GLP1R chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 GLP1R chr14: 51834859-63624420 2657 11789562 3 rs11629344 rs4902208 13.871 0 GMFB chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 GMFB chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 GMFB chr7: 155066-5366935 926 5211870 1 rs4075778 rs10278799 26.361 0 GNA12 chr7: 2268970-2990009 143 721040 3 rs1626670 rs7806365 15.695 0 GNA12 chr7: 1809385-5133219 777 3323835 1 rs1113831 rs4339542 25.717 0 GNA12 chr19: 1961474-14570703 2131 12609230 1 rs2041120 rs12974686 29.276 0 GNA15 chr19: 3053574-18061509 2612 15007936 3 rs7938 rs7250332 73.169 0 GNA15 chr19: 1572369-3354956 351 1782588 1 rs10415156 rs4807451 45.225 0 GNA15 chr19: 384644-4514135 854 4129492 1 rs12151104 rs4807598 56.902 0 GNA15 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 GNAI1 chr7: 73178435-89984409 2908 16805975 4 rs11764572 rs42664 0.17 0 GNAI1 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 GNAI1 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 GNAI1 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 GNAI2 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 GNAI2 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 GNAI2 chr3: 46713865-52833805 488 6119941 1 rs3935248 rs3617 54.926 0 GNAI2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 GNAI3 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 GNAI3 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 GNAI3 chr16: 56362725-57226956 220 864232 3 rs2241952 rs6499871 11.443 0 GNAO1 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 GNAO1 chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 GNAQ chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 GNAQ chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 GNAQ chr9: 77857783-82347458 1181 4489676 1 rs12000663 rs4387054 36.701 0 GNAQ chr9: 80201301-80528757 54 327457 1 rs1162211 rs7033572 30.324 0 GNAQ chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 GNAQ chr20: 57387854-57517574 23 129721 1 rs6015380 rs6092708 23.326 0 GNAS chr20: 50459530-62198348 3263 11738819 3 rs6063722 rs438363 11.693 0 GNAS chr22: 19765182-43845708 5546 24080527 1 rs4819843 rs135044 57.345 0 GNAZ chr22: 19413706-51123505 7927 31709800 3 rs9618567 rs9616816 6.837 0 GNAZ chr22: 22351365-25906803 1041 3555439 3 rs5756388 rs476240 238.835 0 GNAZ chr22: 22998337-23649242 126 650906 1 rs6003181 rs131693 276.751 0 GNAZ chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 GOT1 chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 GOT1 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 GOT1 chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 GOT1 chr10: 99160152-130771382 6972 31611231 3 rs1048442 rs12258650 21.306 0 GOT1 chr17: 4739161-4891956 27 152796 3 rs9900036 rs426475 13.756 0 GP1BA chr4: 158105424-181967709 4468 23862286 4 rs10517663 rs4583800 8.627 0 GPM6A chr4: 125165157-188223037 11572 63057881 3 rs6854804 rs9993067 11.06 0 GPM6A chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 GPM6A chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 GPM6A chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 GPM6A chr4: 126959315-183880263 10103 56920949 3 rs9985873 rs2714510 50.565 0 GPM6A chr4: 160961893-179971852 3803 19009960 1 rs17039117 rs10034007 35.81 0 GPM6A chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 GPM6A chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 GPR26 chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 GPR26 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 GPR26 chr10: 99160152-130771382 6972 31611231 3 rs1048442 rs12258650 21.306 0 GPR26 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 GPSM2 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 GPSM2 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 GPSM2 chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 GRB14 chr2: 163048404-167430697 750 4382294 4 rs13399624 rs10208695 0 0 GRB14 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 GRB14 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 GRB14 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 GRB14 chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 GRB2 chr17: 67081830-78829375 2912 11747546 1 rs2302134 rs12943041 31.498 0 GRB2 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 GRB2 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 GRB2 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 GRB7 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 GRB7 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 GRIA1 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 GRIA1 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 GRIA1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 GRIA1 chr4: 158105424-181967709 4468 23862286 4 rs10517663 rs4583800 8.627 0 GRIA2 chr4: 125165157-188223037 11572 63057881 3 rs6854804 rs9993067 11.06 0 GRIA2 chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 GRIA2 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 GRIA2 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 GRIA2 chr4: 126959315-183880263 10103 56920949 3 rs9985873 rs2714510 50.565 0 GRIA2 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 GRIA2 chr4: 155739051-165849854 1997 10110804 1 rs7691720 rs10005938 26.215 0 GRIA2 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 GRIA4 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 GRIA4 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 GRIA4 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 GRIK1 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 GRIK1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 GRIK1 chr21: 27808458-44731138 4502 16922681 1 rs150760 rs504022 45.745 0 GRIK1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 GRIK1 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 GRIK1 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 GRIK1 chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 GRIK1 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 GRIK1 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 GRIK1 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 GRIK1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 GRIK1 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 GRIK1 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 GRIK1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 GRIK3 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 GRIK3 chr9: 138961722-140376668 138 1414947 1 rs11103306 rs10116708 35.913 0 GRIN1 chr9: 139973820-140301447 33 327628 1 rs7037849 rs11516126 24.432 0 GRIN1 chr9: 138873600-140938183 302 2064584 1 cnvi0002612 rs3750506 26.611 0 GRIN1 chr9: 139492789-140212642 109 719854 1 rs28485548 rs13295516 79.502 0 GRIN1 chr12: 11740163-33217793 5315 21477631 3 rs10491981 rs12424662 69.717 0 GRIN2B chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 GRIN2B chr4: 1224811-7063524 1270 5838714 1 rs4974574 rs6836129 27.935 0 GRK4 chr4: 415311-15136380 3262 14721070 3 rs7695712 rs2702525 10.287 0 GRK4 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 GRK4 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 GRM1 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 GRM1 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 GRM1 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 GRM1 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 GRM1 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 GRM1 chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 GRM1 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 GRM1 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 GRM2 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 GRM2 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 GRM2 chr3: 46713865-52833805 488 6119941 1 rs3935248 rs3617 54.926 0 GRM2 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 GRM3 chr7: 73178435-89984409 2908 16805975 4 rs11764572 rs42664 0.17 0 GRM3 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 GRM3 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 GRM3 chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 GRM3 chr7: 86022840-86137490 20 114651 1 rs3903590 rs6980352 14.813 135740 GRM3 chr6: 29877864-35562640 12719 5684777 3 rs28592582 rs3798346 61.622 0 GRM4 chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 GRM4 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 GRM4 chr11: 88533414-91714466 456 3181053 4 rs10501688 rs7940613 8.733 0 GRM5 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 GRM5 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 GRM5 chr11: 88325804-88962090 140 636287 1 rs1504088 rs11018542 30.5 0 GRM5 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 GRM5 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 GRM6 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 GRM6 chr5: 176010125-180058963 954 4048839 1 rs936912 rs2290983 30.904 0 GRM6 chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 GRM7 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 GRM7 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 GRM8 chr7: 126354618-131010943 857 4656326 3 rs1018878 rs3823483 28.648 0 GRM8 chr7: 117831743-152070158 6055 34238416 3 rs3808178 rs6966258 7.28 0 GRM8 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 GRM8 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 GRM8 chr7: 125999649-126219766 52 220118 1 rs714237 rs2299470 25.109 0 GRM8 chr7: 125676925-125927493 48 250569 1 rs1419535 rs17600450 37.913 151159 GRM8 chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 GRM8 chr7: 125676925-125780682 24 103758 1 rs1419535 rs10267757 26.358 297970 GRM8 chr19: 40344648-46426076 806 6081429 1 rs12609590 rs8101540 27.283 0 GSK3A chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 GSK3A chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 GSK3A chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 GSK3A chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 GSK3A chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 GSK3A chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 GSK3A chr3: 116881714-132034199 2802 15152486 3 rs7649284 rs3844501 21.439 0 GSK3B chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 GSK3B chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 GSK3B chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 GSK3B chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 GSK3B chr3: 118926656-121160369 362 2233714 1 rs4591498 rs4676677 42.841 0 GSK3B chr3: 94377411-140094984 8050 45717574 3 rs9844990 rs7618673 46.041 0 GSK3B chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 GSK3B chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 GSN chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 GSN chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 GSN chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 GSN chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 GSTM4 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 GSTM4 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 GSTM4 chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 HABP4 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 HABP4 chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 HABP4 chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 HABP4 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 HAND1 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 HAND1 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 HAND1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 HAND1 chr4: 158105424-181967709 4468 23862286 4 rs10517663 rs4583800 8.627 0 HAND2 chr4: 125165157-188223037 11572 63057881 3 rs6854804 rs9993067 11.06 0 HAND2 chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 HAND2 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 HAND2 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 HAND2 chr4: 126959315-183880263 10103 56920949 3 rs9985873 rs2714510 50.565 0 HAND2 chr4: 160961893-179971852 3803 19009960 1 rs17039117 rs10034007 35.81 0 HAND2 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 HAND2 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 HARS chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 HARS chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 HARS chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 HBXIP chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 HBXIP chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 HBXIP chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 HES1 chr3: 161695760-196993693 7208 35297934 1 rs4575917 rs406284 54.788 0 HES1 chr6: 428722-31742590 1987 31313869 3 rs1473602 rs707928 44.729 0 HLA-A chr6: 19044000-31286381 6774 12242382 1 rs6922929 rs9265057 31.6 0 HLA-A chr6: 2681610-31453618 81 28772009 1 rs1131896 rs9267212 428.052 0 HLA-A chr6: 3764851-31298743 7861 27533893 3 rs28880026 rs28752863 40.215 0 HLA-A chr6: 3772684-31298743 7858 27526060 3 rs12661707 rs28752863 27.127 0 HLA-A chr6: 29877864-35562640 12719 5684777 3 rs28592582 rs3798346 61.622 0 HLA-A chr6: 2681610-31453113 80 28771504 3 rs1131896 rs2904600 359.691 0 HLA-A chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 40.382 0 HLA-A chr6: 11677538-31289284 4992 19611747 1 rs2022016 rs9265170 68.97 0 HLA-A chr6: 29864203-31294687 11756 1430485 3 rs9259437 rs28752836 6.497 0 HLA-A chr6: 19812444-31286381 6951 11473938 1 rs16882740 rs9265057 32.473 0 HLA-A chr6: 29812471-29937541 221 125071 1 rs7452613 rs11752303 122.513 0 HLA-A chr6: 26430981-31878433 8001 5447453 1 rs2893848 rs519417 55.651 0 HLA-A chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 34.598 0 HLA-A chr6: 2681610-31453618 81 28772009 3 rs1131896 rs9267212 390.234 0 HLA-A chr6: 428722-31742590 1987 31313869 3 rs1473602 rs707928 44.729 0 HLA-C chr6: 30858991-31300796 709 441806 3 rs2524257 rs9265668 31.123 0 HLA-C chr6: 19044000-31286381 6774 12242382 1 rs6922929 rs9265057 31.6 0 HLA-C chr6: 2681610-31453618 81 28772009 1 rs1131896 rs9267212 428.052 0 HLA-C chr6: 3764851-31298743 7861 27533893 3 rs28880026 rs28752863 40.215 0 HLA-C chr6: 3772684-31298743 7858 27526060 3 rs12661707 rs28752863 27.127 0 HLA-C chr6: 29877864-35562640 12719 5684777 3 rs28592582 rs3798346 61.622 0 HLA-C chr6: 2681610-31453113 80 28771504 3 rs1131896 rs2904600 359.691 0 HLA-C chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 40.382 0 HLA-C chr6: 11677538-31289284 4992 19611747 1 rs2022016 rs9265170 68.97 0 HLA-C chr6: 29864203-31294687 11756 1430485 3 rs9259437 rs28752836 6.497 0 HLA-C chr6: 19812444-31286381 6951 11473938 1 rs16882740 rs9265057 32.473 0 HLA-C chr6: 26430981-31878433 8001 5447453 1 rs2893848 rs519417 55.651 0 HLA-C chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 34.598 0 HLA-C chr6: 2681610-31453618 81 28772009 3 rs1131896 rs9267212 390.234 0 HLA-C chr6: 31204008-32355605 1755 1151598 1 rs7745906 rs9268472 61.163 0 HLA-C chr6: 29877864-35562640 12719 5684777 3 rs28592582 rs3798346 61.622 0 HLA-DQA2 chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 HLA-DQA2 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 HLA-DQA2 chr6: 32505531-32895580 7668 390050 1 cnvi0006586 rs9501239 48.21 0 HLA-DQA2 chr13: 19496434-50144613 7295 30648180 3 rs1838114 rs11148151 43.395 0 HMGB1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 HMGN1 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 HMGN1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 HMGN1 chr21: 27808458-44731138 4502 16922681 1 rs150760 rs504022 45.745 0 HMGN1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 HMGN1 chr21: 37312170-45589727 2506 8277558 1 rs1573303 rs4818886 41.534 0 HMGN1 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 HMGN1 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 HMGN1 chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 HMGN1 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 HMGN1 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 HMGN1 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 HMGN1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 HMGN1 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 HMGN1 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 HMGN1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 HMGN2 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 HMGN2 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 HMMR chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 HMMR chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 HMMR chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 HMMR chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 HMP19 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 HMP19 chr5: 73958245-81276023 1632 7317779 3 rs4703640 rs4703863 22.731 0 HOMER1 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 HOMER1 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 HOMER1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 HOMER1 chr5: 76450190-79622472 726 3172283 1 rs6864250 rs2405378 35.823 0 HOMER1 chr5: 78542290-79057477 95 515188 1 rs10474578 rs259126 38.26 0 HOMER1 chr15: 72136872-102040672 6413 29903801 3 rs4777466 rs7179692 18.158 0 HOMER2 chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 HOMER2 chr15: 73186518-94501564 4223 21315047 1 rs1947219 rs4344687 34.841 0 HOMER2 chr19: 18892728-19054720 20 161993 1 rs10038 rs4808883 49.554 0 HOMER3 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 HOMER3 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 HOMER3 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 HOMER3 chr18: 13708574-28197518 1970 14488945 4 rs4796995 rs2542754 1.046 0 HRH4 chr14: 102003864-105246686 423 3242823 1 rs1190712 rs2494738 38.435 0 HSP90AA1 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 HSP90AA1 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 HSP90AA1 chr6: 41773322-45545975 754 3772654 3 rs2153878 rs7764616 22.895 0 HSP90AB1 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 HSP90AB1 chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 HSP90AB1 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 HSP90AB1 chr6: 31281438-31880637 8674 599200 1 cnvi0006173 rs28435656 31.216 0 HSPA1A chr6: 31281438-31795082 8770 513645 1 cnvi0006173 rs5026931 58.163 0 HSPA1A chr6: 31281438-31878433 8677 596996 1 cnvi0006173 rs519417 56.15 0 HSPA1A chr6: 29877864-35562640 12719 5684777 3 rs28592582 rs3798346 61.622 0 HSPA1A chr6: 31289284-32512164 1746 1222881 3 rs9265170 rs28495356 24.02 0 HSPA1A chr6: 31281438-32354073 8034 1072636 1 cnvi0006173 rs7759813 34.729 0 HSPA1A chr6: 31289284-32499014 9991 1209731 3 rs9265170 cnvi0006585 23.466 0 HSPA1A chr6: 26430981-31878433 8001 5447453 1 rs2893848 rs519417 55.651 0 HSPA1A chr6: 31204008-32355605 1755 1151598 1 rs7745906 rs9268472 61.163 0 HSPA1A chr6: 31281438-31880637 8674 599200 1 cnvi0006173 rs28435656 31.216 0 HSPA1B chr6: 31281438-31795082 8770 513645 1 cnvi0006173 rs5026931 58.163 0 HSPA1B chr6: 31281438-31878433 8677 596996 1 cnvi0006173 rs519417 56.15 0 HSPA1B chr6: 29877864-35562640 12719 5684777 3 rs28592582 rs3798346 61.622 0 HSPA1B chr6: 31289284-32512164 1746 1222881 3 rs9265170 rs28495356 24.02 0 HSPA1B chr6: 31281438-32354073 8034 1072636 1 cnvi0006173 rs7759813 34.729 0 HSPA1B chr6: 31289284-32499014 9991 1209731 3 rs9265170 cnvi0006585 23.466 0 HSPA1B chr6: 26430981-31878433 8001 5447453 1 rs2893848 rs519417 55.651 0 HSPA1B chr6: 31204008-32355605 1755 1151598 1 rs7745906 rs9268472 61.163 0 HSPA1B chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 HSPA4 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 HSPA4 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 HSPA4 chr5: 132036252-133013438 246 977187 1 rs1468216 rs1558188 37.296 0 HSPA4 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 HSPB1 chr7: 73178435-89984409 2908 16805975 4 rs11764572 rs42664 0.17 0 HSPB1 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 HSPB1 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 HSPB1 chr7: 75337644-77143217 201 1805574 1 rs10954377 rs6976567 29.447 0 HSPB1 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 HSPB3 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 HSPB3 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 HSPB8 chr12: 112610714-133708729 5366 21098016 3 rs11066188 rs11147249 695.45 0 HSPB8 chr19: 54743217-58326001 842 3582785 3 rs17239607 rs2303817 41.312 0 HSPBP1 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 HSPBP1 chr19: 55590671-55994156 87 403486 1 rs1671163 cnvi0009418 33.877 0 HSPBP1 chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 HSPE1 chr2: 197839329-199705667 272 1866339 3 rs6754223 rs1518095 20.552 0 HSPE1 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 HSPE1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 HSPE1 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 HSPE1 chr2: 185221268-213136747 4656 27915480 1 rs17501385 rs2135161 31.832 0 HSPE1 chr13: 19496434-50144613 7295 30648180 3 rs1838114 rs11148151 43.395 0 HSPH1 chr13: 19496434-50144613 7295 30648180 3 rs1838114 rs11148151 43.395 0 HTR2A chr13: 34752890-109100024 15589 74347135 1 rs2321822 rs7332707 33.721 0 HTR2A chr13: 41369790-112329394 15030 70959605 3 rs1536807 rs9588495 26.915 0 HTR2A chr13: 46975365-56115403 1925 9140039 1 rs7333428 rs9537164 28.591 0 HTR2A chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 HTR2B chr2: 211013993-242051777 6871 31037785 3 rs4673499 rs2074824 40.702 0 HTR2B chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 HTR2B chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 HTR2B chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 HTR2B chr2: 231913056-232047561 18 134506 1 rs3731783 rs7585622 16.163 0 HTR2B chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 HTR6 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 HTR6 chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 IKBKB chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 IKBKB chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 IKBKB chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 IKBKE chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 IKBKE chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 IKBKE chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 IKBKE chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 IKBKE chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 IKBKE chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 IL4R chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 IL5RA chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 IL5RA chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 IMPDH2 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 IMPDH2 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 IMPDH2 chr3: 46713865-52833805 488 6119941 1 rs3935248 rs3617 54.926 0 IMPDH2 chr19: 1961474-14570703 2131 12609230 1 rs2041120 rs12974686 29.276 0 INSR chr19: 3053574-18061509 2612 15007936 3 rs7938 rs7250332 73.169 0 INSR chr3: 121415720-121614175 25 198456 1 rs3732410 rs1881998 19.972 0 IQCB1 chr3: 116881714-132034199 2802 15152486 3 rs7649284 rs3844501 21.439 0 IQCB1 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 IQCB1 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 IQCB1 chr3: 121406253-121670405 37 264153 1 rs7430165 rs9871743 14.269 0 IQCB1 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 IQCB1 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 IQCB1 chr3: 94377411-140094984 8050 45717574 3 rs9844990 rs7618673 46.041 0 IQCB1 chr3: 121526849-121670405 23 143557 1 rs6770719 rs9871743 13.308 0 IQCB1 chr3: 121453361-121564989 15 111629 1 rs9841861 rs6767409 18.746 0 IQCB1 chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 IQCB1 chr15: 72136872-102040672 6413 29903801 3 rs4777466 rs7179692 18.158 0 IQGAP1 chr15: 90471917-91108674 116 636758 1 rs1256854 rs8031453 41.393 0 IQGAP1 chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 IQGAP1 chr15: 73186518-94501564 4223 21315047 1 rs1947219 rs4344687 34.841 0 IQGAP1 chr5: 73958245-81276023 1632 7317779 3 rs4703640 rs4703863 22.731 0 IQGAP2 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 IQGAP2 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 IQGAP2 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 IQGAP2 chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 IRS1 chr2: 211013993-242051777 6871 31037785 3 rs4673499 rs2074824 40.702 0 IRS1 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 IRS1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 IRS1 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 IRS1 chr10: 28216167-33956346 1404 5740180 3 rs6481494 rs2891376 43.482 0 ITGB1 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 ITGB1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 ITGB2 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 ITGB2 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 ITGB2 chr21: 41509457-47941916 1911 6432460 3 rs741802 rs2096507 27.753 0 ITGB2 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 ITGB2 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 ITGB2 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 ITGB2 chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 ITGB2 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 ITGB2 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 ITGB2 chr21: 44744540-47642272 785 2897733 1 rs10084596 rs2280957 41.824 0 ITGB2 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 ITGB2 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 ITGB2 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 ITGB2 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 ITGB2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 ITGB3BP chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 ITGB3BP chr1: 63914117-64047615 16 133499 1 rs3009577 rs10127824 22.702 0 ITGB3BP chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 ITGB4 chr17: 67081830-78829375 2912 11747546 1 rs2302134 rs12943041 31.498 0 ITGB4 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 ITGB4 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 ITGB4 chr3: 116881714-132034199 2802 15152486 3 rs7649284 rs3844501 21.439 0 ITGB5 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 ITGB5 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 ITGB5 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 ITGB5 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 ITGB5 chr3: 94377411-140094984 8050 45717574 3 rs9844990 rs7618673 46.041 0 ITGB5 chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 ITGB5 chr12: 53517820-53621711 14 103892 3 rs2280697 rs10082776 3.878 0 ITGB7 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 ITGB7 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 ITGB7 chr15: 40561890-65059651 4763 24497762 1 rs6492939 rs1008917 60.034 0 ITPKA chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 ITPKA chr15: 40528155-42166500 240 1638346 1 rs1017843 rs12593397 85.352 0 ITPKA chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 ITPKB chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 ITPKB chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 ITPKB chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 ITPKB chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 ITPKB chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 ITPKB chr1: 226423572-227452700 215 1029129 1 rs6605032 rs1969230 24.875 0 ITPKB chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 ITPR1 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 ITPR1 chr6: 29877864-35562640 12719 5684777 3 rs28592582 rs3798346 61.622 0 ITPR3 chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 ITPR3 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 ITPR3 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 JAK1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 JAK1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 KCNE1 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 KCNE1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 KCNE1 chr21: 27808458-44731138 4502 16922681 1 rs150760 rs504022 45.745 0 KCNE1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 KCNE1 chr21: 35725729-35904697 49 178969 3 rs11702479 rs7280739 62.338 0 KCNE1 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 KCNE1 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 KCNE1 chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 KCNE1 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 KCNE1 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 KCNE1 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 KCNE1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 KCNE1 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 KCNE1 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 KCNE1 chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 KCNE4 chr2: 211013993-242051777 6871 31037785 3 rs4673499 rs2074824 40.702 0 KCNE4 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 KCNE4 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 KCNE4 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 KCNE4 chr7: 150634448-150837529 34 203082 3 rs758887 rs10230113 4.01 0 KCNH2 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 KCNH2 chr7: 117831743-152070158 6055 34238416 3 rs3808178 rs6966258 7.28 0 KCNH2 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 KCNH2 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 KCNH2 chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 KCNH2 chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 KCNJ2 chr17: 67081830-78829375 2912 11747546 1 rs2302134 rs12943041 31.498 0 KCNJ2 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 KCNJ2 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 KCNJ2 chr5: 106749690-117695003 2459 10945314 3 rs6868410 rs6882527 55.105 0 KCNN2 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 KCNN2 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 KCNN2 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 KCNN2 chr19: 40344648-46426076 806 6081429 1 rs12609590 rs8101540 27.283 0 KCNN4 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 KCNN4 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 KCNN4 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 KCNN4 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 KCNN4 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 KCNN4 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 KCNN4 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 KCNN4 chr20: 61839585-62212928 58 373344 1 rs6090305 rs310672 25.348 0 KCNQ2 chr20: 61852629-62219837 59 367209 1 rs6010873 rs1151621 42.234 0 KCNQ2 chr20: 62092342-62385479 46 293138 1 rs6122454 rs7273624 63.019 0 KCNQ2 chr20: 61852629-62212928 57 360300 1 rs6010873 rs310672 32.584 0 KCNQ2 chr20: 50459530-62198348 3263 11738819 3 rs6063722 rs438363 11.693 0 KCNQ2 chr20: 61585706-62404416 145 818711 1 rs2093045 rs6062521 36.155 0 KCNQ2 chr20: 61158952-62230974 254 1072023 1 rs11906462 rs432717 39.681 0 KCNQ2 chr20: 61008620-62751454 409 1742835 1 rs2427340 rs13039817 86.487 0 KCNQ2 chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 KCNQ3 chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 KCNQ3 chr8: 84037048-138506934 11020 54469887 1 rs13265895 rs1849692 72.228 0 KCNQ3 chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 KCNQ3 chr6: 68563328-76635743 1594 8072416 3 rs1399225 rs9343330 47.996 0 KCNQ5 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 KCNQ5 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 KCNQ5 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 KCNQ5 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 KCNQ5 chr6: 69745723-124631456 10981 54885734 1 rs2225803 rs932600 38.287 0 KCNQ5 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 KCNQ5 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 KCNQ5 chr4: 53893156-57457918 721 3564763 3 rs17082301 rs7670824 14.755 0 KDR chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 KDR chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 KDR chr4: 31619950-97811299 11610 66191350 1 rs6811437 rs12644209 44.41 0 KDR chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 KDR chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 KDR chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 KIAA0090 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 KIAA0090 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 KIAA1377 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 KIAA1377 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 KIAA1377 chr11: 99019894-103408327 1272 4388434 1 rs11218556 rs1471602 67.436 0 KIAA1377 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 KIAA1549 chr7: 117831743-152070158 6055 34238416 3 rs3808178 rs6966258 7.28 0 KIAA1549 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 KIAA1549 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 KIAA1549 chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 KIAA1549 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 KIAA1683 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 KIAA1683 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 KIAA1683 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 KIF3A chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 KIF3A chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 KIF3A chr5: 132036252-133013438 246 977187 1 rs1468216 rs1558188 37.296 0 KIF3A chr5: 132039132-132142277 13 103146 1 rs2285700 rs2057825 14.409 0 KIF3A chr5: 132042146-132142277 11 100132 1 rs3798130 rs2057825 13.579 0 KIF3A chr4: 53893156-57457918 721 3564763 3 rs17082301 rs7670824 14.755 0 KIT chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 KIT chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 KIT chr4: 31619950-97811299 11610 66191350 1 rs6811437 rs12644209 44.41 0 KIT chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 KIT chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 KIT chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 KLHL20 chr1: 164144117-180071987 3186 15927871 3 rs12037444 rs6425606 30.846 0 KLHL20 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 KLHL20 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 KLHL20 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 KLHL3 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 KLHL3 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 KLHL3 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 KLK10 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 KLK10 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 KLK10 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 KLK10 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 KLK10 chr12: 11740163-33217793 5315 21477631 3 rs10491981 rs12424662 69.717 0 KRAS chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 KRAS chr12: 25274593-25385910 26 111318 1 rs2220195 rs11047912 19.553 0 KRAS chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 KRT10 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 KRT10 chr12: 52746294-53521658 273 775365 3 rs1625785 rs12581102 23.895 0 KRT18 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 KRT18 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 KRT18 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 LAMA4 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 LAMA4 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 LAMA4 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 LAMA4 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 LAMA4 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 LAMA4 chr6: 93575149-115508938 4238 21933790 1 rs4707762 cnvi0021859 41.857 0 LAMA4 chr6: 69745723-124631456 10981 54885734 1 rs2225803 rs932600 38.287 0 LAMA4 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 LAMA4 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 LAMA4 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 LCK chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 LCK chr22: 19765182-43845708 5546 24080527 1 rs4819843 rs135044 57.345 0 LGALS2 chr22: 19413706-51123505 7927 31709800 3 rs9618567 rs9616816 6.837 0 LGALS2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 LMNA chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 LMNA chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 LMNA chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 LMNB1 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 LMNB1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 LMNB1 chr8: 142200731-144657600 499 2456870 1 rs2288997 rs2290416 58.39 0 LOC100133669 chr8: 142245646-145744618 599 3498973 4 rs11167039 rs3757966 0 0 LOC100133669 chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 LOC100133669 chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 LOC100133669 chr8: 142327998-145730330 725 3402333 1 rs878422 rs35770914 173.154 0 LOC100133669 chr6: 129368803-140027836 2420 10659034 3 rs11154461 rs9321752 88.822 0 LOC154092 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 LOC154092 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 LOC154092 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 LOC154092 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 LOC154092 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 LOC154092 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 LOC154092 chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 LOC154092 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 LOC154092 chr18: 2412278-7343763 1314 4931486 3 rs16943205 rs9949998 70.845 0 LOC339290 chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 LOC340357 chr8: 11876689-15051158 1245 3174470 1 rs10096955 rs7840505 34.251 0 LOC340357 chr8: 11876689-15051158 1245 3174470 1 rs10096955 rs7840505 32.747 0 LOC340357 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 LOC400604 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 LOC400604 chr4: 182173261-187358040 1508 5184780 3 rs11930209 rs4862695 63.646 0 LRP2BP chr4: 125165157-188223037 11572 63057881 3 rs6854804 rs9993067 11.06 0 LRP2BP chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 LRP2BP chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 LRP2BP chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 LRRC59 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 LRRC59 chr6: 428722-31742590 1987 31313869 3 rs1473602 rs707928 44.729 0 LTA chr6: 31281438-31880637 8674 599200 1 cnvi0006173 rs28435656 31.216 0 LTA chr6: 31281438-31795082 8770 513645 1 cnvi0006173 rs5026931 58.163 0 LTA chr6: 31281438-31878433 8677 596996 1 cnvi0006173 rs519417 56.15 0 LTA chr6: 29877864-35562640 12719 5684777 3 rs28592582 rs3798346 61.622 0 LTA chr6: 31289284-32512164 1746 1222881 3 rs9265170 rs28495356 24.02 0 LTA chr6: 31281438-32354073 8034 1072636 1 cnvi0006173 rs7759813 34.729 0 LTA chr6: 31289284-32499014 9991 1209731 3 rs9265170 cnvi0006585 23.466 0 LTA chr6: 26430981-31878433 8001 5447453 1 rs2893848 rs519417 55.651 0 LTA chr6: 31204008-32355605 1755 1151598 1 rs7745906 rs9268472 61.163 0 LTA chr14: 22513116-32242747 1997 9729632 1 rs4982546 rs17098165 31.673 0 LTB4R chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 LTF chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 LTF chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 LTF chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 LXN chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 LXN chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 LXN chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 LXN chr4: 1224811-7063524 1270 5838714 1 rs4974574 rs6836129 27.935 0 LYAR chr4: 415311-15136380 3262 14721070 3 rs7695712 rs2702525 10.287 0 LYAR chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 LYAR chr8: 56589428-56906068 65 316641 3 rs7460004 rs10282821 88.674 0 LYN chr8: 53363937-64107847 2115 10743911 3 rs284818 rs2043525 25.971 0 LYN chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 LYN chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 LYN chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 LYN chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 LYST chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 LYST chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 LYST chr6: 41773322-45545975 754 3772654 3 rs2153878 rs7764616 22.895 0 MAD2L1BP chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 MAD2L1BP chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 MAD2L1BP chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 MAD2L1BP chr15: 40561890-65059651 4763 24497762 1 rs6492939 rs1008917 60.034 0 MAP1A chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 MAP1A chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 MAP2K1 chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 MAP2K5 chr19: 40344648-46426076 806 6081429 1 rs12609590 rs8101540 27.283 0 MAP3K10 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 MAP3K10 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 MAP3K10 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 MAP3K10 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 MAP3K10 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 MAP3K10 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 MAP3K10 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 MAP3K3 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 MAP3K3 chr17: 61016209-66240093 890 5223885 1 rs1588368 rs11658645 37.309 0 MAP3K3 chr17: 59314257-66170047 1135 6855791 1 rs758467 rs4558468 71.379 0 MAP3K3 chr6: 88318883-101197953 2546 12879071 3 rs2307389 rs1336244 20.983 0 MAP3K7 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 MAP3K7 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 MAP3K7 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 MAP3K7 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 MAP3K7 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 MAP3K7 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 MAP3K7 chr6: 69745723-124631456 10981 54885734 1 rs2225803 rs932600 38.287 0 MAP3K7 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 MAP3K7 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 MAP3K7 chr10: 28216167-33956346 1404 5740180 3 rs6481494 rs2891376 43.482 0 MAP3K8 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 MAP3K8 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 MAP4 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 MAP4 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 MAP4 chr3: 46713865-52833805 488 6119941 1 rs3935248 rs3617 54.926 0 MAP4 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 MAP6 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 MAP6 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 MAP6 chr22: 19765182-43845708 5546 24080527 1 rs4819843 rs135044 57.345 0 MAPK1 chr22: 17394989-22573637 1104 5178649 3 rs1860945 rs12159423 32.25 0 MAPK1 chr22: 19413706-51123505 7927 31709800 3 rs9618567 rs9616816 6.837 0 MAPK1 chr22: 18877787-23040362 1092 4162576 3 rs2543958 rs5996349 1181.316 0 MAPK1 chr22: 21939675-22971768 397 1032094 1 rs5754217 rs9620151 562.05 0 MAPK1 chr6: 35949497-36165213 38 215717 1 rs12664249 rs4713936 16.27 0 MAPK14 chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 MAPK14 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 MAPK14 chr16: 28301487-31147548 157 2846062 1 rs9939450 rs2855475 36.755 0 MAPK3 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 MAPK3 chr16: 29130999-33612830 601 4481832 3 rs12922496 rs2067108 21.218 0 MAPK3 chr16: 28642242-33612830 684 4970589 4 rs34954049 rs2067108 4.025 0 MAPK3 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 MAPT chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 MAPT chr17: 43657921-44354796 88 696876 3 rs9898857 rs2732700 28.613 0 MAPT chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 MARCKS chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 MARCKS chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 MARCKS chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 MARCKS chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 MARCKS chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 MARCKS chr6: 93575149-115508938 4238 21933790 1 rs4707762 cnvi0021859 41.857 0 MARCKS chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 MARCKS chr6: 69745723-124631456 10981 54885734 1 rs2225803 rs932600 38.287 0 MARCKS chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 MARCKS chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 MARCKS chr19: 40344648-46426076 806 6081429 1 rs12609590 rs8101540 27.283 0 MARK4 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 MARK4 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 MARK4 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 MARK4 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 MARK4 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 MARK4 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 MARK4 chr18: 69640030-78015180 2471 8375151 1 rs4891968 rs12960632 5752.588 0 MBP chr18: 62041997-76047493 3846 14005497 1 rs1421538 rs8085865 33.212 0 MBP chr18: 55225777-67600991 3130 12375215 3 rs1736442 rs11151547 39.543 0 MC4R chr18: 46577218-63087976 3720 16510759 1 rs357893 rs487555 37.146 0 MC4R chr18: 58316345-58573151 29 256807 1 rs9964060 rs7233420 16.278 276344 MC4R chr5: 112566758-112688123 28 121366 1 rs12521391 rs11241201 15.251 0 MCC chr5: 106749690-117695003 2459 10945314 3 rs6868410 rs6882527 55.105 0 MCC chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 MCC chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 MCC chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 MCC chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 MGMT chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 MGMT chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 MIP chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 MIP chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 MLF2 chr9: 18485176-22183781 1066 3698606 3 rs2153415 rs866666 59.138 0 MLLT3 chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 MLLT3 chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 MLLT3 chr14: 51834859-63624420 2657 11789562 3 rs11629344 rs4902208 13.871 0 MNAT1 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 MNAT1 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 MNAT1 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 MNAT1 chr14: 60826810-61530401 106 703592 1 rs17097373 rs4902024 40.432 0 MNAT1 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 MPHOSPH6 chr16: 69829875-88530172 5884 18700298 1 rs4985547 rs4782368 30.145 0 MPHOSPH6 chr6: 41773322-45545975 754 3772654 3 rs2153878 rs7764616 22.895 0 MRPL14 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 MRPL14 chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 MRPL14 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 MRPL14 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 MRPS12 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 MRPS12 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 MRPS12 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 MRPS12 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 MRPS12 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 MRPS12 chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 MRPS16 chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 MRPS16 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 MRPS16 chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 MRPS16 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 MRPS6 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 MRPS6 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 MRPS6 chr21: 27808458-44731138 4502 16922681 1 rs150760 rs504022 45.745 0 MRPS6 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 MRPS6 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 MRPS6 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 MRPS6 chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 MRPS6 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 MRPS6 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 MRPS6 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 MRPS6 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 MRPS6 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 MRPS6 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 MRPS6 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 MTHFD1 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 MTHFD1 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 MTHFD1 chr14: 64926097-65063315 19 137219 1 rs2281603 rs10134770 14.377 0 MTHFD1 chr4: 125165157-188223037 11572 63057881 3 rs6854804 rs9993067 11.06 0 MTNR1A chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 MTNR1A chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 MTNR1B chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 MTNR1B chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 MTNR1B chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 MX1 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 MX1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 MX1 chr21: 41509457-47941916 1911 6432460 3 rs741802 rs2096507 27.753 0 MX1 chr21: 27808458-44731138 4502 16922681 1 rs150760 rs504022 45.745 0 MX1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 MX1 chr21: 37312170-45589727 2506 8277558 1 rs1573303 rs4818886 41.534 0 MX1 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 MX1 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 MX1 chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 MX1 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 MX1 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 MX1 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 MX1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 MX1 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 MX1 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 MX1 chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 MYC chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 MYC chr8: 84037048-138506934 11020 54469887 1 rs13265895 rs1849692 72.228 0 MYC chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 MYC chr12: 76374448-83556258 1351 7181811 3 rs7976486 rs4394896 27.448 0 MYF5 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 MYF5 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 MYF5 chr12: 80848400-87509441 1110 6661042 1 cnvi0015213 rs12231093 33.999 0 MYF5 chr12: 76374448-83556258 1351 7181811 3 rs7976486 rs4394896 27.448 0 MYF6 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 MYF6 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 MYF6 chr12: 80848400-87509441 1110 6661042 1 cnvi0015213 rs12231093 33.999 0 MYF6 chr3: 116881714-132034199 2802 15152486 3 rs7649284 rs3844501 21.439 0 MYLK chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 MYLK chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 MYLK chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 MYLK chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 MYLK chr3: 94377411-140094984 8050 45717574 3 rs9844990 rs7618673 46.041 0 MYLK chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 MYLK chr5: 16654960-17268112 182 613153 3 rs379803 rs298595 6.286 0 MYO10 chr5: 15481973-19212516 808 3730544 1 rs16903891 rs4472262 2959.007 0 MYO10 chr5: 6100526-29461973 4878 23361448 3 rs307186 rs16898985 13.817 0 MYO10 chr6: 68563328-76635743 1594 8072416 3 rs1399225 rs9343330 47.996 0 MYO6 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 MYO6 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 MYO6 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 MYO6 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 MYO6 chr6: 69745723-124631456 10981 54885734 1 rs2225803 rs932600 38.287 0 MYO6 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 MYO6 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 MYO6 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 MYO7A chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 MYO7A chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 MYO7A chr19: 3053574-18061509 2612 15007936 3 rs7938 rs7250332 73.169 0 MYO9B chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 MYO9B chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 MYO9B chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 MYO9B chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 MYOC chr1: 164144117-180071987 3186 15927871 3 rs12037444 rs6425606 30.846 0 MYOC chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 MYOC chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 MYOC chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 MYOG chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 MYOG chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 MYOG chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 MYOG chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 MYOG chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 MYOG chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 MYOT chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 MYOT chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 MYOT chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 NACA chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 NACA chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 NANS chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 NANS chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 NANS chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 NANS chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 NCALD chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 NCALD chr8: 84037048-138506934 11020 54469887 1 rs13265895 rs1849692 72.228 0 NCALD chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 NCALD chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 NCF1C chr7: 73178435-89984409 2908 16805975 4 rs11764572 rs42664 0.17 0 NCF1C chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 NCF1C chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 NCF1C chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 NCK1 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 NCK1 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 NCK1 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 NCK1 chr3: 94377411-140094984 8050 45717574 3 rs9844990 rs7618673 46.041 0 NCK1 chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 NCK1 chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 NCL chr2: 211013993-242051777 6871 31037785 3 rs4673499 rs2074824 40.702 0 NCL chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 NCL chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 NCL chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 NCL chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 NCOR2 chr12: 112610714-133708729 5366 21098016 3 rs11066188 rs11147249 695.45 0 NCOR2 chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 NEUROD1 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 NEUROD1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 NEUROD1 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 NEUROD1 chr22: 19765182-43845708 5546 24080527 1 rs4819843 rs135044 57.345 0 NF2 chr22: 19413706-51123505 7927 31709800 3 rs9618567 rs9616816 6.837 0 NF2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 NFASC chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 NFASC chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 NFASC chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 NFASC chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 NFASC chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 NFASC chr18: 76715856-77595649 176 879794 1 rs1789250 rs635436 31.255 0 NFATC1 chr18: 75773172-77730807 462 1957636 3 rs11665253 rs1134231 32.533 0 NFATC1 chr18: 69640030-78015180 2471 8375151 1 rs4891968 rs12960632 5752.588 0 NFATC1 chr18: 77220616-77368374 53 147759 1 rs7236492 rs4799069 31.995 0 NFATC1 chr10: 101320120-104213502 403 2893383 1 rs10748784 rs11191291 27.935 0 NFKB2 chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 NFKB2 chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 NFKB2 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 NFKB2 chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 NFKB2 chr10: 99160152-130771382 6972 31611231 3 rs1048442 rs12258650 21.306 0 NFKB2 chr14: 32903616-37374768 1191 4471153 3 rs2383302 rs17105665 31.38 0 NFKBIA chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 NFKBIA chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 NFKBIB chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 NFKBIB chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 NFKBIB chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 NFKBIB chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 NFKBIB chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 NFKBIB chr6: 41773322-45545975 754 3772654 3 rs2153878 rs7764616 22.895 0 NFKBIE chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 NFKBIE chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 NFKBIE chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 NFKBIE chr14: 77532672-77856184 101 323513 1 rs4899635 rs12435136 36.527 0 NGB chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 NGB chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 NGB chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 NGB chr22: 19765182-43845708 5546 24080527 1 rs4819843 rs135044 57.345 0 NHP2L1 chr22: 19413706-51123505 7927 31709800 3 rs9618567 rs9616816 6.837 0 NHP2L1 chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 NMI chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 NMI chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 NMI chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 NMI chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 NOS1 chr12: 112610714-133708729 5366 21098016 3 rs11066188 rs11147249 695.45 0 NOS1 chr2: 110857243-110982530 14 125288 3 rs6716800 rs13386516 15.231 0 NPHP1 chr2: 110829655-110982530 15 152876 3 rs163667 rs13386516 35.326 0 NPHP1 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 NPHP1 chr2: 110829655-110982530 15 152876 3 rs163667 rs13386516 4.71 0 NPHP1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 NPHP1 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 NPHP1 chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 NPHP1 chr2: 110871665-110983050 21 111386 1 rs17842653 rs10173717 72.747 0 NPHP1 chr2: 110844047-111144295 29 300249 3 rs163642 rs2117529 113.269 0 NPHP1 chr2: 110871665-110974623 19 102959 1 rs17842653 rs10793770 55.985 0 NPHP1 chr2: 110844047-110983050 24 139004 3 rs163642 rs10173717 73.48 0 NPHP1 chr2: 110732676-110983050 31 250375 3 rs12467706 rs10173717 85.922 0 NPHP1 chr2: 110732676-110983050 31 250375 3 rs12467706 rs10173717 105.897 0 NPHP1 chr2: 110732676-111068787 32 336112 3 rs12467706 rs339216 109.625 0 NPHP1 chr4: 149196991-157601193 1461 8404203 3 rs6812904 rs10030015 30.798 0 NPY2R chr4: 125165157-188223037 11572 63057881 3 rs6854804 rs9993067 11.06 0 NPY2R chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 NPY2R chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 NPY2R chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 NPY2R chr4: 126959315-183880263 10103 56920949 3 rs9985873 rs2714510 50.565 0 NPY2R chr4: 148566463-156666845 1395 8100383 1 rs17475359 rs6814688 54.297 0 NPY2R chr4: 156087185-156213709 21 126525 1 rs10030872 rs983146 15.037 0 NPY2R chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 NPY2R chr4: 155739051-165849854 1997 10110804 1 rs7691720 rs10005938 26.215 0 NPY2R chr2: 27083489-28057823 90 974335 4 rs6756245 rs4666022 2.006 0 NRBP1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 NRBP1 chr11: 114191016-134258416 5073 20067401 3 rs2847476 rs893951 4.233 0 NRGN chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 NRGN chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 NRGN chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 NUCB1 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 NUCB1 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 NUCB1 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 NUCB1 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 NUCB1 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 NUCB1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 NUDC chr1: 27161670-27475785 31 314116 3 rs11247599 rs11247613 40.308 0 NUDC chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 NUDC chr1: 228216997-228500627 33 283631 1 rs708122 rs2087121 53.416 0 OBSCN chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 OBSCN chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 OBSCN chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 OBSCN chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 OBSCN chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 OBSCN chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 OGG1 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 OGG1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 OPRD1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 OPRD1 chr8: 53363937-64107847 2115 10743911 3 rs284818 rs2043525 25.971 0 OPRK1 chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 OPRK1 chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 OPRK1 chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 OPRK1 chr6: 146892943-169478886 6121 22585944 3 rs12199886 rs13219463 43.565 0 OPRM1 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 OPRM1 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 OPRM1 chr6: 153869625-153994951 17 125327 1 rs9478436 rs4296898 20.643 336680 OPRM1 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 OPRM1 chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 OPRM1 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 P2RY1 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 P2RY1 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 P2RY1 chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 P2RY1 chr12: 56466128-56658859 14 192732 1 rs12831884 rs1274500 18.792 0 PA2G4 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 PA2G4 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 PA2G4 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 PABPC4 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 PABPC4 chr9: 137718113-139841512 539 2123400 4 rs4842173 rs884113 1.053 0 PAEP chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 PAEP chr9: 137308462-139406491 681 2098030 1 rs3118536 rs3124602 43.969 0 PAEP chr19: 40344648-46426076 806 6081429 1 rs12609590 rs8101540 27.283 0 PAFAH1B3 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 PAFAH1B3 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 PAFAH1B3 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 PAFAH1B3 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 PAFAH1B3 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 PAFAH1B3 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 PAFAH1B3 chr5: 97242130-106564497 1369 9322368 4 rs4596407 rs4957697 38.782 0 PAM chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 PAM chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 PAM chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 PAM chr5: 101558083-102529401 120 971319 1 rs4323206 rs26819 39.848 0 PAM chr5: 102079057-102721744 64 642688 3 rs1645534 rs10463994 23.12 0 PAM chr16: 66659818-69310136 211 2650319 1 rs165207 rs153047 34.961 0 PARD6A chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 PARD6A chr16: 67634786-67780829 11 146044 1 cnvi0008013 rs9925393 12.023 0 PARD6A chr18: 69640030-78015180 2471 8375151 1 rs4891968 rs12960632 5752.588 0 PARD6G chr18: 77417934-78015180 120 597247 1 rs2460386 rs12960632 213.038 0 PARD6G chr12: 76374448-83556258 1351 7181811 3 rs7976486 rs4394896 27.448 0 PAWR chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 PAWR chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 PAWR chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 PCBP1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 PCBP1 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 PCBP1 chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 PCBP1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 PCBP3 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 PCBP3 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 PCBP3 chr21: 46466674-47652185 275 1185512 1 rs4819020 rs2839160 84.642 0 PCBP3 chr21: 41509457-47941916 1911 6432460 3 rs741802 rs2096507 27.753 0 PCBP3 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 PCBP3 chr21: 47091361-47265786 27 174426 1 rs2838973 rs1009577 13.147 0 PCBP3 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 PCBP3 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 PCBP3 chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 PCBP3 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 PCBP3 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 PCBP3 chr21: 44744540-47642272 785 2897733 1 rs10084596 rs2280957 41.824 0 PCBP3 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 PCBP3 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 PCBP3 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 PCBP3 chr21: 46381900-48098560 448 1716661 1 rs8132265 cnvi0019195 712.68 0 PCBP3 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 PCBP3 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 PCDHA4 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 PCDHA4 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 PCDHA4 chr6: 146892943-169478886 6121 22585944 3 rs12199886 rs13219463 43.565 0 PCMT1 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 PCMT1 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 PCMT1 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 PCMT1 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 PCMT1 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 PCMT1 chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 PCMT1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 PCNT chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 PCNT chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 PCNT chr21: 47566828-47863025 61 296198 1 rs7282864 rs2073379 29.607 0 PCNT chr21: 41509457-47941916 1911 6432460 3 rs741802 rs2096507 27.753 0 PCNT chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 PCNT chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 PCNT chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 PCNT chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 PCNT chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 PCNT chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 PCNT chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 PCNT chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 PCNT chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 PCNT chr21: 46381900-48098560 448 1716661 1 rs8132265 cnvi0019195 712.68 0 PCNT chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 PCNT chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 PCP4 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 PCP4 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 PCP4 chr21: 27808458-44731138 4502 16922681 1 rs150760 rs504022 45.745 0 PCP4 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 PCP4 chr21: 37312170-45589727 2506 8277558 1 rs1573303 rs4818886 41.534 0 PCP4 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 PCP4 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 PCP4 chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 PCP4 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 PCP4 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 PCP4 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 PCP4 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 PCP4 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 PCP4 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 PCP4 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 PDC chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 PDC chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 PDC chr1: 186345497-186467274 17 121778 3 rs12733799 rs3901950 67.838 0 PDC chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 PDC chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 PDC chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 PDCD5 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 PDCD5 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 PDCD5 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 PDCD5 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 PDCD5 chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 PDCL chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 PDCL chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 PDCL chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 PDCL chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 PDE1A chr2: 183175422-184652758 268 1477337 3 rs1347732 rs12477832 10.153 0 PDE1A chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 PDE1A chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 PDE1A chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 PDE1A chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 PDE1B chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 PDE1B chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 PDE1C chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 PDE1C chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 PDE1C chr1: 120123179-145747463 154 25624285 3 rs6428833 rs1284300 54.961 0 PDE4DIP chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 PDE4DIP chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 PDE4DIP chr1: 144570551-144850451 10 279901 3 rs7534126 cnvi0020739 2.437 0 PDE4DIP chr1: 145033984-145385675 37 351692 3 rs1627675 cnvi0018364 4.42 0 PDE4DIP chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 PDE4DIP chr1: 144570551-144844630 9 274080 3 rs7534126 cnvi0022936 17.575 0 PDE4DIP chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 PDE6D chr2: 211013993-242051777 6871 31037785 3 rs4673499 rs2074824 40.702 0 PDE6D chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 PDE6D chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 PDE6D chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 PDE6D chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 PDE6G chr17: 79150654-81047708 15608 1897055 1 rs12103867 rs35680231 31.668 0 PDE6G chr5: 176859848-177047009 12 187162 1 rs2731664 rs7727897 15.921 0 PDLIM7 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 PDLIM7 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 PDLIM7 chr5: 176010125-180058963 954 4048839 1 rs936912 rs2290983 30.904 0 PDLIM7 chr16: 570623-4436445 673 3865823 1 rs2071978 rs1298104 51.749 0 PDPK1 chr16: 2263146-4436445 367 2173300 1 rs26849 rs1298104 37.458 0 PDPK1 chr16: 2585237-2718424 18 133188 3 cnvi0007822 rs9941225 49.411 0 PDPK1 chr16: 1102701-4445327 629 3342627 1 rs11248851 rs3747579 101.908 0 PDPK1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 PEA15 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 PEA15 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 PEA15 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 PELO chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 PELO chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 PFDN1 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 PFDN1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 PFDN1 chr20: 50459530-62198348 3263 11738819 3 rs6063722 rs438363 11.693 0 PFDN4 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 PFDN5 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 PFDN5 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 PFKFB2 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 PFKFB2 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 PFKFB2 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 PFKFB2 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 PFKFB2 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 PFKFB2 chr17: 4739161-4891956 27 152796 3 rs9900036 rs426475 13.756 0 PFN1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 PGM1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 PGM1 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 PHKB chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 PHKG1 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 PHKG1 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 PHKG1 chr16: 28301487-31147548 157 2846062 1 rs9939450 rs2855475 36.755 0 PHKG2 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 PHKG2 chr16: 29130999-33612830 601 4481832 3 rs12922496 rs2067108 21.218 0 PHKG2 chr16: 28642242-33612830 684 4970589 4 rs34954049 rs2067108 4.025 0 PHKG2 chr19: 1961474-14570703 2131 12609230 1 rs2041120 rs12974686 29.276 0 PIAS4 chr19: 3053574-18061509 2612 15007936 3 rs7938 rs7250332 73.169 0 PIAS4 chr19: 3958397-4098776 20 140380 1 rs7255123 rs350912 17.875 0 PIAS4 chr19: 384644-4514135 854 4129492 1 rs12151104 rs4807598 56.902 0 PIAS4 chr22: 19765182-43845708 5546 24080527 1 rs4819843 rs135044 57.345 0 PICK1 chr22: 19413706-51123505 7927 31709800 3 rs9618567 rs9616816 6.837 0 PICK1 chr18: 39652939-39800893 25 147955 3 rs1941526 rs1461702 12.565 0 PIK3C3 chr3: 178310836-179125585 142 814750 3 rs7636991 rs13074663 6.695 0 PIK3CA chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 PIK3CA chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 PIK3CA chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 PIK3CA chr3: 161695760-196993693 7208 35297934 1 rs4575917 rs406284 54.788 0 PIK3CA chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 PIK3CG chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 PIK3CG chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 PIK3CG chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 PIK3CG chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 PIK3R1 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 PIK3R1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 PIK3R1 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 PLA2G7 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 PLA2G7 chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 PLA2G7 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 PLA2G7 chr20: 6111569-21985498 4344 15873930 3 rs6038366 rs6047798 43.161 0 PLCB1 chr15: 40561890-65059651 4763 24497762 1 rs6492939 rs1008917 60.034 0 PLCB2 chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 PLCB2 chr15: 40528155-42166500 240 1638346 1 rs1017843 rs12593397 85.352 0 PLCB2 chr11: 63907079-64027888 19 120810 1 rs7112960 rs915987 17.869 0 PLCB3 chr11: 60589137-64068310 499 3479174 1 rs656736 rs2286614 53.467 0 PLCB3 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 PLCB3 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 PLCB3 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 PLCB3 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 PLCD1 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 PLCD1 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 PLCG2 chr16: 69829875-88530172 5884 18700298 1 rs4985547 rs4782368 30.145 0 PLCG2 chr3: 160836006-176261513 2782 15425508 4 rs1599389 rs1377820 17.004 0 PLD1 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 PLD1 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 PLD1 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 PLD1 chr3: 171354364-171471364 11 117001 1 rs9863761 rs11708205 15.642 0 PLD1 chr3: 161695760-196993693 7208 35297934 1 rs4575917 rs406284 54.788 0 PLD1 chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 PLD1 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 PLEKHA4 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 PLEKHA4 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 PLEKHA4 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 PLEKHA4 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 PLEKHA4 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 PLEKHA4 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 PLK1 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 POLA2 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 POLA2 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 POLA2 chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 POLB chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 POLB chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 POLB chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 POLR2C chr20: 6111569-21985498 4344 15873930 3 rs6038366 rs6047798 43.161 0 POLR3F chr22: 19413706-51123505 7927 31709800 3 rs9618567 rs9616816 6.837 0 PPARA chr22: 42297214-50784013 2780 8486800 1 rs5996083 cnvi0018414 44.478 0 PPARA chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 PPEF2 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 PPEF2 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 PPEF2 chr4: 31619950-97811299 11610 66191350 1 rs6811437 rs12644209 44.41 0 PPEF2 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 PPEF2 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 PPEF2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 PPIH chr1: 42204406-46534543 635 4330138 1 rs710231 rs785512 33.167 0 PPIH chr1: 42601214-43343707 101 742494 1 rs7516178 rs11210746 136.315 0 PPIH chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 PPIH chr14: 51834859-63624420 2657 11789562 3 rs11629344 rs4902208 13.871 0 PPM1A chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 PPM1A chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 PPM1A chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 PPM1A chr14: 102003864-105246686 423 3242823 1 rs1190712 rs2494738 38.435 0 PPP1R13B chr14: 104004311-106009572 243 2005262 4 rs8014069 rs10134526 0.055 0 PPP1R13B chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 PPP1R13B chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 PPP1R13B chr14: 103987140-104657760 112 670621 1 rs2071407 rs947006 30.372 0 PPP1R13B chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 PPP1R14A chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 PPP1R14A chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 PPP1R14A chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 PPP1R14A chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 PPP1R14A chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 PPP1R14A chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 PPP2R1A chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 PPP2R1A chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 PPP2R1A chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 PPP2R1A chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 PPP2R1A chr4: 101274858-103233207 334 1958350 3 rs13130455 rs6822371 16.146 0 PPP3CA chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 PPP3CA chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 PPP3CA chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 PPP3CA chr4: 102252696-102504356 22 251661 3 rs1348161 rs2723048 4.732 0 PPP3CA chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 PPP3CA chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 PPP3CA chr10: 45475917-50393013 531 4917097 3 rs3758402 rs1962336 9.307 0 PPYR1 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 PPYR1 chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 PPYR1 chr10: 46990728-47703613 36 712886 4 rs7898282 rs4128664 15.172 0 PPYR1 chr10: 46928388-47703613 103 775226 3 rs7915055 rs4128664 164.836 0 PPYR1 chr10: 46961667-47121726 11 160060 3 rs506372 rs6599598 28.69 0 PPYR1 chr10: 46928388-47703613 103 775226 3 rs7915055 rs4128664 175.561 0 PPYR1 chr10: 46961667-47748912 104 787246 3 rs506372 rs3013867 125.384 0 PPYR1 chr10: 46961667-47703613 102 741947 3 rs506372 rs4128664 209.662 0 PPYR1 chr10: 46961667-47703613 102 741947 3 rs506372 rs4128664 209.38 0 PPYR1 chr10: 46961667-47748912 104 787246 3 rs506372 rs3013867 193.803 0 PPYR1 chr10: 46961667-47121726 11 160060 3 rs506372 rs6599598 27.148 0 PPYR1 chr10: 46961667-47099529 9 137863 3 rs506372 rs4481963 12.939 0 PPYR1 chr10: 46961667-47748912 104 787246 3 rs506372 rs3013867 204.165 0 PPYR1 chr10: 45666965-47640344 231 1973380 1 rs2275847 rs12775238 32.992 0 PPYR1 chr10: 46961667-47748912 104 787246 3 rs506372 rs3013867 192.605 0 PPYR1 chr10: 46961667-47099529 9 137863 3 rs506372 rs4481963 32.973 0 PPYR1 chr10: 47028331-47748912 101 720582 3 rs9794206 rs3013867 107.726 0 PPYR1 chr10: 45248943-47697026 345 2448084 3 rs1749328 rs4466762 230.892 0 PPYR1 chr10: 46961667-47748912 104 787246 3 rs506372 rs3013867 112.753 0 PPYR1 chr10: 46961667-47748912 104 787246 3 rs506372 rs3013867 176.786 0 PPYR1 chr10: 46961667-47149117 12 187451 3 rs506372 rs4979753 9.651 0 PPYR1 chr10: 46961667-47121726 11 160060 3 rs506372 rs6599598 22.41 0 PPYR1 chr10: 46961667-47121726 11 160060 3 rs506372 rs6599598 14.105 0 PPYR1 chr10: 47020220-47121726 9 101507 3 rs4434936 rs6599598 12.985 0 PPYR1 chr10: 47020220-47121726 9 101507 3 rs4434936 rs6599598 18.624 0 PPYR1 chr10: 46961667-47121726 11 160060 3 rs506372 rs6599598 27.741 0 PPYR1 chr10: 46928388-47099529 10 171142 3 rs7915055 rs4481963 5.293 0 PPYR1 chr10: 46892172-47748912 107 856741 3 cnvi0015924 rs3013867 225.487 0 PPYR1 chr10: 46892172-47149117 15 256946 3 cnvi0015924 rs4979753 35.314 0 PPYR1 chr10: 46961667-47121726 11 160060 3 rs506372 rs6599598 13.506 0 PPYR1 chr10: 46961667-47121726 11 160060 3 rs506372 rs6599598 21.312 0 PPYR1 chr10: 46961667-47121726 11 160060 3 rs506372 rs6599598 15.771 0 PPYR1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 PRDX1 chr1: 42204406-46534543 635 4330138 1 rs710231 rs785512 33.167 0 PRDX1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 PRDX1 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 PRG2 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 PRG2 chr19: 1961474-14570703 2131 12609230 1 rs2041120 rs12974686 29.276 0 PRKACA chr19: 3053574-18061509 2612 15007936 3 rs7938 rs7250332 73.169 0 PRKACA chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 PRKACA chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 PRKCA chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 PRKCA chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 PRKCA chr17: 63761021-67215712 732 3454692 1 cnvi0008594 rs12941264 55.59 0 PRKCA chr17: 61016209-66240093 890 5223885 1 rs1588368 rs11658645 37.309 0 PRKCA chr17: 59314257-66170047 1135 6855791 1 rs758467 rs4558468 71.379 0 PRKCA chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 PRKCD chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 PRKCD chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 PRKCD chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 PRKCG chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 PRKCG chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 PRKCG chr3: 160836006-176261513 2782 15425508 4 rs1599389 rs1377820 17.004 0 PRKCI chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 PRKCI chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 PRKCI chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 PRKCI chr3: 161695760-196993693 7208 35297934 1 rs4575917 rs406284 54.788 0 PRKCI chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 PRKCI chr1: 1005806-2221222 93 1215417 1 rs3934834 rs2643885 45.212 0 PRKCZ chr1: 1310924-2756621 137 1445698 4 rs2765033 rs4648384 8.675 0 PRKCZ chr1: 949468-3587505 498 2638038 1 rs1126625 rs3765696 23.726 0 PRKCZ chr1: 1325677-2379248 158 1053572 1 cnvi0005318 rs11581548 37.498 0 PRKCZ chr1: 1254841-3342804 386 2087964 1 rs10907179 rs870171 39.259 0 PRKCZ chr10: 52338100-60396065 1797 8057966 4 rs10508930 rs920259 44.979 0 PRKG1 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 PRKG1 chr10: 53375420-53565318 40 189899 1 rs2339794 rs1937652 16.368 0 PRKG1 chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 PRKG1 chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 PRLHR chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 PRLHR chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 PRLHR chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 PRLHR chr10: 99160152-130771382 6972 31611231 3 rs1048442 rs12258650 21.306 0 PRLHR chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 PRMT1 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 PRMT1 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 PRMT1 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 PRMT1 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 PRMT1 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 PRMT1 chr17: 74204592-79532654 1324 5328063 1 rs4505373 rs3934711 38.57 0 PRPSAP1 chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 PRPSAP1 chr17: 67081830-78829375 2912 11747546 1 rs2302134 rs12943041 31.498 0 PRPSAP1 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 PRPSAP1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 PRPSAP1 chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 PSAT1 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 PSAT1 chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 PSAT1 chr9: 77857783-82347458 1181 4489676 1 rs12000663 rs4387054 36.701 0 PSAT1 chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 PSAT1 chr9: 81057409-81234650 49 177242 3 rs4498630 rs11137772 24.969 112400 PSAT1 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 PSEN1 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 PSEN1 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 PSEN1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 PSEN2 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 PSEN2 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 PSEN2 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 PSEN2 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 PSEN2 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 PSEN2 chr1: 226423572-227452700 215 1029129 1 rs6605032 rs1969230 24.875 0 PSEN2 chr19: 40344648-46426076 806 6081429 1 rs12609590 rs8101540 27.283 0 PSG9 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 PSG9 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 PSG9 chr19: 43561722-43840088 25 278367 1 rs7260189 rs2159134 43.869 0 PSG9 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 PSG9 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 PSG9 chr19: 43561722-43840088 71 278367 1 rs7260189 rs2159134 133.515 0 PSG9 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 PSG9 chr19: 43663086-43840088 54 177003 1 rs12460930 rs2159134 105.96 0 PSG9 chr19: 43306156-43774853 61 468698 3 rs10412335 rs11672322 80.781 0 PSG9 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 PSG9 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 PSG9 chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 PSMA2 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 PSMA2 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 PSMA2 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 PSMC1 chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 PSMC1 chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 PSMC1 chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 PSMD1 chr2: 211013993-242051777 6871 31037785 3 rs4673499 rs2074824 40.702 0 PSMD1 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 PSMD1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 PSMD1 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 PSMD1 chr2: 231913056-232047561 18 134506 1 rs3731783 rs7585622 16.163 0 PSMD1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 PSMD11 chr11: 198510-5875867 1467 5677358 3 rs3802985 rs2045046 49.035 0 PSMD13 chr11: 219089-1139111 206 920023 1 rs511744 rs11245979 38.286 0 PSMD13 chr3: 183834490-184075047 45 240558 1 rs9815292 rs2228291 52.071 0 PSMD2 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 PSMD2 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 PSMD2 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 PSMD2 chr3: 161695760-196993693 7208 35297934 1 rs4575917 rs406284 54.788 0 PSMD2 chr3: 60053331-70925955 2977 10872625 3 rs2630173 rs9856621 30.024 0 PSMD6 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 PSMD6 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 PSMD6 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 PSMD6 chr14: 22513116-32242747 1997 9729632 1 rs4982546 rs17098165 31.673 0 PSME1 chr13: 20305992-21816281 325 1510290 1 rs9551991 rs4769156 48.772 0 PSPC1 chr13: 19496434-50144613 7295 30648180 3 rs1838114 rs11148151 43.395 0 PSPC1 chr13: 19969463-21689630 329 1720168 1 rs1977696 rs4769152 31.548 0 PSPC1 chr13: 20220659-20498817 52 278159 3 rs1057093 rs7993500 198.33 0 PSPC1 chr13: 20097277-20574373 93 477097 3 rs7329280 rs6490506 49.84 0 PSPC1 chr13: 20338643-20442879 14 104237 1 rs4769903 rs9552026 14.251 0 PSPC1 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 PTGIR chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 PTGIR chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 PTGIR chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 PTGIR chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 PTGIR chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 PTGIR chr6: 54337130-68125255 1525 13788126 4 rs243768 rs9363753 26.278 0 PTP4A1 chr6: 58044218-68542695 999 10498478 3 rs6459325 rs12663045 1.613 0 PTP4A1 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 PTP4A1 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 PTP4A1 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 PTP4A1 chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 PTP4A1 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 PTP4A1 chr8: 142200731-144657600 499 2456870 1 rs2288997 rs2290416 58.39 0 PTP4A3 chr8: 142245646-145744618 599 3498973 4 rs11167039 rs3757966 0 0 PTP4A3 chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 PTP4A3 chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 PTP4A3 chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 PTP4A3 chr8: 142327998-145730330 725 3402333 1 rs878422 rs35770914 173.154 0 PTP4A3 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 PTPN11 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 PTPN11 chr12: 84152210-113464649 5560 29312440 1 rs10862748 rs16942470 28.181 0 PTPN11 chr12: 112610714-133708729 5366 21098016 3 rs11066188 rs11147249 695.45 0 PTPN11 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 PTPN12 chr7: 73178435-89984409 2908 16805975 4 rs11764572 rs42664 0.17 0 PTPN12 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 PTPN12 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 PTPN12 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 PTPN6 chr20: 2725678-3792226 227 1066549 1 rs4815541 rs2282128 45.362 0 PTPRA chr20: 2901540-3053255 31 151716 1 rs6138952 rs2740210 22.977 0 PTPRA chr20: 2901540-3048537 28 146998 1 rs6138952 rs11697250 15.163 0 PTPRA chr11: 46875933-49938930 224 3062998 1 rs6485700 rs10839448 49.109 0 PTPRJ chr11: 38685169-55210647 1957 16525479 3 rs1026834 rs11229683 17.562 0 PTPRJ chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 PTPRJ chr11: 48182237-48343904 21 161668 3 rs1039481 rs7105212 23.642 0 PTPRJ chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 PTPRJ chr19: 1961474-14570703 2131 12609230 1 rs2041120 rs12974686 29.276 0 PTPRS chr19: 3053574-18061509 2612 15007936 3 rs7938 rs7250332 73.169 0 PTPRS chr19: 5109701-5220900 20 111200 1 rs1017821 rs10412973 14.552 0 PTPRS chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 PTPRU chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 PTPRU chr12: 120396295-120709064 35 312770 1 rs4767865 rs3999561 29.821 0 PXN chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 PXN chr12: 112610714-133708729 5366 21098016 3 rs11066188 rs11147249 695.45 0 PXN chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 PYGL chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 PYGL chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 PYGM chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 PYGM chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 PYGM chr17: 74204592-79532654 1324 5328063 1 rs4505373 rs3934711 38.57 0 QRICH2 chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 QRICH2 chr17: 67081830-78829375 2912 11747546 1 rs2302134 rs12943041 31.498 0 QRICH2 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 QRICH2 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 QRICH2 chr15: 40561890-65059651 4763 24497762 1 rs6492939 rs1008917 60.034 0 RAB27A chr15: 55352945-57955569 529 2602625 3 rs1528462 rs11071339 40.481 0 RAB27A chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 RAB27A chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 RAB3B chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 RAB3B chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 RAB5A chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 RAB5A chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 RAB5A chr15: 40561890-65059651 4763 24497762 1 rs6492939 rs1008917 60.034 0 RAB8B chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 RAB8B chr15: 61102657-66474044 1173 5371388 1 rs12441037 rs4776758 171.764 0 RAB8B chr19: 40344648-46426076 806 6081429 1 rs12609590 rs8101540 27.283 0 RABAC1 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 RABAC1 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 RABAC1 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 RABAC1 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 RABAC1 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 RABAC1 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 RABAC1 chr7: 6155873-6567114 60 411242 1 rs10272684 rs1105664 18.629 0 RAC1 chr7: 5881293-9154302 917 3273010 3 rs10278352 rs172399 41.999 0 RAC1 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 RACGAP1 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 RACGAP1 chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 RAF1 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 RAF1 chr7: 16882053-54801714 9067 37919662 3 rs1404966 rs10499749 78.964 0 RALA chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 RALA chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 RALA chr2: 119935802-128867841 1515 8932040 3 rs935361 rs6747421 14.116 0 RALB chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 RALB chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 RALB chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 RALB chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 RALB chr2: 116260745-130688292 2685 14427548 3 rs1868327 rs10928943 1170.496 0 RALB chr22: 18877787-21462353 510 2584567 1 rs2543958 rs140392 1090.228 0 RANBP1 chr22: 19765182-43845708 5546 24080527 1 rs4819843 rs135044 57.345 0 RANBP1 chr22: 19025381-20228542 296 1203162 1 rs6623 rs701428 38.244 0 RANBP1 chr22: 17394989-22573637 1104 5178649 3 rs1860945 rs12159423 32.25 0 RANBP1 chr22: 19413706-51123505 7927 31709800 3 rs9618567 rs9616816 6.837 0 RANBP1 chr22: 18877787-21462353 512 2584567 1 rs2543958 rs140392 360.702 0 RANBP1 chr22: 18877787-23040362 1092 4162576 3 rs2543958 rs5996349 1181.316 0 RANBP1 chr22: 19735854-20155192 142 419339 1 rs6518580 rs373747 36.567 0 RANBP1 chr22: 19613784-21462353 380 1848570 3 rs5993743 rs140392 153.49 0 RANBP1 chr22: 18877787-21461274 612 2583488 3 rs2543958 rs140391 1388.235 0 RANBP1 chr13: 63692683-113075599 10941 49382917 1 rs9592243 rs9550080 27.124 0 RAP2A chr13: 34752890-109100024 15589 74347135 1 rs2321822 rs7332707 33.721 0 RAP2A chr13: 41369790-112329394 15030 70959605 3 rs1536807 rs9588495 26.915 0 RAP2A chr13: 60985192-114224496 12638 53239305 1 rs1341840 rs4907646 40.079 0 RAP2A chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 RASSF1 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 RASSF1 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 RASSF1 chr3: 46713865-52833805 488 6119941 1 rs3935248 rs3617 54.926 0 RASSF1 chr14: 22580623-23729402 375 1148780 1 rs1040302 rs2144039 40.668 0 RBM23 chr14: 22513116-32242747 1997 9729632 1 rs4982546 rs17098165 31.673 0 RBM23 chr14: 22513116-24480333 636 1967218 1 rs4982546 rs4982844 28.02 0 RBM23 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 RBM5 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 RBM5 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 RBM5 chr3: 46713865-52833805 488 6119941 1 rs3935248 rs3617 54.926 0 RBM5 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 RCC1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 RCC1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 RCC2 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 RCC2 chr2: 54984424-67416189 2413 12431766 3 rs980644 rs12473913 14.927 0 REL chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 REL chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 REL chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 REL chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 REL chr11: 65226187-67799926 252 2573740 1 rs1626021 rs2075626 54.033 0 RELA chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 RELA chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 RELA chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 RELA chr19: 40344648-46426076 806 6081429 1 rs12609590 rs8101540 27.283 0 RELB chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 RELB chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 RELB chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 RELB chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 RELB chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 RELB chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 RELB chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 RFC5 chr12: 112610714-133708729 5366 21098016 3 rs11066188 rs11147249 695.45 0 RFC5 chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 RGS10 chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 RGS10 chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 RGS10 chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 RGS10 chr10: 99160152-130771382 6972 31611231 3 rs1048442 rs12258650 21.306 0 RGS10 chr4: 1224811-7063524 1270 5838714 1 rs4974574 rs6836129 27.935 0 RGS12 chr4: 415311-15136380 3262 14721070 3 rs7695712 rs2702525 10.287 0 RGS12 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 RGS12 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 RGS13 chr1: 186642429-197195650 1628 10553222 4 rs2206593 rs4915406 24.676 0 RGS13 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 RGS13 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 RGS13 chr1: 188735336-196495566 1363 7760231 1 rs10754227 rs6693594 68.665 0 RGS13 chr1: 188802542-196412070 1346 7609529 1 rs10158341 rs12075206 61.486 0 RGS13 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 RGS13 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 RGS13 chr5: 176780545-176896412 12 115868 1 rs4131289 rs2029164 11.65 0 RGS14 chr5: 175912331-176789719 127 877389 1 rs7708363 rs6556312 23.456 0 RGS14 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 RGS14 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 RGS14 chr5: 176010125-180058963 954 4048839 1 rs936912 rs2290983 30.904 0 RGS14 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 RGS16 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 RGS16 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 RGS16 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 RGS16 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 RGS18 chr1: 186642429-197195650 1628 10553222 4 rs2206593 rs4915406 24.676 0 RGS18 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 RGS18 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 RGS18 chr1: 188735336-196495566 1363 7760231 1 rs10754227 rs6693594 68.665 0 RGS18 chr1: 188802542-196412070 1346 7609529 1 rs10158341 rs12075206 61.486 0 RGS18 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 RGS18 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 RGS18 chr1: 191640296-191788524 25 148229 1 rs10920990 rs17402518 14.942 339068 RGS18 chr20: 61008620-62751454 409 1742835 1 rs2427340 rs13039817 86.487 0 RGS19 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 RGS2 chr1: 186642429-197195650 1628 10553222 4 rs2206593 rs4915406 24.676 0 RGS2 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 RGS2 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 RGS2 chr1: 188735336-196495566 1363 7760231 1 rs10754227 rs6693594 68.665 0 RGS2 chr1: 188802542-196412070 1346 7609529 1 rs10158341 rs12075206 61.486 0 RGS2 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 RGS2 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 RGS2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 RGS4 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 RGS4 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 RGS4 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 RGS5 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 RGS5 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 RGS5 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 RGS7 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 RGS7 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 RGS7 chr3: 116881714-132034199 2802 15152486 3 rs7649284 rs3844501 21.439 0 RHO chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 RHO chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 RHO chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 RHO chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 RHO chr3: 94377411-140094984 8050 45717574 3 rs9844990 rs7618673 46.041 0 RHO chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 RHO chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 RHOA chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 RHOA chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 RHOA chr3: 46713865-52833805 488 6119941 1 rs3935248 rs3617 54.926 0 RHOA chr4: 36130920-40415109 1046 4284190 3 rs13142416 rs278933 15.979 0 RHOH chr4: 39984938-40447914 112 462977 3 rs2732072 rs7693621 203.873 0 RHOH chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 RHOH chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 RHOH chr4: 31619950-97811299 11610 66191350 1 rs6811437 rs12644209 44.41 0 RHOH chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 RHOH chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 RHOH chr11: 198510-5875867 1467 5677358 3 rs3802985 rs2045046 49.035 0 RIC8A chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 RIC8B chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 RIC8B chr12: 106912929-107229705 43 316777 1 rs741624 rs10444533 15.351 0 RIC8B chr12: 84152210-113464649 5560 29312440 1 rs10862748 rs16942470 28.181 0 RIC8B chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 RIF1 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 RIF1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 RIF1 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 RIF1 chr2: 152251363-152423605 27 172243 1 rs10173597 rs3732311 11.735 0 RIF1 chr18: 13708574-28197518 1970 14488945 4 rs4796995 rs2542754 1.046 0 RIOK3 chr18: 20856718-21719327 145 862610 1 rs6507573 rs2278664 26.842 0 RIOK3 chr6: 428722-31742590 1987 31313869 3 rs1473602 rs707928 44.729 0 RIPK1 chr6: 2681610-31453618 81 28772009 1 rs1131896 rs9267212 428.052 0 RIPK1 chr6: 2681610-31453113 80 28771504 3 rs1131896 rs2904600 359.691 0 RIPK1 chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 40.382 0 RIPK1 chr6: 1165092-29899147 56 28734056 0 rs3128864 rs2394704 57.657 0 RIPK1 chr6: 1171596-29892436 39 28720841 1 rs3128994 rs9259806 33.185 0 RIPK1 chr6: 1171596-29899147 47 28727552 0 rs3128994 rs2394704 61.991 0 RIPK1 chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 34.598 0 RIPK1 chr6: 2681610-31453618 81 28772009 3 rs1131896 rs9267212 390.234 0 RIPK1 chr6: 1171596-29892436 39 28720841 1 rs3128994 rs9259806 31.699 0 RIPK1 chr8: 83244535-93942913 1538 10698379 4 rs16910225 rs4735193 11.456 0 RIPK2 chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 RIPK2 chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 RIPK2 chr8: 90401333-90632741 36 231409 1 rs7014232 rs218921 15.433 137234 RIPK2 chr8: 84037048-138506934 11020 54469887 1 rs13265895 rs1849692 72.228 0 RIPK2 chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 RIPK2 chr8: 90475375-90608246 23 132872 1 rs1487672 rs1510470 96.299 161729 RIPK2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 RIT1 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 RIT1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 RIT1 chr18: 40409146-41694523 242 1285378 4 rs10502802 rs7226412 5.665 0 RIT2 chr18: 40324824-40488279 28 163456 1 rs612939 rs7226659 22.393 0 RIT2 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 RNF10 chr12: 112610714-133708729 5366 21098016 3 rs11066188 rs11147249 695.45 0 RNF10 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 RNF11 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 RNF11 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 RPA2 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 RPA2 chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 RPL12 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 RPL12 chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 RPL12 chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 RPL12 chr9: 130128056-130237356 24 109301 3 rs10819279 rs2250161 17.727 0 RPL12 chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 RPL37A chr2: 211013993-242051777 6871 31037785 3 rs4673499 rs2074824 40.702 0 RPL37A chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 RPL37A chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 RPL37A chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 RPL37A chr11: 766479-870446 11 103968 1 rs7937869 rs6682 15.548 0 RPLP2 chr11: 549119-1323564 100 774446 1 rs4963136 rs5743899 50.097 0 RPLP2 chr11: 589246-2866248 476 2277003 1 rs7116322 rs2237899 43.461 0 RPLP2 chr11: 356090-2201163 310 1845074 1 rs12049834 rs6578993 40.709 0 RPLP2 chr11: 198510-5875867 1467 5677358 3 rs3802985 rs2045046 49.035 0 RPLP2 chr11: 392079-3226221 734 2834143 1 rs6598025 rs10833462 79.883 0 RPLP2 chr11: 219089-1139111 206 920023 1 rs511744 rs11245979 38.286 0 RPLP2 chr20: 34817545-44483225 1946 9665681 1 rs17093449 rs6130947 4536.622 0 RPN2 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 RPS14 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 RPS14 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 RPS14 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 RPS14 chr16: 66659818-69310136 211 2650319 1 rs165207 rs153047 34.961 0 RRAD chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 RRAD chr16: 66694843-66956447 18 261605 1 rs165056 rs4783744 14.8 0 RRAD chr16: 66934153-67328453 46 394301 1 rs3843712 rs3868143 60.301 0 RRAD chr11: 198510-5875867 1467 5677358 3 rs3802985 rs2045046 49.035 0 RRM1 chr2: 54984424-67416189 2413 12431766 3 rs980644 rs12473913 14.927 0 RTN4 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 RTN4 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 RTN4 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 RTN4 chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 RTN4 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 RUVBL2 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 RUVBL2 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 RUVBL2 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 RUVBL2 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 RUVBL2 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 RUVBL2 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 RYR1 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 RYR1 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 RYR1 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 RYR1 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 RYR1 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 RYR1 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 RYR2 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 RYR2 chr1: 237310139-239159611 464 1849473 1 rs2490371 rs1915278 47.032 0 RYR2 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 RYR2 chr1: 237584925-237904870 86 319946 1 rs4593814 rs10925504 31.95 0 RYR2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 S100A6 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 S100A6 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 S100A6 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 S100A8 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 S100A8 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 S100A8 chr13: 19496434-50144613 7295 30648180 3 rs1838114 rs11148151 43.395 0 SACS chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 SARS chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 SARS chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 SARS chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 SCN8A chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 SCN8A chr2: 119935802-128867841 1515 8932040 3 rs935361 rs6747421 14.116 0 SCTR chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 SCTR chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 SCTR chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 SCTR chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 SCTR chr2: 116260745-130688292 2685 14427548 3 rs1868327 rs10928943 1170.496 0 SCTR chr2: 3994639-20951332 3904 16956694 3 rs4850016 rs619562 20.912 0 SDC1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 SDC1 chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 SDC2 chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 SDC2 chr8: 84037048-138506934 11020 54469887 1 rs13265895 rs1849692 72.228 0 SDC2 chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 SDC2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 SDC3 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 SDC3 chr20: 34817545-44483225 1946 9665681 1 rs17093449 rs6130947 4536.622 0 SDC4 chr8: 53363937-64107847 2115 10743911 3 rs284818 rs2043525 25.971 0 SDCBP chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 SDCBP chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 SDCBP chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 SDCBP chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 SDPR chr2: 185021912-195974363 1399 10952452 4 rs1526208 rs1599755 9.807 0 SDPR chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 SDPR chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 SDPR chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 SDPR chr2: 190823768-196952010 832 6128243 1 rs785567 rs6712905 35.403 0 SDPR chr2: 185221268-213136747 4656 27915480 1 rs17501385 rs2135161 31.832 0 SDPR chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 SELE chr1: 164144117-180071987 3186 15927871 3 rs12037444 rs6425606 30.846 0 SELE chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 SELE chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 SELE chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 SELENBP1 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 SELENBP1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 SELENBP1 chr20: 34817545-44483225 1946 9665681 1 rs17093449 rs6130947 4536.622 0 SEMG1 chr20: 34817545-44483225 1946 9665681 1 rs17093449 rs6130947 4536.622 0 SEMG2 chr6: 428722-31742590 1987 31313869 3 rs1473602 rs707928 44.729 0 SERPINB9 chr6: 2681610-31453618 81 28772009 1 rs1131896 rs9267212 428.052 0 SERPINB9 chr6: 2681610-31453113 80 28771504 3 rs1131896 rs2904600 359.691 0 SERPINB9 chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 40.382 0 SERPINB9 chr6: 1165092-29899147 56 28734056 0 rs3128864 rs2394704 57.657 0 SERPINB9 chr6: 1171596-29892436 39 28720841 1 rs3128994 rs9259806 33.185 0 SERPINB9 chr6: 1171596-29899147 47 28727552 0 rs3128994 rs2394704 61.991 0 SERPINB9 chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 34.598 0 SERPINB9 chr6: 2681610-31453618 81 28772009 3 rs1131896 rs9267212 390.234 0 SERPINB9 chr6: 1171596-29892436 39 28720841 1 rs3128994 rs9259806 31.699 0 SERPINB9 chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 SET chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 SET chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 SET chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 SET chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 SETD4 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 SETD4 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 SETD4 chr21: 27808458-44731138 4502 16922681 1 rs150760 rs504022 45.745 0 SETD4 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 SETD4 chr21: 37312170-45589727 2506 8277558 1 rs1573303 rs4818886 41.534 0 SETD4 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 SETD4 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 SETD4 chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 SETD4 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 SETD4 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 SETD4 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 SETD4 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 SETD4 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 SETD4 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 SETD4 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 SETDB1 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 SETDB1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 SETDB1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 SF3B14 chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 SGOL1 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 SGOL1 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 SGOL1 chr3: 20375260-20527630 39 152371 3 rs7629900 rs582714 14.963 147536 SGOL1 chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 SGOL2 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 SGOL2 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 SGOL2 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 SGOL2 chr2: 185221268-213136747 4656 27915480 1 rs17501385 rs2135161 31.832 0 SGOL2 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 SH2B3 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 SH2B3 chr12: 84152210-113464649 5560 29312440 1 rs10862748 rs16942470 28.181 0 SH2B3 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 SHANK1 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 SHANK1 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 SHANK1 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 SHANK1 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 SHANK1 chr17: 7031638-7592780 100 561143 3 rs2062737 rs2287497 12.667 0 SHBG chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 SHC1 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 SHC1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 SHC1 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 SIAH1 chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 SIRT2 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 SIRT2 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 SIRT2 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 SIRT2 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 SIRT2 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 SIRT2 chr9: 4228550-4543307 142 314758 3 rs2890551 rs2026828 140.34 0 SLC1A1 chr9: 674275-7919153 2680 7244879 3 rs11791986 rs2208742 29.482 0 SLC1A1 chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 SLC1A1 chr9: 4483912-4598699 59 114788 1 rs10814988 rs4742012 163.863 0 SLC1A1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 SLC2A1 chr1: 42204406-46534543 635 4330138 1 rs710231 rs785512 33.167 0 SLC2A1 chr1: 43380982-44438396 167 1057415 1 rs841837 rs783308 180.439 0 SLC2A1 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 SLC2A1 chr5: 1132216-9177932 2386 8045717 3 rs4594899 rs3777281 13.79 0 SLC6A3 chr5: 177264-1850563 577 1673300 1 rs6889904 rs10512644 26.987 0 SLC6A3 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 SLC6A9 chr1: 42204406-46534543 635 4330138 1 rs710231 rs785512 33.167 0 SLC6A9 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 SLC6A9 chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 SLC9A3R1 chr17: 67081830-78829375 2912 11747546 1 rs2302134 rs12943041 31.498 0 SLC9A3R1 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 SLC9A3R1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 SLC9A3R1 chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 SMAD3 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 SMAD5 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 SMAD5 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 SMAD5 chr5: 68234769-70811821 12971 2577053 4 rs6449986 rs279322 2.672 0 SMN2 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 SMN2 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 SMN2 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 SMN2 chr5: 69323596-70251701 172 928106 1 cnvi0017237 cnvi0021172 72.833 0 SMN2 chr5: 69291141-70271505 180 980365 1 cnvi0017232 cnvi0021174 79.654 0 SMN2 chr5: 69705610-70337808 119 632199 1 cnvi0017250 cnvi0017333 26.338 0 SMN2 chr5: 69291141-70464426 202 1173286 3 cnvi0017232 cnvi0021178 63.166 0 SMN2 chr5: 69369754-70271505 162 901752 3 cnvi0023216 cnvi0021174 39.93 0 SMN2 chr5: 69706727-70439171 128 732445 3 cnvi0021138 cnvi0017348 74.882 0 SMN2 chr5: 69342745-70251701 165 908957 1 cnvi0023213 cnvi0021172 48.005 0 SMN2 chr5: 69328641-70291250 177 962610 1 cnvi0023210 cnvi0017323 79.015 0 SMN2 chr5: 68835256-70379466 254 1544211 1 cnvi0017190 cnvi0023557 59.724 0 SMN2 chr5: 68835256-69758416 154 923161 3 cnvi0017190 cnvi0023229 44.384 0 SMN2 chr5: 69094990-69705827 97 610838 3 cnvi0017228 cnvi0021137 23.396 0 SMN2 chr5: 69328641-70356098 184 1027458 1 cnvi0023210 cnvi0017340 96.892 0 SMN2 chr5: 69962181-70464426 71 502246 3 cnvi0017271 cnvi0021178 35.476 0 SMN2 chr5: 69688350-70379466 126 691117 3 cnvi0017249 cnvi0023557 19.03 0 SMN2 chr5: 68835256-70379466 254 1544211 1 cnvi0017190 cnvi0023557 30.266 0 SMN2 chr5: 68885670-70081434 201 1195765 3 cnvi0017212 cnvi0023238 103.915 0 SMN2 chr5: 69323596-70251701 172 928106 1 cnvi0017237 cnvi0021172 78.003 0 SMN2 chr5: 69283377-70488200 209 1204824 1 cnvi0023548 cnvi0021181 92.755 0 SMN2 chr5: 69323596-70251701 172 928106 1 cnvi0017237 cnvi0021172 55.208 0 SMN2 chr5: 68885670-70081434 201 1195765 4 cnvi0017212 cnvi0023238 5.263 0 SMN2 chr5: 69656454-70379466 130 723013 3 cnvi0017310 cnvi0023557 59.497 0 SMN2 chr5: 69243138-69709774 89 466637 3 cnvi0023208 cnvi0021141 42.409 0 SMN2 chr5: 68885670-69806822 162 921153 3 cnvi0017212 cnvi0023235 39.551 0 SMN2 chr5: 69174834-70316072 201 1141239 3 cnvi0017202 cnvi0017347 68.316 0 SMN2 chr5: 70209502-70356098 25 146597 3 cnvi0017295 cnvi0017340 12.419 0 SMN2 chr5: 69283377-70251701 177 968325 1 cnvi0023548 cnvi0021172 74.445 0 SMN2 chr5: 69323596-70251701 172 928106 1 cnvi0017237 cnvi0021172 60.349 0 SMN2 chr5: 69634915-70439171 139 804257 3 cnvi0017313 cnvi0017348 117.085 0 SMN2 chr5: 69283377-70275720 182 992344 1 cnvi0023548 cnvi0017327 61.378 0 SMN2 chr5: 69291141-70251701 176 960561 1 cnvi0017232 cnvi0021172 77.51 0 SMN2 chr5: 69243138-70291250 191 1048113 1 cnvi0023208 cnvi0017323 71.423 0 SMN2 chr5: 69291141-70251701 176 960561 1 cnvi0017232 cnvi0021172 64.951 0 SMN2 chr5: 68995989-70072721 183 1076733 3 cnvi0017222 cnvi0021154 79.331 0 SMN2 chr5: 69323596-69737299 84 413704 3 cnvi0017237 cnvi0017254 35.683 0 SMN2 chr5: 69291141-70291250 182 1000110 1 cnvi0017232 cnvi0017323 44.087 0 SMN2 chr5: 68835256-70450158 262 1614903 3 cnvi0017190 cnvi0017349 49.942 0 SMN2 chr5: 69440806-70593467 185 1152662 1 cnvi0017247 cnvi0026040 53.84 0 SMN2 chr5: 69291141-70369397 190 1078257 1 cnvi0017232 cnvi0018714 76.309 0 SMN2 chr5: 69291141-70291250 182 1000110 1 cnvi0017232 cnvi0017323 79.105 0 SMN2 chr16: 66659818-69310136 211 2650319 1 rs165207 rs153047 34.961 0 SMPD3 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 SMPD3 chr15: 40561890-65059651 4763 24497762 1 rs6492939 rs1008917 60.034 0 SNAP23 chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 SNAP23 chr20: 6111569-21985498 4344 15873930 3 rs6038366 rs6047798 43.161 0 SNAP25 chr6: 76922913-86913307 1793 9990395 4 rs2314204 rs9359686 7.874 0 SNAP91 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 SNAP91 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 SNAP91 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 SNAP91 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 SNAP91 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 SNAP91 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 SNAP91 chr6: 69745723-124631456 10981 54885734 1 rs2225803 rs932600 38.287 0 SNAP91 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 SNAP91 chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 SNAP91 chr4: 88117272-90765280 562 2648009 3 rs6531956 rs1372522 17.723 0 SNCA chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 SNCA chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 SNCA chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 SNCA chr4: 31619950-97811299 11610 66191350 1 rs6811437 rs12644209 44.41 0 SNCA chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 SNCA chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 SNCA chr20: 6111569-21985498 4344 15873930 3 rs6038366 rs6047798 43.161 0 SNRPB2 chr15: 23648792-28535266 1130 4886475 1 rs1830115 rs1635168 3371.453 0 SNURF chr15: 24991944-36734986 2650 11743043 3 rs11161135 rs2444757 14.503 0 SNURF chr15: 20161372-30439396 1944 10278025 4 rs6599770 cnvi0020349 10.79 0 SNURF chr15: 23620859-28535266 1249 4914408 1 cnvi0016424 rs1635168 421.588 0 SNURF chr15: 20058438-32544679 2394 12486242 3 rs12591240 cnvi0018163 296.82 0 SNURF chr15: 23648792-28535266 1130 4886475 1 rs1830115 rs1635168 2494.885 0 SNURF chr18: 63017137-71284888 2142 8267752 1 rs12966197 rs1107827 34.629 0 SOCS6 chr18: 63733025-69401985 1543 5668961 1 rs2715290 rs993816 45.936 0 SOCS6 chr18: 67544717-69365932 428 1821216 3 rs1788244 rs1394981 461.753 0 SOCS6 chr18: 62041997-76047493 3846 14005497 1 rs1421538 rs8085865 33.212 0 SOCS6 chr17: 35814383-36784639 134 970257 1 rs853231 rs7220099 43.224 0 SOCS7 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 SOCS7 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 SOCS7 chr15: 40561890-65059651 4763 24497762 1 rs6492939 rs1008917 60.034 0 SORD chr15: 33816995-95345594 12571 61528600 1 rs4281677 rs965551 31.276 0 SORD chr6: 428722-31742590 1987 31313869 3 rs1473602 rs707928 44.729 0 SOX4 chr6: 19044000-31286381 6774 12242382 1 rs6922929 rs9265057 31.6 0 SOX4 chr6: 2681610-31453618 81 28772009 1 rs1131896 rs9267212 428.052 0 SOX4 chr6: 3764851-31298743 7861 27533893 3 rs28880026 rs28752863 40.215 0 SOX4 chr6: 3772684-31298743 7858 27526060 3 rs12661707 rs28752863 27.127 0 SOX4 chr6: 2681610-31453113 80 28771504 3 rs1131896 rs2904600 359.691 0 SOX4 chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 40.382 0 SOX4 chr6: 1165092-29899147 56 28734056 0 rs3128864 rs2394704 57.657 0 SOX4 chr6: 1171596-29892436 39 28720841 1 rs3128994 rs9259806 33.185 0 SOX4 chr6: 11677538-31289284 4992 19611747 1 rs2022016 rs9265170 68.97 0 SOX4 chr6: 1171596-29899147 47 28727552 0 rs3128994 rs2394704 61.991 0 SOX4 chr6: 19812444-31286381 6951 11473938 1 rs16882740 rs9265057 32.473 0 SOX4 chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 34.598 0 SOX4 chr6: 2681610-31453618 81 28772009 3 rs1131896 rs9267212 390.234 0 SOX4 chr6: 1171596-29892436 39 28720841 1 rs3128994 rs9259806 31.699 0 SOX4 chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 SPAG1 chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 SPAG1 chr8: 84037048-138506934 11020 54469887 1 rs13265895 rs1849692 72.228 0 SPAG1 chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 SPAG1 chr16: 88475508-89789898 208 1314391 1 rs8044502 rs6500437 39.403 0 SPG7 chr16: 89157547-89875710 92 718164 1 rs4782474 rs11861084 32.421 0 SPG7 chr16: 88154644-90088437 279 1933794 4 rs9924813 rs2241039 0 0 SPG7 chr4: 88117272-90765280 562 2648009 3 rs6531956 rs1372522 17.723 0 SPP1 chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 SPP1 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 SPP1 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 SPP1 chr4: 31619950-97811299 11610 66191350 1 rs6811437 rs12644209 44.41 0 SPP1 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 SPP1 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 SPP1 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 SPTBN1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 SPTBN1 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 SPTBN1 chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 SPTBN1 chr5: 179193598-180016644 167 823047 1 rs3797776 rs368686 50.157 0 SQSTM1 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 SQSTM1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 SQSTM1 chr5: 176010125-180058963 954 4048839 1 rs936912 rs2290983 30.904 0 SQSTM1 chr20: 34817545-44483225 1946 9665681 1 rs17093449 rs6130947 4536.622 0 SRC chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 SRGAP3 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 SRGAP3 chr13: 19496434-50144613 7295 30648180 3 rs1838114 rs11148151 43.395 0 STARD13 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 STC2 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 STC2 chr12: 11740163-33217793 5315 21477631 3 rs10491981 rs12424662 69.717 0 STRAP chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 STRAP chr2: 34687910-41885773 1679 7197864 4 rs2887973 rs6748566 14.365 0 STRN chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 STRN chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 STRN4 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 STRN4 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 STRN4 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 STRN4 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 STRN4 chr19: 43306156-53249347 7320 9943192 3 rs10412335 rs7249213 39.272 0 STRN4 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 STX12 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 STX12 chr16: 28301487-31147548 157 2846062 1 rs9939450 rs2855475 36.755 0 STX4 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 STX4 chr16: 29130999-33612830 601 4481832 3 rs12922496 rs2067108 21.218 0 STX4 chr16: 28642242-33612830 684 4970589 4 rs34954049 rs2067108 4.025 0 STX4 chr11: 60589137-64068310 499 3479174 1 rs656736 rs2286614 53.467 0 STX5 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 STX5 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 STX5 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 STX5 chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 STXBP1 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 STXBP1 chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 STXBP1 chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 STXBP1 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 STXBP3 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 STXBP3 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 STXBP3 chr4: 58593206-71053262 1785 12460057 4 rs574630 rs926004 35.7 0 SULT1E1 chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 SULT1E1 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 SULT1E1 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 SULT1E1 chr4: 31619950-97811299 11610 66191350 1 rs6811437 rs12644209 44.41 0 SULT1E1 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 SULT1E1 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 SULT1E1 chr6: 146892943-169478886 6121 22585944 3 rs12199886 rs13219463 43.565 0 SUMO4 chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 SUMO4 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 SUMO4 chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 SUMO4 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 SUMO4 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 SUMO4 chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 SUMO4 chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 SYK chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 SYK chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 SYK chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 SYK chr12: 76374448-83556258 1351 7181811 3 rs7976486 rs4394896 27.448 0 SYT1 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 SYT1 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 SYT1 chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 TANC1 chr2: 157783439-161524149 699 3740711 3 rs10933271 rs11679483 15.656 0 TANC1 chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 TANC1 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 TANC1 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 TANC1 chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 TANK chr2: 161861513-161991197 36 129685 1 rs7579574 rs17705608 19.022 2269 TANK chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 TANK chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 TANK chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 TANK chr2: 161901301-162018643 25 117343 1 rs4664395 rs1267059 21.357 0 TANK chr16: 28301487-31147548 157 2846062 1 rs9939450 rs2855475 36.755 0 TAOK2 chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 TAOK2 chr16: 29130999-33612830 601 4481832 3 rs12922496 rs2067108 21.218 0 TAOK2 chr16: 28642242-33612830 684 4970589 4 rs34954049 rs2067108 4.025 0 TAOK2 chr5: 73958245-81276023 1632 7317779 3 rs4703640 rs4703863 22.731 0 TBCA chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 TBCA chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 TBCA chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 TBCA chr5: 76450190-79622472 726 3172283 1 rs6864250 rs2405378 35.823 0 TBCA chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 TBCD chr17: 79150654-81047708 15608 1897055 1 rs12103867 rs35680231 31.668 0 TBCD chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 TBCE chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 TBCE chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 TBCE chr12: 62261443-72745898 2376 10484456 3 rs3759288 rs2044305 73.366 0 TBK1 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 TBK1 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 TBK1 chr12: 63939740-69842643 1240 5902904 3 rs513203 rs6581895 22.639 0 TBK1 chr19: 1961474-14570703 2131 12609230 1 rs2041120 rs12974686 29.276 0 TBXA2R chr19: 3053574-18061509 2612 15007936 3 rs7938 rs7250332 73.169 0 TBXA2R chr19: 384644-4514135 854 4129492 1 rs12151104 rs4807598 56.902 0 TBXA2R chr19: 1505874-1917925 58 412052 1 rs197198 rs10410479 12.119 0 TCF3 chr19: 1505874-2123516 98 617643 1 rs197198 rs2072304 26.337 0 TCF3 chr19: 266034-2771641 432 2505608 4 rs2312724 rs741103 15.34 0 TCF3 chr19: 1572369-3354956 351 1782588 1 rs10415156 rs4807451 45.225 0 TCF3 chr19: 384644-4514135 854 4129492 1 rs12151104 rs4807598 56.902 0 TCF3 chr19: 1351916-1716865 58 364950 1 rs11670805 rs11878765 31.586 0 TCF3 chr18: 50178168-53168243 510 2990076 4 rs10853620 rs3017183 5.363 0 TCF4 chr18: 46577218-63087976 3720 16510759 1 rs357893 rs487555 37.146 0 TCF4 chr6: 146892943-169478886 6121 22585944 3 rs12199886 rs13219463 43.565 0 TCP1 chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 TCP1 chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 TCP1 chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 TCP1 chr6: 113398162-170729060 13630 57330899 3 rs10457255 rs7739284 70.234 0 TCP1 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 TDGF1 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 TDGF1 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 TDGF1 chr6: 29877864-35562640 12719 5684777 3 rs28592582 rs3798346 61.622 0 TEAD3 chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 TEAD3 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 TEAD3 chr14: 20578244-21484086 297 905843 1 rs3939209 rs1263871 40.7 0 TEP1 chr5: 306032-1392721 159 1086690 1 rs7723693 rs10064525 37.172 0 TERT chr5: 1132216-9177932 2386 8045717 3 rs4594899 rs3777281 13.79 0 TERT chr5: 177264-1850563 577 1673300 1 rs6889904 rs10512644 26.987 0 TERT chr10: 52338100-60396065 1797 8057966 4 rs10508930 rs920259 44.979 0 TFAM chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 TFAM chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 TFAM chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 TGFA chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 TGFA chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 TGFA chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 TGFA chr20: 34817545-44483225 1946 9665681 1 rs17093449 rs6130947 4536.622 0 TGM2 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 928.72 0 TIAM1 chr21: 14807136-48084989 8188 33277854 3 rs459902 rs2839378 6822.044 0 TIAM1 chr21: 14640400-48084989 8195 33444590 3 rs2260810 rs2839378 4097.117 0 TIAM1 chr21: 27808458-44731138 4502 16922681 1 rs150760 rs504022 45.745 0 TIAM1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 10396.854 0 TIAM1 chr21: 14630588-48084989 8777 33454402 3 rs2261645 rs2839378 1506.856 0 TIAM1 chr21: 28203478-48084989 5467 19881512 3 rs190145 rs2839378 2230.84 0 TIAM1 chr21: 10708231-48084989 8844 37376759 3 rs4044122 rs2839378 454.543 0 TIAM1 chr21: 14569317-48084989 8782 33515673 3 rs1772304 rs2839378 967.362 0 TIAM1 chr21: 14630588-48068728 8772 33438141 3 rs2261645 rs2245760 588.932 0 TIAM1 chr21: 14768343-48084989 8193 33316647 3 rs2257224 rs2839378 5021.076 0 TIAM1 chr21: 14601415-48084989 8249 33483575 3 rs2775537 rs2839378 4787.438 0 TIAM1 chr21: 14595264-48084989 8781 33489726 3 rs2847443 rs2839378 1871.363 0 TIAM1 chr21: 14377880-48050388 8805 33672509 3 rs3875547 rs2839367 163.872 0 TIAM1 chr15: 24991944-36734986 2650 11743043 3 rs11161135 rs2444757 14.503 0 TJP1 chr15: 27740007-30366247 464 2626241 1 rs6497213 rs10152753 44.251 0 TJP1 chr15: 20161372-30439396 1944 10278025 4 rs6599770 cnvi0020349 10.79 0 TJP1 chr15: 20058438-32544679 2394 12486242 3 rs12591240 cnvi0018163 296.82 0 TJP1 chr17: 74204592-79532654 1324 5328063 1 rs4505373 rs3934711 38.57 0 TK1 chr17: 63495631-81041077 3846 17545447 3 rs9892932 rs6502043 45.127 0 TK1 chr17: 67081830-78829375 2912 11747546 1 rs2302134 rs12943041 31.498 0 TK1 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 TK1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 TK1 chr4: 36130920-40415109 1046 4284190 3 rs13142416 rs278933 15.979 0 TLR10 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 TLR10 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 TLR10 chr4: 31619950-97811299 11610 66191350 1 rs6811437 rs12644209 44.41 0 TLR10 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 TLR10 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 TLR10 chr3: 147200492-151900719 955 4700228 3 rs9876193 rs325713 20.467 0 TM4SF1 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 TM4SF1 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 TM4SF1 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 TM4SF1 chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 TM4SF1 chr1: 1310924-2756621 137 1445698 4 rs2765033 rs4648384 8.675 0 TNFRSF14 chr1: 2373089-2883932 59 510844 1 rs6659405 rs2485945 28.34 0 TNFRSF14 chr1: 949468-3587505 498 2638038 1 rs1126625 rs3765696 23.726 0 TNFRSF14 chr1: 1254841-3342804 386 2087964 1 rs10907179 rs870171 39.259 0 TNFRSF14 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 TNFRSF1A chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 TNFRSF1B chr1: 12217852-12420300 30 202449 1 rs1148459 rs6660347 12.94 0 TNFRSF1B chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 TNFRSF1B chr3: 160836006-176261513 2782 15425508 4 rs1599389 rs1377820 17.004 0 TNIK chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 TNIK chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 TNIK chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 TNIK chr3: 161695760-196993693 7208 35297934 1 rs4575917 rs406284 54.788 0 TNIK chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 TNIK chr4: 1224811-7063524 1270 5838714 1 rs4974574 rs6836129 27.935 0 TNIP2 chr4: 415311-15136380 3262 14721070 3 rs7695712 rs2702525 10.287 0 TNIP2 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 TNIP2 chr11: 589246-2866248 476 2277003 1 rs7116322 rs2237899 43.461 0 TNNI2 chr11: 356090-2201163 310 1845074 1 rs12049834 rs6578993 40.709 0 TNNI2 chr11: 198510-5875867 1467 5677358 3 rs3802985 rs2045046 49.035 0 TNNI2 chr11: 392079-3226221 734 2834143 1 rs6598025 rs10833462 79.883 0 TNNI2 chr19: 54743217-58326001 842 3582785 3 rs17239607 rs2303817 41.312 0 TNNI3 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 TNNI3 chr19: 55590671-55994156 87 403486 1 rs1671163 cnvi0009418 33.877 0 TNNI3 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 TNNT2 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 TNNT2 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 TNNT2 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 TNNT2 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 TNNT2 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 TNNT2 chr1: 198152759-247886615 10843 49733857 3 rs10922372 rs11809582 60.483 0 TOMM20 chr1: 185675592-243641420 11724 57965829 1 rs4651286 rs2994339 31.238 0 TOMM20 chr1: 174219398-247422297 15986 73202900 1 rs16846809 rs4642922 35.258 0 TOMM20 chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 TOP2A chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 TOP2A chr17: 7031638-7592780 100 561143 3 rs2062737 rs2287497 12.667 0 TP53 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 TPI1 chr16: 66659818-69310136 211 2650319 1 rs165207 rs153047 34.961 0 TRADD chr16: 15642809-85927814 11706 70285006 1 rs4781673 rs391023 26.575 0 TRADD chr16: 66934153-67328453 46 394301 1 rs3843712 rs3868143 60.301 0 TRADD chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 TRAF1 chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 TRAF1 chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 TRAF1 chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 TRAF1 chr9: 138961722-140376668 138 1414947 1 rs11103306 rs10116708 35.913 0 TRAF2 chr9: 137718113-139841512 539 2123400 4 rs4842173 rs884113 1.053 0 TRAF2 chr9: 138873600-140938183 302 2064584 1 cnvi0002612 rs3750506 26.611 0 TRAF2 chr9: 139492789-140212642 109 719854 1 rs28485548 rs13295516 79.502 0 TRAF2 chr11: 23155251-39227743 3093 16072493 4 rs12421611 rs901947 29.569 0 TRAF6 chr4: 149196991-157601193 1461 8404203 3 rs6812904 rs10030015 30.798 0 TRIM2 chr4: 125165157-188223037 11572 63057881 3 rs6854804 rs9993067 11.06 0 TRIM2 chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 TRIM2 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 TRIM2 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 TRIM2 chr4: 126959315-183880263 10103 56920949 3 rs9985873 rs2714510 50.565 0 TRIM2 chr4: 148566463-156666845 1395 8100383 1 rs17475359 rs6814688 54.297 0 TRIM2 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 TRIM2 chr11: 114191016-134258416 5073 20067401 3 rs2847476 rs893951 4.233 0 TRIM29 chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 TRIM29 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 TRIM29 chr5: 14445585-14563425 24 117841 1 rs27114 rs17307347 33.354 0 TRIO chr5: 6100526-29461973 4878 23361448 3 rs307186 rs16898985 13.817 0 TRIO chr5: 13798559-14174106 121 375548 3 rs795544 rs32571 239.534 0 TRIO chr11: 46466828-132142789 15847 85675962 1 rs2171668 rs3133885 44.46 0 TRMT112 chr11: 47380593-117549808 12162 70169216 3 rs3740689 rs7926736 11.877 0 TRMT112 chr11: 61454190-134278387 16442 72824198 1 rs4963307 cnvi0005398 65.765 0 TRMT112 chr3: 141691407-146997009 977 5305603 4 rs3804771 rs7645827 19.643 0 TRPC1 chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 TRPC1 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 TRPC1 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 TRPC1 chr3: 77517611-186461181 18091 108943571 1 rs4684011 rs2062632 39.712 0 TRPC1 chr3: 90389747-175907342 21070 85517596 1 rs2316813 rs2067613 41.412 0 TRPC1 chr4: 115638209-146509970 4922 30871762 4 rs4269197 rs1874572 7.614 0 TRPC3 chr4: 62883431-188650233 21726 125766803 1 rs1510920 rs7438821 38.998 0 TRPC3 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 TRPC3 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 TRPC3 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 TRPC3 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 TRPC3 chr13: 19496434-50144613 7295 30648180 3 rs1838114 rs11148151 43.395 0 TRPC4 chr13: 34752890-109100024 15589 74347135 1 rs2321822 rs7332707 33.721 0 TRPC4 chr17: 3439454-3555424 40 115971 1 rs401643 rs4790530 19.479 0 TRPV1 chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 TRPV4 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 TRPV4 chr12: 84152210-113464649 5560 29312440 1 rs10862748 rs16942470 28.181 0 TRPV4 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 TRPV6 chr7: 117831743-152070158 6055 34238416 3 rs3808178 rs6966258 7.28 0 TRPV6 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 TRPV6 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 TRPV6 chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 TRPV6 chr7: 99940307-100119643 15 179337 3 rs13228694 rs1962151 3.843 0 TSC22D4 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 TSC22D4 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 TSC22D4 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 TSC22D4 chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 TSC22D4 chr14: 26395832-94937043 14253 68541212 1 rs6574718 rs11160183 32.364 0 TSHR chr14: 58168761-107287663 10395 49118903 1 rs7160495 rs10149476 28.336 0 TSHR chr14: 41670102-105695446 14439 64025345 1 rs1778370 rs2018404 40.094 0 TSHR chr6: 41773322-45545975 754 3772654 3 rs2153878 rs7764616 22.895 0 TTBK1 chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 TTBK1 chr6: 32519005-69242020 15177 36723016 3 rs28490179 rs10498868 27.622 0 TTBK1 chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 TTBK1 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 TTC1 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 TTC1 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 TTC1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 TTC1 chr6: 76922913-86913307 1793 9990395 4 rs2314204 rs9359686 7.874 0 TTK chr6: 46580034-153045913 19775 106465880 1 rs3799873 rs1282451 31.858 0 TTK chr6: 78523761-168944598 18867 90420838 1 rs7756601 rs2180346 43.616 0 TTK chr6: 78391867-152688010 14635 74296144 1 rs2504317 rs3822992 41.775 0 TTK chr6: 69900102-165298477 19424 95398376 1 rs779484 rs1511063 38.802 0 TTK chr6: 38084569-149099378 20508 111014810 3 rs2295791 rs6570897 2.249 0 TTK chr6: 62677210-165045334 21972 102368125 1 rs1212293 rs727811 36.819 0 TTK chr6: 69745723-124631456 10981 54885734 1 rs2225803 rs932600 38.287 0 TTK chr6: 32512164-129479522 27169 96967359 3 rs28495356 rs3734387 20.323 0 TTK chr6: 67621368-147709180 16188 80087813 1 rs6919455 rs7739314 52.498 0 TTK chr2: 127817546-239024180 20150 111206635 1 rs880436 rs3948117 18.946 0 TTN chr2: 179650954-181066567 391 1415614 4 rs6715901 rs10497562 1.916 0 TTN chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 TTN chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 TTN chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 TTN chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 TUBA1A chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 TUBA1A chr12: 5063897-113724945 20966 108661049 1 rs16933924 rs2241544 34.209 0 TUBA1B chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 TUBA1B chr22: 17394989-22573637 1104 5178649 3 rs1860945 rs12159423 32.25 0 TUBA8 chr6: 428722-31742590 1987 31313869 3 rs1473602 rs707928 44.729 0 TUBB chr6: 19044000-31286381 6774 12242382 1 rs6922929 rs9265057 31.6 0 TUBB chr6: 2681610-31453618 81 28772009 1 rs1131896 rs9267212 428.052 0 TUBB chr6: 3764851-31298743 7861 27533893 3 rs28880026 rs28752863 40.215 0 TUBB chr6: 3772684-31298743 7858 27526060 3 rs12661707 rs28752863 27.127 0 TUBB chr6: 29877864-35562640 12719 5684777 3 rs28592582 rs3798346 61.622 0 TUBB chr6: 2681610-31453113 80 28771504 3 rs1131896 rs2904600 359.691 0 TUBB chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 40.382 0 TUBB chr6: 11677538-31289284 4992 19611747 1 rs2022016 rs9265170 68.97 0 TUBB chr6: 29864203-31294687 11756 1430485 3 rs9259437 rs28752836 6.497 0 TUBB chr6: 19812444-31286381 6951 11473938 1 rs16882740 rs9265057 32.473 0 TUBB chr6: 26430981-31878433 8001 5447453 1 rs2893848 rs519417 55.651 0 TUBB chr6: 2584569-31286381 8 28701813 1 rs9391764 rs9265057 34.598 0 TUBB chr6: 2681610-31453618 81 28772009 3 rs1131896 rs9267212 390.234 0 TUBB chr17: 32788444-78765219 8212 45976776 1 rs11658989 rs4969429 44.819 0 TUBG1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 TUBG1 chr9: 34957613-136876021 15438 101918409 1 rs7031962 rs441233 20.716 0 TXN chr9: 27529316-137397609 17356 109868294 3 rs903603 rs7858838 79.074 0 TXN chr9: 10087429-138560311 22790 128472883 1 rs10809027 rs514157 31.6 0 TXN chr9: 1399761-136852891 25442 135453131 1 rs12341621 rs2789864 36.66 0 TXN chr18: 112535-3081210 758 2968676 1 rs9284390 rs7244954 2389.768 0 TYMS chr8: 48858933-49031831 11 172899 1 rs4873772 rs4873779 14.631 0 UBE2V2 chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 UBE2V2 chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 UBE2V2 chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 UBE2V2 chr1: 9218721-228139672 34932 218920952 1 rs12119878 rs849901 32.872 0 UBQLN4 chr1: 84434425-230410162 22096 145975738 1 rs12759527 rs12091838 28.514 0 UBQLN4 chr1: 5870534-228529606 40305 222659073 1 rs6701947 rs4653549 31.092 0 UBQLN4 chr4: 23488892-180661580 26105 157172689 1 rs12505641 rs1380000 46.38 0 UCHL1 chr4: 28602089-187390861 26883 158788773 1 rs16880825 rs1376534 32.409 0 UCHL1 chr4: 31619950-97811299 11610 66191350 1 rs6811437 rs12644209 44.41 0 UCHL1 chr4: 964359-151887280 28295 150922922 1 rs11248060 rs6839352 40.036 0 UCHL1 chr4: 28932131-179932861 26946 151000731 1 rs2222357 rs13151036 29.638 0 UCHL1 chr12: 46575008-133037139 17239 86462132 1 rs7301594 rs4883593 56.192 0 ULK1 chr12: 132378017-133182408 142 804392 1 rs11246867 rs11146967 96.002 0 ULK1 chr12: 112610714-133708729 5366 21098016 3 rs11066188 rs11147249 695.45 0 ULK1 chr19: 1961474-14570703 2131 12609230 1 rs2041120 rs12974686 29.276 0 VAV1 chr19: 3053574-18061509 2612 15007936 3 rs7938 rs7250332 73.169 0 VAV1 chr10: 71527469-135284115 13802 63756647 3 rs2255406 rs6537607 99.833 0 VCL chr10: 61696682-130205245 14577 68508564 1 rs3099371 rs2387858 33.074 0 VCL chr10: 19783593-133482605 22847 113699013 1 rs10827500 rs7096432 50.801 0 VCL chr10: 33340331-123920784 17036 90580454 1 rs10430560 rs1885516 36.263 0 VCL chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 VDAC1 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 VDAC1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 VDAC1 chr3: 1014408-30488348 7729 29473941 3 rs4234578 rs4325953 57.426 0 VHL chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 VHL chr3: 9972493-10372840 66 400348 1 rs279545 rs26310 30.958 0 VHL chr10: 5591025-21296519 4896 15705495 3 rs4881475 rs599087 67.715 0 VIM chr3: 15259461-197526201 33195 182266741 1 rs17539401 rs841672 36.501 0 VIPR1 chr3: 1079024-145525989 27876 144446966 1 rs7631088 rs7643638 39.631 0 VIPR1 chr3: 39601272-188941449 26376 149340178 1 rs6773938 rs16864111 55.996 0 VIPR1 chr17: 21685812-79278810 15514 57592999 1 rs34864328 rs2048058 24.024 0 VTN chr19: 32996606-51148772 2824 18152167 3 rs358539 rs11665802 30.671 0 WDR62 chr19: 9150838-55326739 1673 46175902 3 rs6511838 rs581623 40.349 0 WDR62 chr19: 34332765-58689834 4387 24357070 1 rs1006359 rs1483651 34.988 0 WDR62 chr19: 21535707-45414451 3108 23878745 3 rs7258086 rs439401 7.911 0 WDR62 chr19: 15763248-53249347 3050 37486100 3 rs2733749 rs7249213 77.958 0 WDR62 chr19: 15780747-55294329 3059 39513583 3 rs7255963 rs2569676 23.777 0 WDR62 chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 WDR91 chr7: 117831743-152070158 6055 34238416 3 rs3808178 rs6966258 7.28 0 WDR91 chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 WDR91 chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 WDR91 chr7: 83381032-152058141 13207 68677110 1 rs2371877 rs10226650 32.73 0 WDR91 chr5: 146510911-179954615 7510 33443705 3 rs2913319 rs10059433 22.301 0 WWC1 chr5: 42269665-169529932 23087 127260268 3 rs7445668 rs7729998 12.971 0 WWC1 chr5: 39637565-169578418 23589 129940854 1 rs6451438 rs889005 49.311 0 WWC1 chr5: 59802783-180140115 22884 120337333 1 rs35386 rs13181141 83.891 0 WWC1 chr20: 39998520-43592248 934 3593729 1 rs6072353 rs2868218 29.278 0 YWHAB chr20: 34817545-44483225 1946 9665681 1 rs17093449 rs6130947 4536.622 0 YWHAB chr17: 836541-1550106 166 713566 3 rs8081951 rs2293067 11.382 0 YWHAE chr17: 909653-1660801 210 751149 1 rs2241931 rs8075977 37.209 0 YWHAE chr7: 43927792-150707488 16960 106779697 1 rs2730617 rs743507 33.628 0 YWHAG chr7: 73178435-89984409 2908 16805975 4 rs11764572 rs42664 0.17 0 YWHAG chr7: 12434771-156664783 26767 144230013 1 rs848004 rs6968944 46.858 0 YWHAG chr7: 23139940-150669057 22249 127529118 1 rs10235786 rs3807372 33.615 0 YWHAG chr7: 75337644-77143217 201 1805574 1 rs10954377 rs6976567 29.447 0 YWHAG chr2: 3994639-20951332 3904 16956694 3 rs4850016 rs619562 20.912 0 YWHAQ chr8: 41983076-145081248 19334 103098173 1 rs12544318 rs6420181 26.491 0 YWHAZ chr8: 6879803-142673805 27751 135794003 1 rs7825750 rs2029940 24.717 0 YWHAZ chr8: 84037048-138506934 11020 54469887 1 rs13265895 rs1849692 72.228 0 YWHAZ chr8: 13273425-145668443 26660 132395019 3 rs7822301 rs760477 7.522 0 YWHAZ chr2: 39008949-239684289 36108 200675341 1 rs1056104 rs9711993 41.774 0 ZAP70 chr2: 12809411-237832366 41200 225022956 1 rs10490548 rs10929201 46.737 0 ZAP70 chr2: 52785456-238635137 32375 185849682 1 rs6545286 rs10177762 35.172 0 ZAP70 chr2: 38328178-128536280 15926 90208103 1 rs232542 rs7608627 30.628 0 ZAP70

Example 3. Treatment with Fasoracetam Monohydrate (NFC-1) of ADHD Patients with CNVs in mGluR Network Genes and Impact on Conduct Disorder

An open-label Phase Ib clinical trial was conducted to investigate the safety, pharmacokinetics and efficacy of NFC-1 (fasoracetam monohydrate) in adolescent subjects between the ages of 12 and 17 previously diagnosed with ADHD who also had at least one genetic alteration in an mGluR network gene.

The study included 30 ADHD subjects who were between ages 12 and 17, of any ancestry or race, of weight within the 5th to 95th percentile for their age, and otherwise judged to be in good medical health. Subjects were genotyped and included in the trial if they possess at least one genetic alteration in the form of at least one copy number variation (deletion or duplication) in an mGluR network gene that potentially disrupts the function of the gene. Seventeen of the 30 subjects have a CNV in a tier 1 mGluR network gene, while 7 subjects have a CNV in a tier 2 gene and 6 in a tier 3 gene. At enrollment, several trial subjects showed evidence of co-morbid phenotypes, including two subjects having recurrent tics.

Exclusion criteria comprised subjects suffering from a clinically significant illness, either mental or physical, that, in the investigator's opinion, might confound the results of the study or that might prevent them from completing the study, subjects that are pregnant or nursing, subjects that test positive for illicit drugs of that have a history of drug abuse, subjects that consume alcoholic beverages, or subjects for which the investigator is otherwise concerned regarding their compliance or suitability.

NFC-1 capsules of either 50 mg or 200 mg comprising fasoracetam monohydrate as active ingredient and placebo capsules comprising microcellulose were used for the study. The design of the trial was a phone screening (1 day), enrollment phase (1 to 2 days), a wash-out phase for subjects currently on ADHD medications (1-14 days), pharmacokinetic (PK) assessment (2 days), followed by a dose-escalation phase (35 days) and a follow-up phone visit approximately four weeks after the last dose, for a maximum of 127 days. All ADHD medications were discontinued during the wash-out phase prior to the study. The wash-out period for stimulants was 2-3 days and that for atomoxetine or noradrenergic agonists was 10-12 days. No new ADHD medications were started during the study.

A dose-escalation phase of the trial ran over a 5-week period, after the initial wash-out period and the PK and initial safety assessments. During week 1, all subjects were administered placebo capsules twice daily. After one week of placebo treatment, patients were started on 50 mg bid NFC-1 for 1 week. If safety and responsiveness data from prior dose level of fasoracetam indicated it was appropriate, subjects were then escalated to the next higher dose (100, 200, or 400 mg). Subjects who showed tolerance to the 50 mg bid dose as well as response to the drug were to be maintained at that level for the remaining 3 weeks of the trial.

Subjects who showed tolerance but lack of response or partial response to the 50 mg bid dose were to be moved up to the next higher dose of 100 mg during the following week. Subjects who showed tolerance at 100 mg but lack of response or partial response were to be moved up to the 200 mg dose the following week while those who showed both tolerance and response at 100 mg were to be kept at 100 mg bid for the remainder of the trial. Similarly, subjects moved up to the 200 mg dose who showed both tolerance and response were to be kept at 200 mg for the final week of the trial while those showing tolerance but lack of response or partial response were moved to a 400 mg dose for the final week. Of the 30 trial subjects, 3 received a maximum dose of 100 mg, 9 received a maximum dose of 200 mg, and the remaining 18 received a maximum dose of 400 mg.

While this study was not specifically directed at conduct disorder symptoms, two study subjects met the behavioral criteria for conduct disorder, with a score of 2 or 3 on at least two of the 14 Vanderbilt scale items 27-40, which assess conduct disorder symptoms. One of these two subjects did not complete the study. The other showed improvement in their conduct disorder symptoms based on Vanderbilt items 27-40, which decreased from 16 to 12 between weeks 1 and 5.

Example 4. Treatment with Fasoracetam Monohydrate (NFC-1) of ADHD Patients with CNVs in mGluR Network Genes and Impact on Obsessive Compulsive Symptoms

Among the 30 ADHD subjects tested in the open-label Phase Ib clinical trial described in Example 3, eight had symptoms of obsessive compulsive-disorder (OCD). One of the subjects with tics also had symptoms of OCD. In all eight subjects, OCD symptoms improved during therapy with NFC-1.

One subject with OCD also had a history of ear scratching (i.e dermatillomania), leading to a bleeding ulcer. The bleeding ulcer healed during therapy with NFC-1, indicating that the subject's dermatillomania symptoms had reduced during NFC-1 therapy.

Example 5. Study of Phenotypes Associated with mGluR Network CNVs

A total of 1,000 ADHD patients aged 6-17 years were enrolled in a trial to consider phenotypes that may be associated with CNVs in Tier 1 or 2 mGluR network genes. Study sites collected saliva for a DNA sample. Each DNA sample was then subjected to DNA extraction, genetic sequencing, and biobanking of DNA.

Genetic sequencing results together with medical history were used to evaluate genotype (based on genetic sequencing) and phenotype (based on interviews conducted by a clinician with the subject's parent(s)/guardian(s)). Subjects had ADHD as defined by the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-V).

A single clinician posed a series of questions related to potential behavioral or health phenotypes to the parent(s) or legal guardian(s) of the subjects. For each individual phenotype, the parent/guardian was asked: “Is this a current concern” and a Yes or No answer was collected. The clinician determined the frequency of Yes and No responses to generate phenotype data.

The study found that prevalence of anger control as a current concern for parents was 58.9% in ADHD subjects with a Tier 1 or 2 mGluR network gene CNV but only 47.4% in ADHD subjects without such an mGluR network gene CNV. This difference was statistically significant (odds ratio of 1.59, P=0.003). This odds ratio of greater than 1 implies a higher prevalence of current anger control concerns in parents in ADHD subjects who had a Tier 1 or 2 mGluR network gene CNV versus those without such a CNV.

The prevalence of disruptive behavior as a current concern for parents was 57.1% in ADHD subjects with a Tier 1 or 2 mGluR network gene CNV and 43.9% in ADHD subjects without such an mGluR network gene CNV. This difference was also statistically significant (odds ratio of 1.70, P<0.001), indicating a higher prevalence of current disruptive behavior concerns in parents in ADHD subjects who also had an mGluR network gene mutation versus those without a mutation.

Example 6 Copy Number Variation in mGluR Network Genes in ADHD Subjects with Co-Morbid Disorders

Samples from 2707 known ADHD pediatric subjects (mean age of about 10-10.5 years) were genotyped on 550/610 Illumina chips to determine if they have one or more CNVs in Tier 1 or Tier 2 genes. The 2707 subjects included 759 females and 1778 males of African American or white ethnicity (1063 and 1483, respectively). 430 of the 2707 subjects (16.9%) had at least one CNV in an mGluR Tier 1 or Tier 2 gene.

The 2707 subjects' records were also checked to determine if they had co-morbid diagnoses according to the World Health Organization International Classification of Diseases 9th Edition (ICD-9). Of the 2707 subjects, 1902 (about 70%) had comorbidities while 805 did not. Of those 1902 subjects with comorbidities, about 30% had more than one comorbidity, and about 20% had two or more, while smaller percentages had larger numbers of comorbidities.

The most prevalent comorbidities, each occurring in more than 100 of the subjects, are listed in Table 4. The table lists the comorbidities by ICD-9 code and provides the number of cases among the 2707 subjects (column titled “N”) and name for each co-morbid condition or disorder.

TABLE 4 ICD-9 Code N Name N_299.00 342 Autistic disorder, current or active state N_299.80 267 Other specified pervasive developmental disorders, current or active state N_299.90 179 Unspecified pervasive developmental disorder, current or active state N_300.00 407 Anxiety state unspecified N_311 244 Depressive disorder not elsewhere classified N_312.9 568 Unspecified disturbance of conduct N_313.81 313 Oppositional defiant disorder (ODD) N_314.9 120 Unspecified hyperkinetic syndrome of childhood N_315.2 320 Other specific developmental learning difficulties N_315.31 189 Expressive language disorder N_315.32 157 Mixed receptive-expressive language disorder N_315.39 327 Other developmental speech disorder N_315.4 116 Developmental coordination disorder N_315.5 160 Mixed development disorder N_315.8 398 Other specified delays in development N_315.9 479 Unspecified delay in development N_319 110 Unspecified intellectual disabilities

The comorbidies in Table 4 tend to cluster into a few different groups: disorders related to anxiety, depression, or mood; prevalent developmental disorders; less prevalent developmental disorders; and autism and related disorders.

The genotype data and the comorbidity data were then combined to determine how many of the subjects with CNVs in Tier 1 or 2 mGluR network genes also had comorbidities. It was found that 316 of the subjects with such a CNV also had at least one comorbidity (about 18% of the CNV-positive subjects or about 12% of the total subjects) while 114 of the subjects without a Tier 1 or 2 mGluR network gene CNV had at least one comorbidity (about 15% of the CNV-negative subjects or about 4% of the total subjects). This difference showed a P value of 0.118. Thus, comorbidities tended to be more common in CNV-positive than in CNV-negative subjects overall. When only subjects identifying as white ethnicity are considered, there was a highly significant correlation between mGluR CNVs and ADHD comorbidities. Specifically, 218 of 1483 subjects had at least one CNV in a Tier 1 or 2 mGluR network gene, and, of those 218 subjects, 169 also had a comorbidity whereas 49 did not. That difference showed a P value of 0.004. 

What is claimed is:
 1. A method for diagnosing and treating conduct disorder in a subject comprising: (a) isolating a sample comprising nucleic acid from a subject, (b) detecting at least one copy number variation (CNV) in a mGluR network gene of the subject, (c) administering an effective amount of fasoracetam to the subject with at least one CNV in at least one mGluR network gene; and (d) assessing said subject for a reduction in anti-social symptoms associated with conduct disorder.
 2. The method of claim 1, wherein the CNV is a deletion or a duplication and said subject has a score of 2 or 3 on at least two of the 14 Vanderbilt scale items 27-40.
 3. The method of claim 1, wherein fasoracetam is fasoracetam monohydrate.
 4. The method of claim 1, wherein the subject has a CNV in at least 2 mGluR network genes.
 5. The method of claim 1, wherein said detecting at least one CNV in a mGluR network gene comprises subjecting the sample to a screen that assesses CNVs in at least 5 Tier 1 mGluR network genes.
 6. The method of claim 1, wherein detecting at least one CNV in a mGluR network gene comprises subjecting the sample to a screen that assesses CNVs in at least 50 Tier 2 mGluR network genes.
 7. The method of claim 1, wherein the subject is a pediatric or adolescent subject.
 8. The method of claim 7, wherein the pediatric patient is between the ages of 12 and
 18. 9. The method of claim 1, wherein the subject has antisocial personality disorder.
 10. The method of claim 1, wherein the subject has at least one CNV in a Tier 1 mGluR network gene.
 11. The method of claim 1, wherein the subject has at least one CNV in a Tier 2 mGluR network gene.
 12. The method of claim 1, wherein the subject has at least one CNV in a Tier 1 or Tier 2 mGluR network gene but does not have a CNV in a Tier 3 mGluR network gene.
 13. The method of claim 1, wherein fasoracetam is administered at a dose of 100-400 mg twice daily.
 14. The method of claim 1, wherein fasoracetam is administered at a dose of 200-400 mg twice daily. 